Garvan Institute of Medical Research

Garvan Institute of Medical Research Garvan Institute of Medical Research is a world leader, pioneering study into some of the most widespread diseases of today.
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It aims to understand the genetic, molecular and cellular processes of health and disease as a basis for developing future cures.

Pancreatic cancer affects thousands of Australian families each year. November is Pancreatic Cancer Awareness Month. We’...
10/11/2025

Pancreatic cancer affects thousands of Australian families each year. November is Pancreatic Cancer Awareness Month. We’ll be sharing information about the disease, spotlighting Garvan’s research progress over the years, and introducing our researchers who are leading new approaches to early detection and treatment of this cancer. Join us as we work towards a future where pancreatic cancer is no longer a ‘silent’ threat. 💜

Learn more about pancreatic cancer: https://www.garvan.org.au/research/diseases/pancreatic-cancer?utm_source=facebook&utm_medium=social_organic&utm_campaign=ourstories&utm_content=10112025_101125_bev_story_post_1

A new mutation causing autoimmunity found.Garvan researchers have discovered a new gene mutation that causes an autoimmu...
07/11/2025

A new mutation causing autoimmunity found.

Garvan researchers have discovered a new gene mutation that causes an autoimmune condition called APECED. This condition leads to:

- a range of disturbances around the body as hormone-producing organs are attacked by the immune system
- less ability for the immune system to fight fungal infections (thrush) in several parts of the body, leading to recurrent infections.

The condition is caused by mutations in the AIRE gene which is essential for the immune system to be able to distinguish between the body’s own cells and foreign invaders – and prevent autoimmunity.

For many years, scientists knew that someone had to have a mutation in both sets of AIRE genes (one from the mother and one from the father) to get the condition.

But now, researchers and clinicians of the Clinical Immunogenomics Research Consortium of Australasia (CIRCA), co-led by Professor Stuart Tangye at Garvan and Associate Professor Alberto Pinzon-Charry at Queensland Children’s Hospital, have discovered a new APECED-causing mutation that only needs to occur on one copy of the AIRE gene to cause disease.

This new form of APECED is milder and unlike other forms, doesn’t lead to recurrent thrush.

This is the first time this gene variant has been seen in APECED.

This discovery should fast-track the diagnosis of more people with this autoimmune condition, allowing them to receive treatment faster.

Read more: https://ow.ly/RH7r50Xlx7o

07/11/2025

What an incredible day in honour of Josh Avvenevole 💙

The annual Heart of the Green Gold Day brought together an amazing community to raise $150,000 for Professor Jodie Ingle’s research into Sudden Cardiac Death in the young (SCDY).

Josh’s legacy continues to inspire life changing research.

A genetic diagnosis changed Stella’s life forever. 🩺For the first 18 months of her life, Stella’s family searched desper...
05/11/2025

A genetic diagnosis changed Stella’s life forever. 🩺

For the first 18 months of her life, Stella’s family searched desperately for answers to her severe, recurrent skin infections. Finally, the team at CIRCA, a Garvan-based research program co-led by Professor Stuart Tangye, helped diagnose Stella with a rare immune disease. Receiving the diagnosis quickly enabled a bone marrow transplant that transformed her life.

Professor Tangye and his colleagues are working hard to uncover the genetic causes of rare immune diseases, providing patients like Stella with access to life-changing diagnoses, sooner.
Please donate today to help Garvan continue this vital work, giving families the answers they desperately need.

👉 Support our research: https://ow.ly/6Vko50XjsjW

05/11/2025

In cancer, where previously our options were limited to surgery, chemotherapy and radiotherapy, we’re now hearing terms like cancer immunotherapy, targeted therapies and even cancer vaccines.

Many of these are what we call biologics.

In our new podcast episode of Medical Minds, you’ll hear from Dr Rachel Galimidi who is at the forefront of biologics drug development and is working to make new and better treatments for a range of diseases.

To listen to the full episode, go to Apple or Spotify.

You can also listen to the episode here: https://ow.ly/g2Bp50XlwL9

Exciting clinical trial news! A liver cancer clinical trial is currently recruiting people to test whether a combination...
04/11/2025

Exciting clinical trial news!

A liver cancer clinical trial is currently recruiting people to test whether a combination therapy in early-stage liver cancer can stop the disease from returning.

The trial, called DEFINERx050, is being co-led by Garvan’s Dr Ankur Sharma and Professor Jacob George from The Westmead Institute for Medical Research at Westmead Hospital. It will test two drugs called bevacizumab and atezolizumab which act on the environment surrounding liver cancer cells.

This first-of-its-kind trial is recruiting across five states and 12 hospitals around Australia.

Shortly after Stella was born, she developed a severe, inexplicable skin condition. For 18 months, her family searched d...
31/10/2025

Shortly after Stella was born, she developed a severe, inexplicable skin condition. For 18 months, her family searched desperately for answers, consulting countless specialists as no one could explain what was causing her recurrent skin infections.

Finally, Stella was referred to CIRCA, a Garvan-based research program co-led by Professor Stuart Tangye. Through genetic testing, the team diagnosed Stella with a rare immune disease called DOCK8 deficiency. This crucial discovery led to a successful bone marrow transplant that completely transformed Stella’s life. ✨

Professor Tangye and his team at Garvan are dedicated to continuing this critical work, uncovering the genetic causes of rare immune diseases and enabling better access to life-changing diagnoses for patients just like Stella.

👉 You can help us give more families the answers they desperately need.

Find out more: https://ow.ly/nl0B50Xjq67

30/10/2025

Inborn errors of immunity (IEIs) are a group of rare immune diseases caused by single gene disruptions. Patients often endure recurrent infections, autoimmunity and, in some cases, cancer.
The diagnosis rate is low: currently, only about 35% of people with IEIs receive a diagnosis.

👉 Garvan researchers are fighting to boost that rate to 70%. Learn how you can help: https://ow.ly/b2kq50Xk4U8

Did you miss out on a place in the 2026 Sydney Marathon? You can still secure one of the limited remaining spots on Team...
29/10/2025

Did you miss out on a place in the 2026 Sydney Marathon?

You can still secure one of the limited remaining spots on Team Garvan.
Apply today and .

👉 Click here: https://ow.ly/T8Hu50Xjsim

29/10/2025

Tomorrow: Learn how genetic testing is transforming mysterious childhood illnesses into treatable conditions.

Join us for a public seminar featuring Prof Stuart Tangye, Dr Shruti Swamy, and parent advocate Nico Roux, whose daughter Stella was one of only five Australians diagnosed with DOCK8 immunodeficiency syndrome through genetic testing.

Many children with rare immune diseases face years of unexplained symptoms: recurring infections, mysterious rashes, chronic inflammation. These conditions, called inborn errors of immunity, affect over 560 different genes, making diagnosis extremely challenging.

The difference a genetic diagnosis makes, though, is life-changing. It can reveal targeted treatment options when they exist, guide medical management, and help families understand what they’re facing – even when treatments are still being developed.

Hear how Garvan and CIRCA (Clinical Immunogenomics Research Consortium Australasia) are using genomic sequencing to identify these rare conditions and connect families with effective treatments.

📅 Thursday 30 October
⏰ 10:30am AEDT
📍 Garvan Auditorium or online
🔗 Register: https://ow.ly/Peat50Xi8xh

Perfect for anyone interested in precision medicine and rare disease diagnosis.

Address

384 Victoria Street
Darlinghurst, NSW
2010

Opening Hours

Monday 9am - 5pm
Tuesday 9am - 5pm
Wednesday 9am - 5pm
Thursday 9am - 5pm
Friday 9am - 5pm

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