ENDIA

Australia's largest study into the cause of type 1 diabetes. Recruitment to the study is now complete. Find out more at www.endia.org.au and Harry B.

Recruitment to the ENDIA Study has closed. The ENDIA (Environmental Determinants of Islet Autoimmunity) study is looking into what contributes to the development of Type 1 Diabetes in early childhood. Type 1 Diabetes in children is twice as common as it was 20 years ago. This is because our environment has changed and at-risk children are more likely to develop Type 1 Diabetes. If we can understan

d exactly what in the environment is harmful or protective, we can develop strategies to prevent Type 1 Diabetes. We believe that children are exposed to these environmental triggers very early in life, perhaps even before they are born. Accordingly, the ENDIA study has recruited 1511 participants across Australia from the pregnancy or up to 6 months of age that have a first-degree relative (i.e. baby's Mum, Dad or older sibling) with Type 1 Diabetes. ENDIA is an observational investigation and does not involve any study medications or treatments. Further information is available on the ENDIA website at www.endia.org.au. This research has been supported by JDRF Australia, JDRF-I, Australian Research Council Special Research Initiative in Type 1 Juvenile Diabetes and the Leona M. Helmsley Charitable Trust. Please note, comments and opinions made by others are not necessarily endorsed by the ENDIA Study Team. All content posted by the ENDIA Team has had ethical approval for public view. Thanks for your interest in finding the causes of Type 1 Diabetes!

16/04/2026

Help inform a national screening and monitoring program!

Seeking ENDIA families with experience of screening and monitoring for coeliac antibodies to participate in online interviews.

If you or your child have had coeliac antibodies discovered through ENDIA Study screening and monitoring, Dr Mia would love to chat to you.

Interviews take around 30-45 minutes, are online, flexible/out of hours, with a Coles/Myer voucher for your time.

For a no obligation chat, email Dr Mia at mia.majstrovic@adelaide.edu.au or complete this interest form: https://adelaideuniwide.qualtrics.com/jfe/form/SV_ai1gunhvweaEHjg

Thank you!

13/04/2026

This is Ben. Ben is 10. Ben is from Western Australia.

Ben has completed all 10 years with ENDIA through the Regional Program and we are very VERY grateful to him and his family for all they contributed.

Bye Ben!

We recommend all our ENDIA graduates continue screening with Type1Screen. The risk of developing reduces with age. Although chances are low, it is possible to develop diabetes antibodies in the teenage years. For more information and to register, go to www.type1screen.org

10/04/2026

A huge thank you from Dr Aveni Haynes and the ENDIA CGM study team 💙

Late last year we wrapped up our CGM study — and the numbers speak for themselves: over 200 CGM sessions completed, many by families who came back again and again to contribute.

That is an extraordinary commitment.

Wearing a CGM, managing the logistics, fitting study visits around busy family lives — none of this is small. This helps us understand how blood glucose patterns in early life might connect to the development of type 1 diabetes in later life.

To every parent, caregiver, and child who took part — thank you. You are the reason this research exists. The data you've helped generate will take time to analyse fully, but its potential to improve how we understand and one day prevent T1D is real.

We are so grateful to have you as part of the ENDIA family. 🙏

Access Dr Haynes message of thanks here: https://vimeo.com/1180654329

06/04/2026

This is the amazing Dr Dao who manages all the samples collected from our very special ENDIA Families. Learn more about all the samples in our bio bank with thanks to Dao and Breakthrough T1D Australia.

We're getting excited about the possibilities children's deciduous teeth may bring in terms of helping answer the question "what causes type 1 diabetes?" Like rings of bark in a tree trunk, layers of tooth enamel can be analysed to determine exposures as far back as the first trimester of pregnancy!

Exciting analyses ahead which we hope Dr Dao will help lead as more children's teeth are collected. If your family is in ENDIA and you are yet to donate a tooth, please speak with your ENDIA coordinator or email us at endia@adelaide.edu.au

05/04/2026

Naelani is 10! I’ll say it again! Naelani is 10. Happy birthday my friend.

Thanks for all your information and samples to help us find the causes of .

You’re the best and we hope you had the best birthday too.

For information about continued screening and to register, go online to Type1Screen www.type1screen.org

Love from the

🌟⭐️💫

02/04/2026

🦠 Gut bacteria bile acids may influence type 1 diabetes development

Researchers analyzed data and samples from 303 children (ages 3-36 months) and found gut bacteria create special bile acid molecules. These differ in children who develop diabetes autoantibodies compared to those who do not.

Why it matters: These molecules influence immune cell balance. Identifying this could lead to:

• Earlier T1D identification
• Dietary or probiotic interventions
• Better understanding of gut-immune connection

Read more at 🔗 https://www.nature.com/articles/s41467-025-56484-8

30/03/2026

Wave the flag. Fletcher has finished ENDIA study visits.

Fletcher, and his two siblings, have been involved in ENDIA since the . What a significant contribution to finding what causes .

Well done Mum! Jess has gone the extra mile (quite literally driving across NSW) to ensure ENDIA had all the samples and information possible from her three .

A massive thanks to Fletcher and the Trezona family for all their time and efforts.

27/03/2026

Leo, look how you’ve grown! From a bub before birth to nearly 10 years old, you have participated in the ENDIA Study regional program. We’ve loved watching you become a big boy from afar.

What a treat it was for regional nurse, Sarah, to be able to say farewell in person at your final ENDIA visit in Adelaide.

Thank you, and your mum, for all your help with our into the causes of . You’ve been amazing.

For further antibody testing, we recommend Type1Screen. This program is free for any family member of those diagnosed with and less intensive than the . For information and registration go to www.type1screen.org

24/03/2026

🏅 Josiah's Final ENDIA Visit: Mission Complete!

Look at that smile! Josiah received his gold medal at his last ENDIA Study visit, and we think he's pretty proud of himself—and he should be! 💛

From his very first visit as a baby to today, Josiah has been a . Every visit, every sample, every moment of participation has contributed to groundbreaking prevention .

To Josiah: Thank you for being such an amazing research champion! That gold medal is well-deserved. 🌟

To Josiah's family: Your dedication over the years has been incredible. Thank you for making a priority and for helping pave the way toward prevention for future generations.

We're going to miss seeing you at study visits, Josiah! 💙
________________________________________

The ENDIA Study follows children from as early as the pregnancy to understand early-life factors influencing type 1 diabetes development. www.endia.org.au

21/03/2026

🔬 Antibiotics Before Pregnancy May Affect Baby's Chance of Diabetes

Scientists reviewed 20 studies involving nearly 11,000 people with and found something unexpected: antibiotics during pregnancy had less influence than the year before conception!

Key finding: Certain (macrolides, sulfonamides, tetracyclines) taken before getting had a greater association with their future children developing .

Why: Antibiotics affect gut bacteria, which may influence the baby's immune development from the start.

What it means: If you're planning pregnancy, discuss antibiotic use with your doctor. More research is needed to confirm timing, other influences and specific types.

Read the article online at🔗 https://doi.org/10.3389/fendo.2026.1764522

18/03/2026

“Thank heavens” says Teddy, “No more ENDIA”.

Teddy looked overjoyed to say goodbye to the ENDIA Team at the Children’s Hospital at Westmead. Not because he didn’t love seeing Rose and Dr Maria; he really did! But he won’t miss the needles and swabs, p**p and wee. And fair enough! That’s enough of that, Teddy.

Thank you so much to you and your family for everything. We will put all your information to extra special good use to try to find what causes .

Teddy sure loved his gold medal and certificate. Almost worth it in the end 😊

There is continued follow up available for ENDIANs who wish it through Type1Screen: www.type1screen.org or the new Australian Diabetes Antibody Program... more about that soon.

15/03/2026

Eldest ENDIAN from , Isabelle, graduated last year.

Congratulations and well done, Isabelle. You can see how proud her parents were of her .

And what a wonderful big sister moment to see her little sister, Adeline, start her first day at school earlier this year.

Good luck this year Isabelle and Adeline for your first year of and primary school respectively.

All the best to all our ENDIANs embarking on a new school year. Be your best selves.

Address

Women's And Children's Hospital
Adelaide, SA
5006

Website

http://www.endia.org.au/

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