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Montag 09:00 - 16:00 Dienstag 09:00 - 12:00 13:00 - 16:00 Mittwoch 09:00 - 12:00 13:00 - 16:00 Donnerstag 09:00 - 12:00 13:00 - 16:00 Freitag 09:00 - 17:00

Oroboros Instruments

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Oroboros Instruments

Oroboros Instruments distributes the gold standard for O2k-technology High-Resolution Respirometry. We are a scientifically oriented organization.

15/01/2026

How to normalize when comparing mitochondrial function across samples that might differ in their mitochondrial content:

Scaling oxygen flux to a mitochondrial marker such as citrate synthase (CS) activity accounts for differences in mitochondrial density, and the marker specific oxygen flux (JO₂/CS) reflects mitochondrial quality rather than quantity.

14/01/2026

Hidden pitfall in Amplex UltraRed assays:

In tissues like liver, kidney, intestine, or stomach, mitochondrial carboxylesterases can oxidize AmR without H₂O₂ (and without HRP), generating a misleading fluorescence slope.

Adding PMSF to the assay medium helps shut down this artefact and keeps H₂O₂ flux interpretation on track.

12/01/2026

Publication spotlight: GRACILE syndrome is a severe mitochondrial disorder caused by mutations leading to Complex III deficiency.

In a GRACILE model, mitochondrial H₂O₂ production was elevated in kidney and heart and was reduced by alternative oxidase AOX expression. While increased H₂O₂ was excluded as an early pathogenesis mechanism, the data support the idea that ROS can still shape late -stage disease trajectories.

Rajendran et al., EMBO Mol Med (2019). DOI: 10.15252/emmm.201809456

05/01/2026

Because H₂O₂ production by the sample is typically low, background fluorescence slopes in Amplex Red/UltraRed assays can markedly distort flux measurements. Adding the iron chelator DTPA to the assay medium suppresses iron-mediated side reactions and reduces unintended UltroxRed formation, lowering the background fluorescence slope.

23/12/2025

Season’s greetings from all of us at Oroboros Instruments.
Thank you to our customers, partners, and the global research community for your trust and collaboration throughout the year.
We wish you a restful holiday season and a strong start into the new year.

22/12/2025

Oroboros tip: Measure the instrumental background at the same temperature you use for your experiments. Temperature changes both POS-related O₂ consumption and back diffusion, which directly shifts the background O₂ flux and can bias corrections if the background was recorded under different conditions.

17/12/2025

During photosynthesis measurements in microalgae, sufficient supplementation with NaHCO₃ is essential to ensure that O2 flux rates are not constrained by inorganic carbon availability. Adding bicarbonate directly to the Oroboros chamber helps to maintain inorganic carbon availability throughout the experiment.

16/12/2025

Collection of the buffy coat is a critical step in the PBMC isolation workflow, as this layer contains the target mononuclear cells. Careful aspiration, avoiding contamination with erythrocytes, granulocytes or debris, helps maintain sample purity and improves the quality and reproducibility of downstream respirometric measurements with the O2k / NextGen-O2k.

11/12/2025

How do chemo- and radiotherapy affect mitochondrial function in circulating immune cells?

In a recent study using high-resolution respirometry with the Oroboros O2k, peripheral blood mononuclear cells (PBMCs) from breast cancer patients showed a transient increase in mitochondrial O₂ flux in both intact and permeabilized cells after chemo- and radiotherapy.

Learn more: https://buff.ly/cTA8JG9

10/12/2025

Working with limited or low-respiration samples such as PBMCs?

The Oroboros small-volume module (sV-Module) enables high-resolution respirometry with minimal amounts of biological material, helping you obtain reliable data even when sample quantity is restricted.

08/12/2025

Muceniece et al explored the potential of nettle leaf extract on hepatoprotection. High-resolution respirometry in HepG2 cells showed that nettle leaf water extract significantly increased FN OXPHOS-linked O₂ consumption compared to control.

Learn more: https://buff.ly/xtydmMi

04/12/2025

🟦 Are you using sticky tissues on your experiments? Make sure to clean your stirrers as part of your regular cleaning workflow.

Following the DatLab protocols “Cleaning after use_stirrers” or “Cleaning_AfterUse_inhibitors”, simply stop the stirrer after the pre-wash, siphon the water from the chamber, remove the stirrer, wipe it thoroughly with a paper towel, rinse with clean water, and return it to the same chamber.
Consistent cleaning helps ensure high-quality, reproducible results in your experiments.

Adresse

Schoepfstrasse 18
Innsbruck
6020

Öffnungszeiten

Montag	09:00 - 16:00
Dienstag	09:00 - 12:00
	13:00 - 16:00
Mittwoch	09:00 - 12:00
	13:00 - 16:00
Donnerstag	09:00 - 12:00
	13:00 - 16:00
Freitag	09:00 - 17:00

Telefon

0043512566796

Webseite

http://www.oroboros.at/

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