Oroboros Instruments

Oroboros Instruments Oroboros Instruments distributes the gold standard for O2k-technology High-Resolution Respirometry. We are a scientifically oriented organization.

Meet Jack, our new Graphic design & IT Chimera at Oroboros!He joins us to design and shape our media, enhance our digita...
26/02/2026

Meet Jack, our new Graphic design & IT Chimera at Oroboros!
He joins us to design and shape our media, enhance our digital presence, and support IT and AI-based workflows.

We are pleased to welcome Martina as our new Lab Potioneer!She will support our experiments and preparation of chemicals...
23/02/2026

We are pleased to welcome Martina as our new Lab Potioneer!
She will support our experiments and preparation of chemicals, and be a key part of our research activities.

The bactericidal antibiotic streptomycin does more than kill bacteria. In human cancer cells, it inhibits mitochondrial ...
19/02/2026

The bactericidal antibiotic streptomycin does more than kill bacteria. In human cancer cells, it inhibits mitochondrial Complex IV, boosts ROS production, and increases both routine and leak respiration, pointing to enhanced proton leak at the inner mitochondrial membrane.

Why doesn’t pyruvate, malate and glutamate (N-pathway), or succinate (S-pathway) supported respiration indicate the acti...
18/02/2026

Why doesn’t pyruvate, malate and glutamate (N-pathway), or succinate (S-pathway) supported respiration indicate the activity of Complex I or II on their own? These substrate-supported respiration rates depend on multiple mitochondrial components both upstream and downstream of CI and CII, reflecting integrated pathway control rather than single-enzyme activity.

Glioblastoma paper spotlight: tumor-derived cells show elevated DHODH-linked respiration versus parental cells, supporti...
12/02/2026

Glioblastoma paper spotlight: tumor-derived cells show elevated DHODH-linked respiration versus parental cells, supporting an important role for DHODH and functional mitochondrial respiration in driving brain tumor growth.

A recurring issue with real conceptual consequences: Complex II does not oxidize “FADH₂” as a substrate. The substrate ...
11/02/2026

A recurring issue with real conceptual consequences: Complex II does not oxidize “FADH₂” as a substrate. The substrate is succinate. Better representation of fundamental concepts improves mechanistic accuracy and prevents downstream misinterpretation of SUIT steps and pathway diagrams.

New to high-resolution respirometry or exploring new tools for mitochondrial research?Join our introductory talk on the ...
10/02/2026

New to high-resolution respirometry or exploring new tools for mitochondrial research?

Join our introductory talk on the Oroboros NextGen-O2k — functions, applications & research use cases.

📅 Feb 17 | 14:00–15:00 GMT+1
🔗 Teams: https://buff.ly/pp47Sau

The Q-junction is the convergence point for multiplepathway inputs. F-, N-, S-, Dho- and Gp-pathways all feed into the Q...
09/02/2026

The Q-junction is the convergence point for multiplepathway inputs. F-, N-, S-, Dho- and Gp-pathways all feed into the Q-junction and can be assessed individually or in combination using different substrates. Clear pathway language helps with clean interpretation and communication.

New publication highlight: mtG3PDH inhibition in androgen receptor-negative prostate cancer cells shows a strong depende...
05/02/2026

New publication highlight: mtG3PDH inhibition in androgen receptor-negative prostate cancer cells shows a strong dependence on extracellular pyruvate concentrations, affecting routine respiration and H₂O₂ production. A good reminder that the same enzyme inhibition can look different depending on substrate context and assay design.

The Gp-pathway is often underused in pathway-resolved bioenergetics. mtG3PDH oxidizes glycerophosphate and feeds electro...
03/02/2026

The Gp-pathway is often underused in pathway-resolved bioenergetics. mtG3PDH oxidizes glycerophosphate and feeds electrons into the Q-junction, and SUIT protocols can quantify this contribution directly. If you care about ET-pathway partitioning, it’s a powerful handle.

Pyruvate isn’t always a “neutral” background substrate. If you use pyruvate in the protocol, keep in mind it can competi...
02/02/2026

Pyruvate isn’t always a “neutral” background substrate. If you use pyruvate in the protocol, keep in mind it can competitively reverse cyanide inhibition of CIV, making CIV inhibition less reliable. For robust CIV blockages, azide may be the better choice under pyruvate-containing conditions.

Small handling detail, big impact on O₂ control.When adding permeabilized fibers to the Oroboros chamber, pause stirrin...
29/01/2026

Small handling detail, big impact on O₂ control.
When adding permeabilized fibers to the Oroboros chamber, pause stirring while the chamber is open and restart only when it’s nearly closed. This helps minimize changes in O₂ concentration during sample addition and keeps you closer to your intended O₂ setpoint.

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Schoepfstrasse 18
Innsbruck
6020

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Montag 09:00 - 16:00
Dienstag 09:00 - 12:00
13:00 - 16:00
Mittwoch 09:00 - 12:00
13:00 - 16:00
Donnerstag 09:00 - 12:00
13:00 - 16:00
Freitag 09:00 - 17:00

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0043512566796

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