MTHFR Support Global

06/11/2025

🧬 SNP spotlight: MTHFD1 - the gene that powers methylation and DNA repair

Meet the multitasking enzyme that keeps your cells healthy.
MTHFD1 converts folate into the active forms needed for:
✨ Methylation
✨ DNA synthesis
✨ Energy + redox balance

But when SNPs like rs2236225 (R653Q) slow this process, the effects ripple across the body, from fatigue and fertility issues to elevated homocysteine and anaemia.

🚨 Functional red flags:
🔺Poor tolerance to folic acid
🔺Recurrent miscarriage or NTD history
🔺Unexplained fatigue or high homocysteine
🔺Placental or methylation-related complications

💡 Support the cycle:
5-MTHF, folinic acid, B12, P5P, choline, betaine, antioxidants + NADPH support.

When MTHFD1 functions properly, everything else flows more smoothly: your methylation, your mood, and your mitochondria.

05/11/2025

💔 It’s not always her. Sometimes, it’s his DNA.

For decades, recurrent pregnancy loss (RPL) has focused on the mother's hormones, egg quality, and uterine health.
But new research in Medicina (2024) reveals a powerful truth:
♂️ Paternal factors can be just as important.

🧬 What the study found:
👉 High s***m DNA fragmentation (DFI) can double miscarriage risk.
👉 Paternal metabolic issues - obesity, diabetes, hypertension - predict pregnancy loss even when maternal factors are normal.
👉 Advanced paternal age (>40) increases miscarriage risk up to 43%.
👉 Y-chromosome microdeletions and s***m proteomic patterns (like reduced HK1 and helicase proteins) may reveal hidden drivers of embryo loss.

🌿 The mechanisms:
❗Oxidative stress damages s***m DNA
❗Epigenetic instability disrupts early embryo development
❗Metabolic and toxin overload alter s***m protein expression
❗Methylation imbalances reduce embryo repair capacity

👨‍⚕️ What this means for clinical practice:
Reproductive health is a shared responsibility.
Testing s***m health, oxidative stress, and genetic variants should be standard in couples with ≥2 miscarriages.

💡 Functional takeaways:
🥗Support mitochondria + antioxidants (C, E, CoQ10, NAC, zinc, selenium)
💚Optimise metabolic health (HbA1c, BMI, lipids, blood pressure)
🚭Reduce toxin exposure (smoking, alcohol, plastics, pesticides)
🧬Allow 90 days (one s***matogenic cycle) for a full preconception reset

👨‍🍼It’s time to evolve beyond a “female-only” fertility lens and start seeing RPL as a couple’s condition.

📚 Reference:
Kaltsas, A. et al. (2024).Paternal Contributions to Recurrent Pregnancy Loss: Mechanisms, Biomarkers, and Therapeutic Approaches. Medicina, 60(10).

05/11/2025

🌈 Reach for the Rainbow, Your Cells Will Thank You! 🌈

Did you know the colours on your plate can literally change how your genes express themselves? 🤯

Each colour in fruits and veggies packs unique plant compounds (phytonutrients) that protect your body from inflammation, oxidative stress, and even DNA damage, especially important if you have an MTHFR variant or impaired detox pathways! 💪

Here’s why every colour counts 👇

🤍🤎 WHITE & BROWN:
Think onions, garlic, mushrooms, parsnips 🍄🧅
Contain allicin, quercetin & kaempferol - antioxidants that fight tumours, balance cholesterol, and boost immune defence.

🧡💛 ORANGE & YELLOW:
Carrots, sweet potatoes, oranges, pineapple 🍊🥕🍍
Packed with beta cryptoxanthin - supporting heart health and cellular communication (hello, glowing skin ✨).

❤️ RED:
Tomatoes, strawberries, cherries, red capsicum 🍅🍓🍒
Rich in lycopene, which protects your heart and may reduce certain cancer risks.

💚 GREEN:
Broccoli, kale, herbs, spinach, green tea 🥦🌿🍵
Loaded with sulforaphane and indoles - these help your liver detoxify hormones and neutralise carcinogens.

💙💜 BLUE & PURPLE:
Blueberries, eggplant, grapes 🍇🍆
Full of anthocyanins that support memory, heart health, and slow cellular ageing.

👉 Pro tip: Keep the skins on! That’s where most phytonutrients live 🍏🍑🍆

So next time you eat, think: How many colours can I get on this plate? 🌈

Because diversity in colour = diversity in nutrients = diversity in gut microbes 🧬✨

02/11/2025

🌬️ Mindful Breathing: The Pause That Heals 🌬️

In a world that moves too fast, your breath is always there, a quiet anchor back to balance.
Taking just a few slow, conscious breaths can calm your nervous system, lower stress hormones, and support healthy methylation and neurotransmitter balance, which is especially important for individuals with MTHFR or COMT variants.

✨ Try this today:
1️⃣ Inhale slowly for 4 counts
2️⃣ Hold for 4 counts
3️⃣ Exhale for 6 counts
4️⃣ Repeat 3–4 times

Each breath is a reminder, you can’t control everything, but you can always return to yourself. 💚

30/10/2025

⚠️ This is the part most practitioners get wrong.
When you cut oxalates too quickly, the body doesn’t just “detox”. It dumps stored crystals that slice through tissues on their way out.

💥 What you might see:
🔥 Burning urine
💧 Joint or muscle pain
🩸 Crystals in stool or skin eruptions
🧠 Fatigue or headaches

This isn’t healing. It’s harm.
🔬 Safe oxalate reduction means:
✅ Gradual dietary changes
✅ Proper calcium citrate timing
✅ Supporting bile, kidney, skin & gut elimination
✅ Monitoring kidney function (EGFR should improve, not decline)

✨ When done right, results can be life-changing, like Carolyn’s patient whose pregnancy complications resolved in 48 hours after a gentle adjustment.

🧠 Want to master this safely?
Our Oxalate Training teaches the complete safety protocol, genetic interpretation, and timing for every phase of recovery.

🎓 Enrol now. 48-hour sale ends soon!
👉 Link: www.mthfrsupport.info/products/233598-Oxalates

29/10/2025

⏳ 48 HOURS LEFT!!! Transform How You Treat Oxalate Issues

Practitioners everywhere are realising one thing:
👉 Oxalates aren’t just a dietary issue; they’re a genetic and biochemical challenge.

If you’ve been following our latest educational posts on glyphosate, genetics, and oxalate overload… this is your next step.

Enrol now in Carolyn Ledowsky’s Complete Oxalate Practitioner Training and get instant access to:
🎥 Multiple recorded webinars
🧬 Genetic interpretation frameworks (AGXT, GRHPR, HOGA1, SHMT, MTHFR + more)
🧩 Real case studies
📄 Patient-ready handouts & food charts
👩‍🍳 Bonus low-oxalate recipe eBook

💡 Here’s what you’ll achieve in weeks, not months:
✅ Recognise oxalate patterns in complex patients
✅ Implement safe protocols & avoid “detox crash”
✅ Confidently integrate genetics into every treatment plan

🎯 Special pricing (until midnight Oct 31):
💲$99 for full access (normally $297)
💲$47 for Functional Genomics Institute members

Don’t miss this opportunity to future-proof your clinical toolkit.

👉 Enrol now: https://loom.ly/k75oXS0

28/10/2025

❗Your liver does more than detox; it methylates, too.

Your body detoxes daily, but methylation is the engine behind it.
🧬When MTHFR or related genes are sluggish, toxins can build up faster than your body clears them.

🔬 Common overload signs:
⚡ Fatigue that doesn’t go away
🌿 Sensitivity to smells or chemicals
😣 Headaches or skin flare-ups after “detoxing”

💡 Support your detox pathways by:
Optimising methylation nutrients (B2, B6, folate, B12, choline)
Including cruciferous vegetables 🥦
Reducing toxin exposure (glyphosate, plastics, fragrances)

🧩 Your genes influence how well you clear what you’re exposed to. Understanding them helps you detox smarter, not harder.

27/10/2025

27/10/2025

Did you know the world’s most common herbicide can turn into oxalate inside your body? 😮

Here’s why that matters, especially if you or your patients have MTHFR or methylation issues.

🧬 The science simplified:
Glyphosate (Roundup) breaks down into glyoxylate, which, under stress or genetic weakness (like AGXT variants), can convert directly to oxalate - the same compound that drives kidney stones, inflammation, and pain.

But that’s not all 👇
Glyphosate also binds essential nutrients needed for oxalate metabolism: manganese, zinc, B6, and iron.
Result? The body can’t detox properly, and oxalates build up.

🔥 The “perfect storm” for MTHFR patients:
Ongoing fatigue or joint pain even with “clean eating”?
Worsening gut symptoms after switching to “healthy” whole foods?
Children or adults who react strongly to oxalate-rich diets (spinach, nuts, sweet potatoes)?

👉 Glyphosate exposure may be the missing link.

💡 What’s more:
Oxalates and sulphates share the same transporter (SAT1).
When oxalates build up, sulphate - essential for detox, neurotransmitters, and hormones - is dumped.
That means methylation alone won’t fix the imbalance.

🌎 Where it’s found:
☔ 75% of air and rain samples
🌾 Most non-organic grains and legumes
🥩 Conventional animal products

This explains why some of your most compliant patients plateau despite perfect supplementation and diet.

🧩 The takeaway:
Environmental toxicity can directly influence methylation and oxalate metabolism. Addressing glyphosate exposure is just as important as supporting MTHFR function.

🎓 Want to master genetic interpretation for oxalate cases?
Carolyn’s comprehensive training covers the glyphosate–oxalate connection and how to assess + mitigate environmental exposure.

🔗 Training link in bio or visit: https://loom.ly/k75oXS0

26/10/2025

Ever noticed how a short barefoot walk can instantly calm your mind? 🦶💚
It’s not just a vibe, it’s biochemistry and physics.

Here’s how it works 👇
🌍 Grounding (earthing) allows your body to absorb free electrons from the Earth.
These electrons act as natural antioxidants, helping reduce oxidative stress and inflammation.

🧠 For those with MTHFR or methylation imbalances, grounding can support:
✨ Lower stress reactivity
✨ Improved sleep quality
✨ Better nervous system regulation
✨ Enhanced parasympathetic activity (“rest and digest” mode)

Even 10 minutes a day can shift your body from fight-or-flight to repair-and-reset.

💡 Mindful reminder: The best medicine sometimes isn’t in a bottle, it’s beneath your feet.

23/10/2025

Two patients.
Same diet.
Same symptoms.
Same “oxalate detox” protocol.

However, one improved... and the other deteriorated significantly. 😬

Here’s what made the difference 👇

✨ Patient B carried variants in the AGXT gene, meaning her body couldn’t process oxalates properly.
Instead of healing, every “healthy” green smoothie pushed her deeper into inflammation.

This is why genetics matters.

🧩 Here’s what your genes can reveal about oxalate sensitivity:
🔹 AGXT variants: Need high-dose B6 + strict oxalate restriction (B6-dependent enzyme).
🔹 GRHPR variants: Show elevated glyoxylic acid, need NADPH and antioxidant support.
🔹 HOGA1 variants: Must avoid collagen, which breaks down into oxalate precursors.
🔹 SLC26A family: Determines how much oxalate is absorbed from food.
🔹 SHMT + MTHFR variants: Impair glycine metabolism → increased oxalate risk.

💥 Real story: One woman lost both knees and a hip to oxalate-related damage before her genetics explained why standard care failed her.

🧬 The takeaway:
If someone isn’t responding to “clean eating” or low-oxalate protocols… look deeper.
Genes like AGXT, SHMT, and MTHFR can hold the missing piece.

🔍 Want to learn how to read these patterns?
Join our functional genomics education hub at MTHFR Support Institute, or get our Genetic SNPs training here:https://loom.ly/k75oXS0

22/10/2025

We often talk about folate and B12 when it comes to methylation, but there’s another nutrient quietly running the show: Vitamin B6, or more precisely, its active form Pyridoxal 5’-Phosphate (PLP).

PLP isn’t just another “B vitamin.” It’s a biochemical powerhouse. ⚡
It supports over 70 enzymatic reactions, including:
🧬 Neurotransmitter synthesis (serotonin, dopamine, GABA)
🌿 Methylation & detox pathways (CBS, BHMT, and transsulfuration)
💥 Energy regulation & glucose control
🩸 Red blood cell formation and heme synthesis

But here’s what most people, and even clinicians, overlook 👇
PLP is fragile.
It’s easily inactivated by:
⚠️ Certain medications (e.g. isoniazid, hydralazine, penicillamine)
⚠️ Oxidative or aldehyde stress
⚠️ Genetic variants in PNPO, ALDH7A1, or PLPBP

When PLP falters, symptoms ripple across multiple systems:
😴 Fatigue and poor stress tolerance
💭 Anxiety, depression, or OCD
🔥 High homocysteine and poor methylation
🧠 Neuropathy or seizure susceptibility

💡 Clinical insight:
Sometimes, it’s not about how much B6 you take, but rather how well your body can activate and utilise it.

✨ Nutrients work as a network. If PLP is low, folate and B12 can’t do their jobs effectively either.

📚 Read more:
Wilson et al., Journal of Inherited Metabolic Disease (2019).
https://doi.org/10.1002/jimd.12071