20/02/2026
Leaky colon is less well-known than leaky gut (small intestinal hyperpermeability), but equally important.
With a leaky colon, the colonocytes break down, allowing inflammatory compounds to leak into the bloodstream. This can include environmental toxicants that your gut is trying to eliminate, bacterial toxins, and even hormones.
Once they enter the bloodstream, your detoxification system must work again to remove them from your body.
A major factor in leaky colon is not producing enough butyrate by the bacteria in the colon. Butyrate is the primary food for your colonocytes, and without sufficient amounts, they starve and no longer function the way they should.
Prebiotic and fiber-rich foods, as well as resistant starches, help your butyrate-producing microbes make butyrate!
If you're a clinician and want to learn more about lesser-known but clinically crucial issues like leaky colon and how to treat them, be sure to enrol in our spring cohort of the Naturopathic & Functional Medicine Approaches to Gastrointestinal Disorders Course. https://probiotic-advisor.teachable.com/p/naturopathic-functional-medicine-approaches-to-gastrointestinal-disorders-2026-term
Early bird enrolment ends soon!