22/02/2026
❤️💧 Vasopressin & Heart Failure
Understanding the hormone–heart connection
Vasopressin plays an important role in fluid balance, but when levels stay elevated, it can contribute to heart failure progression; especially in more advanced disease.
Here’s what’s happening 👇
• Heart failure occurs when the heart can’t pump enough blood to meet the body’s needs
• In response, the body activates several compensatory systems, including:
– The renin–angiotensin–aldosterone system (RAAS)
– The sympathetic nervous system (SNS)
– The vasopressin system
⚠️ While these systems are meant to help short term, chronic activation causes problems.
Elevated vasopressin leads to:
• Water retention, increasing fluid in the bloodstream
• Vasoconstriction, narrowing blood vessels
• Increased cardiac workload, forcing the heart to work harder
💔 In people with heart failure, this extra fluid can worsen swelling, congestion, and shortness of breath, while the increased blood returning to the heart places additional strain on an already weakened muscle.
Understanding vasopressin’s role helps explain why hormonal balance and fluid management are so critical in heart failure care.
❤️🧠