11/04/2026
Dr James Bolt, a consultant specialising in movement disorders at Cwm Taf Morgannwg UHB, has become the first doctor in Wales to offer Produodopa a medication to help treat patients with advanced Parkinson’s disease.
Parkinson’s is a progressive neurological disease, which involves a decline in dopamine levels. Dopamine is produced mainly in the brain and it helps with movement, memory, mood and control of organ functions like the gut.
Patients with Parkinson’s disease have lower levels of Dopamine and present with symptoms including tremor, shuffling gait, stiffness of limbs, and mask like facial expression. However, they may have had many other features of the disease before they present with these symptoms (such sleep disturbances or problems with their bowels).
Traditionally, Parkinson’s disease has been treated with oral dopamine. However, the dose has to be increased as their body produces less dopamine. Large doses of dopamine given orally can cause issues with other movements (called dyskinesias) which can be difficult for the patient.
Produodopa is a medication for advanced Parkinson’s Disease that is administered via a needle under the skin using a special pump. The pump delivers a small amount of the medication each hour which is gradually absorbed into the bloodstream. The pump is easy to programme and to use. It works 24 hours a day, meaning that the patient has a more consistent level of dopamine in their body throughout both the day and night.
Produodopa simplifies treatment for patients with advanced Parkinsons disease. It helps not only their motor symptoms (tremor, slowness, stiffness and dyskinesias), but has also been effective in improving their non-motor symptoms (sleep; bowel function, mood etc.). Overall. It has been shown in initial trials to improve the patients’ quality of life.