MTHFR Support Global

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MTHFR Support Global

MTHFR Support Australia was created to provide support & raise awareness about MTHFR gene mutations & methylation. http://www.mthfrsupport.com.au

About MTHFR Support Australia:

Why did we decide to focus on MTHFR? Well we started to see more and more chronically ill people who had been to doctors , specialists and countless naturopaths and were just not getting the results they should have been. Individuals with a MTHFR mutation or disordered methylation are presenting with cardiovascular disease, chronic inflammation, depression, anxiety, Diabetes, autoimmune conditions, ADD/ADHD, Down's Syndrome, recurrent miscarriage and cancer- to name a few! We need to heal at a cellular level and what we now see is that nutritional methyl donors are restoring our patients health because we are breaking down the obstacles to healing and decreasing inflammation. We work with nutrition, co-factors and substrates required to bring the methylation cycle back into balance to reduce symptoms

Our learning always continues and it seems the more we know the more we need to know. We truly believe in a collaborative health care approach. The patient has to come first. We all have to try harder to ensure that sick people get better. We need to think outside the square and all put our heads together to ensure this works. We've seen this every day. We know this works. If you are a practitioner, join our PRACTITIONERS ONLY group: https://www.facebook.com/groups/MTHFRPractitionerMembersGroup

16/03/2026

🚨 Stop scrolling.
This tiny gene could influence more than you think

Most people know MTHFR as the “folate gene.” But what many don’t realise is that it may also influence things like:
🫀 affects blood vessel health
• weight gain or metabolic health
• fatty liver
• gut inflammation

The connection? A molecule in your body called homocysteine.

When homocysteine levels rise, it can:
🧠 increase inflammation
⚡ interfere with insulin signalling
🫀 affect blood vessel health

Over time, this may contribute to conditions like type 2 diabetes, metabolic syndrome, fatty liver and inflammatory gut conditions.

But here’s the important part:✨
What may help support this pathway?

Lifestyle, nutrition, and targeted support can help regulate homocysteine and support healthy methylation pathways.

What may help support this pathway
• leafy greens rich in folate
• foods containing B12 and choline (eggs, fish, legumes)
• checking homocysteine levels with a simple blood test
• supporting inflammation balance through diet and lifestyle

Understanding your genetics doesn’t mean something is “wrong.”

It simply gives you better information to support your health.

💬 Have you ever checked your homocysteine levels?

15/03/2026

🌿 Mindful Monday: if you feel anxious after eating… it might not be anxiety

Ever noticed this? You eat a meal or snack and shortly after you feel:
• shaky
• irritable
• anxious
• foggy
• suddenly very tired

You eat a meal or snack, and shortly after, you feel::etimes it’s something else entirely.

👉 A blood sugar spike followed by a crash.

When glucose rises quickly and then drops, the body releases stress hormones like adrenaline to stabilise it, which can feel a lot like anxiety.

🍽️ A Simple Mindful Eating Check

Before your next meal or snack, pause and ask:

“Will this keep my energy steady?”

Adding protein, fibre, or healthy fats can help slow glucose spikes and support a calmer nervous system.

Examples:
✨ Apple with nut butter
✨ Eggs with vegetables
✨ Yogurt with seeds
✨ Hummus with carrots

Small shifts can make a big difference to how you feel after eating.

Why this matters

🧠 Blood sugar influences mood and focus
⚡ Rapid spikes can trigger adrenaline
🌿 Stable energy supports nervous system balance

A gentle reminder

Sometimes what feels like anxiety… is simply your body asking for steadier fuel.

💬 Have you ever noticed mood shifts after certain meals?

14/03/2026

Great meeting all the praccies at today's Vital.ly event "Re:formulate" today where I spoke about compounding. If you are here come and say hi.

12/03/2026

⚠️ You could have MTHFR and not know it.

Millions of people carry an MTHFR gene variant, yet many go years without understanding why their body reacts differently to stress, supplements, or medications.

Because MTHFR affects methylation, a core process your body uses to:
🧠 regulate mood and neurotransmitters
⚡ produce energy in your cells
🧬 repair DNA and support detox pathways
💉 process folate and B-vitamins
❤️ regulate homocysteine and cardiovascular health

When this pathway isn’t working efficiently, people often notice patterns like:
• feeling worse on certain supplements
• fatigue that doesn’t improve with rest
• anxiety or mood swings
• headaches or brain fog
• sensitivity to medications or detox programs

But here’s the important part: MTHFR isn’t a disease.

It’s simply a genetic variation that may change how your body processes nutrients and toxins.

And once you understand it, you can support the pathway in ways that work with your biology, not against it.

Many people tell us the biggest relief is finally understanding:
“Why does my body react differently than everyone else?”

💬 Have you ever reacted badly to a supplement that was supposed to help?

11/03/2026

When detox protocols make your patient worse… It’s usually not the toxins.

Rebecca was 41 and had been sick for two years.

Fatigue. Brain fog. Chemical sensitivities. Severe cognitive decline.

Three practitioners suspected exposure to mould, so they did what most of us would do. They started detox protocols.

Glutathione.
Binders.
Liver herbs.
Sauna.

And every intervention made her worse.
⚠️ This wasn’t a detox reaction.
This was genetics colliding with detoxification pathways.

When we ran her genomic panel, the pattern became clear:
• MTHFR compound heterozygous → impaired methylation
• COMT slow → poor catecholamine clearance
• GSTM1 deletion → missing a key glutathione detox enzyme
• GSTP1 variant → reduced glutathione function
• UGT + SULT variants → impaired Phase II detox
• CBS upregulation → methylation depletion

The issue wasn’t mould.
The issue was that her detox pathways couldn’t process what practitioners were mobilising.

Toxins were being released…but her body couldn’t conjugate and eliminate them. So they redistributed instead.

When we slowed the right pathways and opened the blocked ones in the correct order, everything changed.

Month 1: no longer deteriorating
Month 4: brain fog lifting
Month 9: back to work
Month 12: full recovery

The variants themselves weren’t rare. The breakthrough was understanding the pattern.

And that’s exactly what we practice inside the Genetics Collective - working through real cases together to develop clinical genomic integration.

🧬 If you want to build real pattern-recognition skills in genomics, join us inside the Functional Genomics Institute. Click on the link below or in the bio: https://www.mthfrsupport.info/functional-genomics-institute

10/03/2026

🍽️ Wellness Wednesday: How blood sugar spikes affect your mood and mental health

Ever notice how you feel great after a sugary snack… and then suddenly irritable, tired, or anxious a little while later?

That’s often your blood sugar on a rollercoaster. And it can have a big impact on your mood and mental clarity.

🧠 What happens when blood sugar spikes

When you eat foods high in refined carbohydrates or sugar, glucose enters your bloodstream quickly. Your body releases insulin to bring those levels down.

But if the spike is sharp, the drop can be just as sudden.

This rapid rise and fall can affect how your brain functions and how you feel emotionally.

🔄 the mood rollercoaster
When blood sugar crashes after a spike, you may experience:
• irritability
• anxiety or jitteriness
• fatigue and brain fog
• difficulty concentrating
• sugar or caffeine cravings

Your brain relies on a steady supply of glucose to function well. When levels fluctuate too much, mental energy and emotional regulation can suffer.

🧬 Why stability matters for mental health

Stable blood sugar supports the production and balance of important neurotransmitters like serotonin and dopamine, which help regulate mood, motivation, and focus.

Frequent spikes and crashes can increase stress hormones like cortisol and contribute to inflammation, which may worsen symptoms of anxiety, low mood, and fatigue.

🌱 How to keep blood sugar steady

Small habits can make a big difference:
✨ eat protein, healthy fats, and fibre with meals
✨ avoid starting the day with sugary foods alone
✨ choose whole foods over highly processed snacks
✨ move your body after meals when possible
✨ eat regularly to avoid large dips in blood sugar

Supporting balanced blood sugar doesn’t just help energy levels; it helps support your brain, mood, and resilience throughout the day.

💬 Have you noticed how certain foods affect your mood or energy?

09/03/2026

⚠️ 3 signs your blood sugar is spiking (even if you don’t have diabetes)

Blood sugar spikes don’t always look like what people expect.
Often, they show up as everyday symptoms that many people ignore.

Here are three common clues that your glucose may be rising and crashing throughout the day:
1️⃣ Afternoon energy crashes
If you feel focused after eating but crash hard a few hours later, it may be your blood sugar dropping after a spike.

2️⃣ Intense sugar or carb cravings
When glucose swings rapidly, your brain signals the need for quick energy, often leading to cravings for sweets, bread, or caffeine.

3️⃣ Brain fog or irritability between meals
The brain depends heavily on stable glucose levels. When they fluctuate, concentration, mood, and mental clarity often suffer.

Blood sugar regulation isn’t just about diabetes risk.
It affects energy, mood, focus, inflammation, and long-term metabolic health.

Supporting stable blood sugar through balanced meals, protein, fibre, movement, and stress management can make a significant difference.

Sometimes the symptoms we normalise are simply signals the body needs more stability.

💬 Do you ever notice energy crashes or sugar cravings during the day?

08/03/2026

🌿 Mindful Monday: blood sugar affects your mood more than you think

Ever noticed how you can go from:
• calm → anxious
• focused → foggy
• patient → irritable

…within a couple of hours?

Sometimes it’s not your mindset.
👉 It’s your blood sugar.

When blood sugar rises and crashes quickly, it can trigger fatigue, cravings, anxiety, and brain fog.

🍽️ A simple mindful eating tip for stable energy
Before your next meal or snack, pause and ask:
“Does this have protein, fibre, or healthy fat?”

Adding even one of these can help slow glucose spikes and support steadier energy.
Examples:
✨ Apple + nut butter
✨ Eggs with toast
✨ Yogurt with seeds
✨ Veggies with hummus

Small adjustments make a big difference.
Why does this matter?
🧠 Blood sugar impacts mood + focus
⚡ Big spikes often lead to energy crashes
🌿 Stable energy supports hormone and nervous system balance

A gentle reminder"
You don’t need a perfect diet.
You just need steady fuel.

💬 Have you noticed how food affects your mood or energy?

05/03/2026

🧠 Copper & iron: it’s about regulation, not just levels.

Copper and iron don’t work in isolation.

Copper is required to help mobilise and utilise iron properly. Without adequate copper, iron can accumulate in tissues but fail to function effectively, which may contribute to fatigue, low resilience, or poor oxygen delivery.

But balance matters.

Too little copper can impair:
• Iron metabolism
• Red blood cell formation
• Mitochondrial energy production
• Neurotransmitter synthesis

Too much, especially without proper regulation, may influence mood stability, oxidative stress, or inflammatory signalling.

And here’s where it gets more interesting:

🧬 Genetics can influence how well you regulate copper.
Variants affecting methylation, detoxification, and oxidative stress pathways can alter how minerals are processed and balanced in the body.

It’s not just about intake.
It’s about utilisation.

⚖️ Factors that can influence copper balance:
• High-dose zinc supplementation
• Restrictive or low-variety diets
• Digestive absorption issues
• Genetic variations affecting detox and methylation

Copper also plays a role in enzymes involved in dopamine and norepinephrine production, meaning energy, motivation, and stress tolerance can all be influenced by proper mineral balance.

Before supplementing, assess the system.

Mineral balance is nuanced, and context matters.

04/03/2026

🧬 When MTHFR is just the beginning

Three miscarriages.
Perfect labs.
“Bad luck,” she was told.

Michelle was 34 when she came to my clinic after losing three pregnancies at 7–9 weeks.

Her OB had already tested MTHFR C677T homozygous.
She was on methylfolate.
Standard protocol.

She still miscarried.

Because MTHFR wasn’t the full story. When I ran a comprehensive panel, this is what emerged:
• MTHFR C677T homozygous
• TCN2 homozygous (reduced B12 transport)
• MTRR A66G homozygous (impaired B12 recycling)
• COMT fast (methyl depletion)
• GSTM1 deletion
• TYMS homozygous (high folate demand)
• Factor V + PAI-1 variants

This wasn’t “just methylation.”
It was a methylation system collapse.

She was taking 800mcg methylfolate, but with impaired B12 recycling and increased TYMS demand, it wasn’t enough.

Her homocysteine was still 14 μmol/L.
Optimal for pregnancy?

03/03/2026

💧 Wellness Wednesday: hydration vs electrolytes. What do you actually need?

You’re drinking more water… but still feeling tired, headachy, or foggy?

Here’s the thing 👇
Hydration isn’t just about water.
It’s about fluid + minerals.

💦 water = fluid

Water helps regulate temperature, supports detox, keeps blood volume stable, and aids di digestion. But when you sweat (hello Aussie summer ☀️), exercise, drink alcohol, or experience stress… You don’t just lose water. You lose electrolytes, too.

⚡ Electrolytes = the minerals that make hydration work

Electrolytes include:
• sodium
• potassium
• magnesium
• chloride

They help regulate:
🧠 nerve signals
💪 muscle contractions
❤️ heart rhythm
🧬 cellular energy

Without enough electrolytes, water alone can leave you feeling flat.

🧠 Signs you might need electrolytes (not just water)
• headaches
• muscle cramps
• fatigue
• brain fog
• dizziness
• feeling “dehydrated” despite drinking plenty

🌿 What you actually need
on low-sweat, indoor days → 💧 water + whole foods is usually enough.

On hot, sweaty, stressful days → ⚡ add electrolytes or mineral-rich foods like leafy greens, avocado, coconut water, and quality salt.

Balance is more powerful than extremes.
✨ Hydration isn’t about chugging more.
It’s about giving your cells what they actually need.

💬 Be honest. Are you under-hydrated or under-mineralised?

02/03/2026

It was 10 pm on a Tuesday.
I was alone in my clinic, staring at a complex fertility case that didn’t fit any textbook pattern.

Recurrent pregnancy loss. “Normal” pathology.
But her genetic report told a different story:
MTHFR C677T homozygous.
COMT variants.
Clotting genes.
CBS upregulation.

Individually, I understood these genes.

What I was wrestling with was integration.

Which variants were clinically relevant?
Which was background noise?
What was the treatment hierarchy?
Where do you start when everything looks important?

This is the real challenge in genomics.

Not memorising pathways.
Not learning what MTHFR does.

But developing pattern recognition, the ability to see how methylation, detoxification, neurotransmitters, inflammation and hormones intersect in one patient.

That skill isn’t built in isolation.

It’s built in discussion.
In case dissection.
In collaborative reasoning with clinicians who understand the language of genomics.

That’s why I created the Genetics Collective, a live, interactive workshop designed exclusively for practitioners ready to move beyond theory and into real clinical integration.

We don’t review genes in isolation.
We work through a complex case together.
You interpret the genetic report.
You identify priority pathways.
You build a treatment strategy.
Then we compare, refine, and expand.

This is how confidence is built.

Not by passively consuming content, but by thinking through real cases in real time.

If you’re ready to strengthen your genomic pattern recognition and join a community of practitioners who speak this language fluently, the Genetics Collective is your next step.

🔬 Join us on March 6th and build the skill that transforms complex cases into a clear strategy.
Secure your place here:
👉 https://loom.ly/4h4J1g4

**You need to be an active member of the Functional Genomics Institute by March 5th to participate.

Address

40 Yeo Street
Crows Nest, NSW
2089

Telephone

+61299081888

Website

http://www.mthfrsupport.com.au/

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Our Story

About MTHFR Support Global: Why did we decide to focus on MTHFR? Well we started to see more and more chronically ill people who had been to doctors , specialists and countless naturopaths and were just not getting the results they should have been. Individuals with a MTHFR mutation or disordered methylation are presenting with cardiovascular disease, chronic inflammation, depression, anxiety, Diabetes, autoimmune conditions, ADD/ADHD, Down's Syndrome, recurrent miscarriage and cancer- to name a few! We need to heal at a cellular level and what we now see is that nutritional methyl donors are restoring our patients health because we are breaking down the obstacles to healing and decreasing inflammation. We work with nutrition, co-factors and substrates required to bring the methylation cycle back into balance to reduce symptoms Our learning always continues and it seems the more we know the more we need to know. We truly believe in a collaborative health care approach. The patient has to come first. We all have to try harder to ensure that sick people get better. We need to think outside the square and all put our heads together to ensure this works. We've seen this every day. We know this works.