01/11/2025
The retina at the back of the eye houses millions of light-detecting photoreceptors cells. 👁️ For people living with retinal degeneration – a group of diseases including age-related macular degeneration, retinitis pigmentosa and Stargardt’s disease – the death of these cells means a progressive loss of vision.
At CERA, Head of Cellular Reprogramming, Associate Professor Raymond Wong, is taking major steps towards restoring vision by using cell reprogramming to help the photoreceptors grow back. 🧬🔬
“We are working on a treatment to stimulate the stem cells in the eye to develop into new photoreceptors by injecting safe engineered viruses into the eye to deliver reprogramming genes,” says Associate Professor Wong.
Thanks to the support of CERA’s donors and the National Stem Cell Foundation of Australia – Associate Professor Wong’s team are scaling up towards developing treatments for retinal degeneration.
“With research at this stage, it’s difficult to find financial support as it doesn’t yet have a clear path to the clinic, but it’s absolutely necessary for the discovery of treatments,” he says.
“We wouldn’t be where we are today without our generous CERA donors who gave to us and continue to do so.”
In the research’s discovery phase, Associate Professor Wong received support from government and philanthropic organisations, including the National Health and Medical Research Council - NHMRC, Medical Research Future Fund (MRFF), National Stem Cell Foundation of Australia, CERA Foundation and Retina Australia.
After completing this phase, CERA established startup Mirugen to secure commercial partners to further support the research.
Last year, Mirugen received a $1.92m grant from biotech incubator CUREator+ – a national program funded by the Federal Government’s Medical Research Future Fund and delivered by Brandon BioCatalyst and AndHealth.
This year, Mirugen secured $4.5m in seed funding from a consortium of investors through The University of Melbourne Genesis Pre-Seed Fund, Tin Alley Ventures and Brandon Capital.
Associate Professor Wong says it's a huge moment for moving the research closer to the clinic. 🏥
“With this support, it shows there is hope from many people to make this treatment available to patients as soon as possible.”