29/12/2025
وَ في أنفُسِكُم مع 💜 الباحث السريري الإبتكاري الرئيس 💜
■ Highlights
• , , , , and study of the oldest human
• Despite molecular hallmarks of , absence of major age-associated diseases
• Resilient genetic variants and low-inflammation metabolic profile reduce aging risks
• Bacteria occurrence and epigenome profile resembling younger individuals
■ Summary
▪︎ , exemplified by , presents a paradox in understanding aging:
despite advanced age, they maintain relatively good health.
▪︎ To investigate this duality, we have performed a high-throughput study of the world’s oldest living person, interrogating her , , , , , and epigenome, comparing the results with larger matched cohorts.
▪︎ The emerging picture highlights different pathways attributed to each process:
the record-breaking advanced age is manifested by telomere attrition, abnormal B cell population, and clonal hematopoiesis, whereas absence of typical is associated with rare European-population genetic variants, low inflammation levels, a rejuvenated bacteriome, and a younger epigenome.
▪︎ These findings provide a fresh look at , suggesting biomarkers for , and potential strategies to increase life expectancy.
▪︎ The extrapolation of our results to the general population will require larger cohorts and longitudinal prospective studies to design potential anti-aging interventions.
In brief, Santos-Pujol and colleagues characterize the multiomics landscape of the human with the most extreme longevity. The study enables the association of advantageous genetic variants, an engaged lipid metabolism, low inflammation levels, a proficient immune system, a rejuvenated microbiome com...
