29/01/2026
Important New POTS Research Findings:
https://www.biorxiv.org/content/10.64898/2025.12.29.696828v1
We’re proud to share the results of a new research study funded by Standing Up to POTS — made possible by the generosity of our donors 💙
This study by Dr. Resia Pretorius, Dr. Satish Raj and colleagues explored a novel biological pathway that may help explain why POTS symptoms occur and how POTS may differ from Long COVID at a molecular level.
🔬 What did the researchers study?
They examined tiny, abnormal protein clumps in the blood called fibrinaloid microclots. These microclots can interfere with blood flow in the smallest blood vessels and may contribute to reduced oxygen delivery to tissues.
🧪 What did they find?
The researchers discovered that:
• People with pre-COVID POTS had distinct molecular changes within these microclots
• These changes were different from those seen in Long COVID, and also different from Long COVID with POTS
• This suggests POTS may have its own biological signature, rather than being solely a nervous-system disorder
🧠 Why does this matter?
If confirmed in future studies, these findings could:
• Improve understanding of the biological mechanisms behind POTS
• Help guide the development of objective tests or biomarkers
• Open the door to new treatment strategies that go beyond symptom management
This research builds on earlier work proposing that microcirculatory dysfunction may play a role in POTS (see https://www.mdpi.com/2075-4426/14/2/170)— and begins to test that idea with real molecular data.
⚠️ Important note:
This is a pre-print still awaiting peer review, and does not yet change clinical care. More studies are needed to confirm and expand these findings. But this is the kind of foundational work needed to move the field forward.
💙 We are deeply grateful to our donors.
This study — and many others — would not be possible without you. Your support allows Standing Up to POTS to fund innovative research aimed at better answers, better treatments, and a better future for people living with POTS. To see other research we’ve funded, visit https://www.standinguptopots.org/research-fund/funded-research-studies