Nugenis

NUGENIS hat den EBP-Epigenetic Brain Protector® entwickelt und für den Schutz der Gehirnzellen ein

NUGENIS ist ein junges Startup, das unter anderem mit dem innovativen EBP® - Epigenetic Brain Protector auf dem österreichischen Markt vertreten ist. Unsere Kernkompetenzen liegen in unserer Partizipation an internationalen Forschungsgruppen, unserer jahrelangen Erfahrung im Bereich der Angewandten Epigenetik. Unser erstes Produkt ist zugleich Goldmedaillen-Gewinner (2015) auf der international renommiertesten Innovations- und Erfindermesse, der iENA in Nürnberg für herausragende Leistungen im Bereich des Schutzes gegen Neurodegeneration. NUGENIS steht für Innovation, wissenschaftliches KnowHow und kurze Wege von der Forschung zum fertigen Produkt. Auf www.nugenis.eu finden sich nähere Informationen zur Forschung im Bereich der Angewandten Epigenetik.

04/11/2025

Introduction: The Fractured Symphony of Life

Health is the art of coherence — the ongoing dialogue between Ich-Welt, Wir-Welt, and Umwelt.
When one of these dimensions falls out of tune, the others soon follow.
The collapse of individual resilience mirrors the erosion of social trust and the degradation of the biosphere.
In molecular terms, it is one process: the loss of rhythmic balance in the network of life.

The three enemies of life — self-conflict, social dissonance, and ecological chaos — are not independent.
They are the same melody played in different octaves: psychological, social, planetary.

- The Self: Molecular Disintegration through Inner Conflict

When inner dialogue becomes self-attack, stress hormones replace serenity.
Cortisol, MAO-B, and oxidative radicals act as chemical agents of alienation.
The epigenome, once fluid and adaptive, hardens into a defensive script.
Genes of trust and creativity fall silent; those of vigilance and inflammation awaken.

Introduction: The Fractured Symphony of Life Health is the art of coherence — the ongoing dialogue between Ich-Welt, Wir-Welt, and Umwelt. When one of the

28/10/2025

The placebo effect has long been treated as an illusion—something that “tricks” the mind into healing itself. Yet modern science reveals a deeper truth: the placebo is not deception; it is a conscious invitation to the body’s own intelligence. Even when patients are told that they are taking an open placebo—a capsule with no active ingredient—their pain can diminish. Awareness does not weaken the effect; it refines it.

In a Harvard study on chronic back pain, participants knowingly took inert pills labeled “Placebo.” Still, they reported significant relief and improved mood. Functional brain imaging showed activation of the prefrontal cortex, the anterior cingulate cortex, and the periaqueductal gray—the same neural pathways engaged by genuine opioid analgesics. Something profoundly biological was happening—without chemistry, without deception.

Expectation is not just a psychological event; it is a biological one.

The placebo effect has long been treated as an illusion—something that “tricks” the mind into healing itself. Yet modern science reveals a deeper truth: t

24/10/2025

The Interface of Life
Every cell lives at the boundary between self and world. Its membrane defines identity, yet survival depends on a continuous dialogue across that boundary. Through channels and transporters, the cell negotiates with its environment — receiving nutrients, exchanging signals, releasing neurotransmitters. These gates are not fixed. Their permeability is dynamically regulated by epigenetic mechanisms that adapt the rhythm of exchange to stress, nutrition, and emotional state. In this sense, membrane transporters are the executive tools of the epigenome — where molecular memory becomes cellular behavior.

Serotonin Transport and Emotional Regulation
The SLC6A4 gene encodes the serotonin transporter (SERT), responsible for clearing serotonin from the synaptic cleft. Its promoter methylation is one of the best-established epigenetic marks in psychiatric research.

The Interface of Life Every cell lives at the boundary between self and world. Its membrane defines identity, yet survival depends on a continuous dialogue acr

17/10/2025

Lessons from Twins
Twins are nature’s mirror—a living experiment in sameness and divergence. Identical twins begin as one fertilized egg, one shared genome, one biological text duplicated in perfect sequence. Yet as life unfolds, the two copies drift apart. Their laughter may echo the same rhythm, but their biology begins to hum in different keys. What starts as genetic identity becomes an epigenetic conversation: two versions of the same story, annotated by experience.
Epigenetic Divergence: From One Genome to Two Lives
From the perspective of epigenetics, twins embody the dialogue between the Ich-world, the We-world, and the Umwelt. The Ich-world—the inner realm of perception and feeling—interprets the shared environment differently in each twin. The We-world—the relational field of family, peers, and culture—feeds each sibling with distinct emotional and social nutrients.
#•DNAmethylation

Lessons from Twins Twins are nature’s mirror—a living experiment in sameness and divergence. Identical twins begin as one fertilized egg, one shared genome

13/10/2025

For decades, biology was guided by a powerful metaphor: DNA as the “book of life.” The double helix seemed to contain every instruction for the formation of a living being. Yet as scientists began decoding the human genome, a surprising realization emerged—genes alone could not explain the complexity of life, behavior, or disease. The genome provides the letters, but life writes the story.

The Limits of Genetic Determinism
Early genetic models assumed a one-to-one relationship between genes and traits. But the Human Genome Project shattered that illusion: humans possess only about 20,000 protein-coding genes—barely more than a roundworm. If DNA were destiny, we would expect a far simpler creature. The missing information lies not in the sequence itself but in how it is read. Identical twins, born with the same DNA, can differ profoundly in health, personality, and lifespan. Their divergence arises from molecular marks that regulate gene expression without altering the code.
#•DNAmethylation

For decades, biology was guided by a powerful metaphor: DNA as the “book of life.” The double helix seemed to contain every instruction for the formation of

07/10/2025

Bones and Muscles as Epigenetic Witnesses

The musculoskeletal system is often seen as a structural scaffold, but it is in fact a living archive of activity, nutrition, and age. Bones and muscles register the stresses of daily life, the nutrients we consume, and the resilience or fragility shaped by epigenetic programming.

Epigenetics of Muscle Development and Plasticity

Skeletal muscle is characterized by extraordinary adaptability. Myogenesis is directed by transcription factors such as MyoD and Myf5, whose activity is epigenetically regulated by histone modifications. Satellite cells, the muscle’s resident stem cells, depend on DNA methylation and microRNAs for activation and regeneration. Physical training induces histone acetylation in genes governing oxidative metabolism, while inactivity leads to repressive marks and atrophy.

Bones and Muscles as Epigenetic Witnesses The musculoskeletal system is often seen as a structural scaffold, but it is in fact a living archive of activity,

03/10/2025

Introduction: A Small Molecule with Vast Influence
S-adenosylmethionine (SAM-e) is a small molecule with vast biological reach. As the universal methyl donor, it influences DNA, RNA, histones, neurotransmitters, and membranes. This positions SAM-e at the intersection of metabolism, epigenetics, and clinical medicine.
Biochemistry and Epigenetics
SAM-e is synthesized in the liver from methionine and ATP. It donates methyl groups for multiple processes:
- DNA methyltransferases (DNMTs): regulating gene silencing and activation.
- Histone methylation: shaping chromatin structure and transcription.
- Neurotransmitter metabolism: supporting serotonin, dopamine, and norepinephrine pathways.
After methyl transfer, SAM-e is converted to S-adenosylhomocysteine (SAH), which is then metabolized to homocysteine, requiring folate, vitamin B12, and B6 for recycling.
#•SAMeAlzheimer #•SAMeantidepressant #•SAMebenefits #•SAMedepression #•SAMeepigenetics #•SAMejoints #•SAMeliver #•SAMemethylation #•SAMequality #•SAMesideeffects

Introduction: A Small Molecule with Vast Influence S-adenosylmethionine (SAM-e) is a small molecule with vast biological reach. As the universal methyl donor,

27/09/2025

Red ThreadBalance is the essence of life. The endocannabinoid system (ECS) is a master regulator of stress, mood, pain, and immunity — and epigenetics decides how sensitive or resilient this system becomes.

Case VignetteA young man suffers from chronic anxiety and inflammatory bowel disease. His genetic tests show nothing remarkable, but his history tells the story: childhood trauma, poor diet, long-term stress. These experiences did not alter his DNA, but they left epigenetic scars on his endocannabinoid receptors and enzymes. His ECS now overreacts to stress signals and underperforms in inflammation control. With targeted nutrition, stress reduction, and phytocannabinoids, part of this epigenetic imbalance can be rewritten.

Main Text

1. The Architecture of the Endocannabinoid System

Endocannabinoids: Anandamide (AEA) and 2-AG, produced on demand.

Receptors: CB1 (brain, nervous system), CB2 (immune system, periphery).

Red ThreadBalance is the essence of life. The endocannabinoid system (ECS) is a master regulator of stress, mood, pain, and immunity — and epigenetics decides

20/09/2025

Red Thread

The human soul, as Erich Fromm saw it, is not a metaphysical mystery but the dialectical essence of being: love and fear, freedom and dependence, creation and destruction. Epigenetics reveals how these opposing forces leave molecular traces. The dialectic of the soul and the biology of gene expression mirror each other.

Essay

Philosophers once spoke of the soul as immaterial, beyond biology. Erich Fromm broke with this. For him, the soul was dialectical: a space of contradictions that defines human existence. The tension between love and aggression, freedom and conformity, joy and despair — these were not errors to be eliminated but the very conditions of being human.

Epigenetics adds a new lens. What Fromm described in psychological and ethical terms can be seen in biology as epigenetic inscriptions of lived experience. The soul’s contradictions are mirrored by the genome’s plasticity.

Red Thread The human soul, as Erich Fromm saw it, is not a metaphysical mystery but the dialectical essence of being: love and fear, freedom and de

14/09/2025

The Brain’s Epigenetic Story
Guiding Question
How does the brain store experiences as epigenetic marks—shaping memory, emotion, and vulnerability to disease?
The Red Thread
The brain is both hardware and storybook. Neurons do not change their DNA, but their epigenetic landscape is constantly rewritten by learning, stress, trauma, love, and creativity. This molecular plasticity explains resilience, mental illness, and neurodegeneration.

- Memory is written in synapses.
- Experience engraves marks in chromatin.

Case Vignette — “Trauma and Renewal”
Sophie, 29, survived early childhood neglect. As an adult, she struggles with anxiety but also shows remarkable resilience after therapy and mindfulness practice.

Under the hood:

- Early trauma → hypermethylation of NR3C1 (stress receptor).
- Reduced BDNF acetylation → impaired neuroplasticity.
- Therapy + meditation → gradual restoration of BDNF and stress gene balance.

The Brain’s Epigenetic Story Guiding Question How does the brain store experiences as epigenetic marks—shaping memory, emotion, and vulnerability to disea

10/09/2025

The Heart’s Epigenetic Story
Guiding Question
How does the heart remember love, stress, and lifestyle through its epigenome?
The Red Thread
The heart is not only a pump—it is a memory organ. Nutrition, stress, toxins, and emotions engrave marks on cardiac genes, shaping rhythm, resilience, and risk. Epigenetics explains why one heart thrives and another fails, even with the same genetic script.

- The heart listens to life’s music.
- Epigenetics records its rhythm.

Case Vignette — “Two Heartbeats”
Thomas, 55, and Michael, 55, are cousins. Both carry similar genetic risk for coronary disease. Thomas lives with chronic stress, little exercise, and high-fat diet. Michael practices endurance sports, eats Mediterranean, and manages stress.

Under the hood:

- Thomas: inflammatory gene hypomethylation, endothelial dysfunction.
- Michael: protective acetylation of antioxidant and repair genes.
- Same risk alleles → diverging epigenetic pathways.

The Heart’s Epigenetic Story Guiding Question How does the heart remember love, stress, and lifestyle through its epigenome? The Red Thread The heart is n

08/09/2025

Epigenetics: The Language of Genes
Guiding Question
If DNA is the alphabet, what grammar lets cells turn the same letters into different meanings—health or disease, repair or inflammation?
The Red Thread
Genes don't act alone; context writes meaning.

Signals (food, light, stress, touch) are converted into metabolic currencies (SAM, acetyl-CoA, NAD⁺, α-KG) that pay the enzymes which write, erase, and read chromatin marks.

The result is a grammar of when, where, and how much genes speak—dynamic, reversible, and trainable.

Case Vignette — "Same Letters, Different Story"
Two sisters, Ava and Lila, carry the same high-risk allele for Type 2 diabetes.

Ava works nights, eats late, sleeps short. Her circadian genes (CLOCK/PER) drift, hepatic enhancers open at gluconeogenic loci, and promoter methylation at insulin-signaling genes wobbles. Fasting glucose creeps up.

Lila keeps daylight hours, trains most mornings, and eats fiber-rich meals.
#•DNAmethylation ⁺

Epigenetics: The Language of Genes Guiding Question If DNA is the alphabet, what grammar lets cells turn the same letters into different meanings—health or

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