Oroboros Instruments

Oroboros Instruments Oroboros Instruments distributes the gold standard for O2k-technology High-Resolution Respirometry. We are a scientifically oriented organization.

Season’s greetings from all of us at Oroboros Instruments.Thank you to our customers, partners, and the global research ...
23/12/2025

Season’s greetings from all of us at Oroboros Instruments.
Thank you to our customers, partners, and the global research community for your trust and collaboration throughout the year.
We wish you a restful holiday season and a strong start into the new year.

Oroboros tip: Measure the instrumental background at the same temperature you use for your experiments. Temperature chan...
22/12/2025

Oroboros tip: Measure the instrumental background at the same temperature you use for your experiments. Temperature changes both POS-related O₂ consumption and back diffusion, which directly shifts the background O₂ flux and can bias corrections if the background was recorded under different conditions.

During photosynthesis measurements in microalgae, sufficient supplementation with NaHCO₃ is essential to ensure that O2 ...
17/12/2025

During photosynthesis measurements in microalgae, sufficient supplementation with NaHCO₃ is essential to ensure that O2 flux rates are not constrained by inorganic carbon availability. Adding bicarbonate directly to the Oroboros chamber helps to maintain inorganic carbon availability throughout the experiment.

Collection of the buffy coat is a critical step in the PBMC isolation workflow, as this layer contains the target mononu...
16/12/2025

Collection of the buffy coat is a critical step in the PBMC isolation workflow, as this layer contains the target mononuclear cells. Careful aspiration, avoiding contamination with erythrocytes, granulocytes or debris, helps maintain sample purity and improves the quality and reproducibility of downstream respirometric measurements with the O2k / NextGen-O2k.

How do chemo- and radiotherapy affect mitochondrial function in circulating immune cells?In a recent study using high-re...
11/12/2025

How do chemo- and radiotherapy affect mitochondrial function in circulating immune cells?

In a recent study using high-resolution respirometry with the Oroboros O2k, peripheral blood mononuclear cells (PBMCs) from breast cancer patients showed a transient increase in mitochondrial O₂ flux in both intact and permeabilized cells after chemo- and radiotherapy.

Learn more: https://buff.ly/cTA8JG9

Working with limited or low-respiration samples such as PBMCs?The Oroboros small-volume module (sV-Module) enables high-...
10/12/2025

Working with limited or low-respiration samples such as PBMCs?

The Oroboros small-volume module (sV-Module) enables high-resolution respirometry with minimal amounts of biological material, helping you obtain reliable data even when sample quantity is restricted.

Muceniece et al explored the potential of nettle leaf extract on hepatoprotection. High-resolution respirometry in HepG2...
08/12/2025

Muceniece et al explored the potential of nettle leaf extract on hepatoprotection. High-resolution respirometry in HepG2 cells showed that nettle leaf water extract significantly increased FN OXPHOS-linked O₂ consumption compared to control.

Learn more: https://buff.ly/xtydmMi

🟦 Are you using sticky tissues on your experiments? Make sure to clean your stirrers as part of your regular cleaning wo...
04/12/2025

🟦 Are you using sticky tissues on your experiments? Make sure to clean your stirrers as part of your regular cleaning workflow.

Following the DatLab protocols “Cleaning after use_stirrers” or “Cleaning_AfterUse_inhibitors”, simply stop the stirrer after the pre-wash, siphon the water from the chamber, remove the stirrer, wipe it thoroughly with a paper towel, rinse with clean water, and return it to the same chamber.
Consistent cleaning helps ensure high-quality, reproducible results in your experiments.

We are delighted to welcome Ana as our new Chloro Climber. As part of our Bioenergetics Adventurers, she will contribute...
03/12/2025

We are delighted to welcome Ana as our new Chloro Climber. As part of our Bioenergetics Adventurers, she will contribute to advancing our R&D activities and deepening our understanding of cellular bioenergetics and photobiology for our scientific community and customers worldwide.

In the F-pathway control state, fatty acid oxidation depends not only on electron transfer through the F-junction where ...
02/12/2025

In the F-pathway control state, fatty acid oxidation depends not only on electron transfer through the F-junction where electrons derived from fatty acids are transferred to electron-transferring flavoprotein dehydrogenase Complex (CETFDH) and subsequently pass through the Q-junction to Complex III (CIII) - but also on the concurrent generation of NADH.

Consequently, F-pathway respiration is influenced by both F-junction electron transfer and N-junction throughput, highlighting the importance of selecting a protocol that accounts for both contributions.

How do oxygen levels and the choice of respiration medium influence our mitochondrial readouts? Doerrier et al. (2024, F...
27/11/2025

How do oxygen levels and the choice of respiration medium influence our mitochondrial readouts?

Doerrier et al. (2024, Free Radic Biol Med) show that high O₂ regimes (~250–400 µM) can markedly increase measured O₂ flux, and that these effects depend strongly on the respiration medium.

learn more: https://buff.ly/fOYOCyo

Air and zero calibration are essential quality control procedures. They not only ensure the proper functioning of the se...
24/11/2025

Air and zero calibration are essential quality control procedures. They not only ensure the proper functioning of the sensor, but also that the measured signal (in µA) is correctly converted into an O2 concentration (in µM) as a function of barometric pressure, experimental temperature and solubility factor of the medium. Inaccurate calibration will directly result in incorrect O₂ concentration values.

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Schoepfstrasse 18
Innsbruck
6020

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Dienstag 09:00 - 12:00
13:00 - 16:00
Mittwoch 09:00 - 12:00
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Freitag 09:00 - 17:00

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