ENDIA

Australia's largest study into the cause of type 1 diabetes. Recruitment to the study is now complete. Find out more at www.endia.org.au and Harry B.

Recruitment to the ENDIA Study has closed. The ENDIA (Environmental Determinants of Islet Autoimmunity) study is looking into what contributes to the development of Type 1 Diabetes in early childhood. Type 1 Diabetes in children is twice as common as it was 20 years ago. This is because our environment has changed and at-risk children are more likely to develop Type 1 Diabetes. If we can understand exactly what in the environment is harmful or protective, we can develop strategies to prevent Type 1 Diabetes. We believe that children are exposed to these environmental triggers very early in life, perhaps even before they are born. Accordingly, the ENDIA study has recruited 1511 participants across Australia from the pregnancy or up to 6 months of age that have a first-degree relative (i.e. baby's Mum, Dad or older sibling) with Type 1 Diabetes. ENDIA is an observational investigation and does not involve any study medications or treatments. Further information is available on the ENDIA website at www.endia.org.au. This research has been supported by JDRF Australia, JDRF-I, Australian Research Council Special Research Initiative in Type 1 Juvenile Diabetes and the Leona M. Helmsley Charitable Trust. Please note, comments and opinions made by others are not necessarily endorsed by the ENDIA Study Team. All content posted by the ENDIA Team has had ethical approval for public view. Thanks for your interest in finding the causes of Type 1 Diabetes!

02/04/2026

🦠 Gut bacteria bile acids may influence type 1 diabetes development

Researchers analyzed data and samples from 303 children (ages 3-36 months) and found gut bacteria create special bile acid molecules. These differ in children who develop diabetes autoantibodies compared to those who do not.

Why it matters: These molecules influence immune cell balance. Identifying this could lead to:

• Earlier T1D identification
• Dietary or probiotic interventions
• Better understanding of gut-immune connection

Read more at 🔗 https://www.nature.com/articles/s41467-025-56484-8

30/03/2026

Wave the flag. Fletcher has finished ENDIA study visits.

Fletcher, and his two siblings, have been involved in ENDIA since the . What a significant contribution to finding what causes .

Well done Mum! Jess has gone the extra mile (quite literally driving across NSW) to ensure ENDIA had all the samples and information possible from her three .

A massive thanks to Fletcher and the Trezona family for all their time and efforts.

27/03/2026

Leo, look how you’ve grown! From a bub before birth to nearly 10 years old, you have participated in the ENDIA Study regional program. We’ve loved watching you become a big boy from afar.

What a treat it was for regional nurse, Sarah, to be able to say farewell in person at your final ENDIA visit in Adelaide.

Thank you, and your mum, for all your help with our into the causes of . You’ve been amazing.

For further antibody testing, we recommend Type1Screen. This program is free for any family member of those diagnosed with and less intensive than the . For information and registration go to www.type1screen.org

24/03/2026

🏅 Josiah's Final ENDIA Visit: Mission Complete!

Look at that smile! Josiah received his gold medal at his last ENDIA Study visit, and we think he's pretty proud of himself—and he should be! 💛

From his very first visit as a baby to today, Josiah has been a . Every visit, every sample, every moment of participation has contributed to groundbreaking prevention .

To Josiah: Thank you for being such an amazing research champion! That gold medal is well-deserved. 🌟

To Josiah's family: Your dedication over the years has been incredible. Thank you for making a priority and for helping pave the way toward prevention for future generations.

We're going to miss seeing you at study visits, Josiah! 💙
________________________________________

The ENDIA Study follows children from as early as the pregnancy to understand early-life factors influencing type 1 diabetes development. www.endia.org.au

21/03/2026

🔬 Antibiotics Before Pregnancy May Affect Baby's Chance of Diabetes

Scientists reviewed 20 studies involving nearly 11,000 people with and found something unexpected: antibiotics during pregnancy had less influence than the year before conception!

Key finding: Certain (macrolides, sulfonamides, tetracyclines) taken before getting had a greater association with their future children developing .

Why: Antibiotics affect gut bacteria, which may influence the baby's immune development from the start.

What it means: If you're planning pregnancy, discuss antibiotic use with your doctor. More research is needed to confirm timing, other influences and specific types.

Read the article online at🔗 https://doi.org/10.3389/fendo.2026.1764522

18/03/2026

“Thank heavens” says Teddy, “No more ENDIA”.

Teddy looked overjoyed to say goodbye to the ENDIA Team at the Children’s Hospital at Westmead. Not because he didn’t love seeing Rose and Dr Maria; he really did! But he won’t miss the needles and swabs, p**p and wee. And fair enough! That’s enough of that, Teddy.

Thank you so much to you and your family for everything. We will put all your information to extra special good use to try to find what causes .

Teddy sure loved his gold medal and certificate. Almost worth it in the end 😊

There is continued follow up available for ENDIANs who wish it through Type1Screen: www.type1screen.org or the new Australian Diabetes Antibody Program... more about that soon.

15/03/2026

Eldest ENDIAN from , Isabelle, graduated last year.

Congratulations and well done, Isabelle. You can see how proud her parents were of her .

And what a wonderful big sister moment to see her little sister, Adeline, start her first day at school earlier this year.

Good luck this year Isabelle and Adeline for your first year of and primary school respectively.

All the best to all our ENDIANs embarking on a new school year. Be your best selves.

12/03/2026

🦠 Major ENDIA Discovery: Your Body's Response to Common Viruses May Hold the Key to Type 1 Diabetes

What we studied: We looked at how children's immune systems responded to (common childhood that nearly everyone gets).

We compared who developed early signs of with those who did not.

What your samples revealed: Children who developed showed different antibody patterns against these viruses—specifically:
• A consistent immune response pattern seen across all children
• Boys and girls showed different response patterns

The breakthrough: Almost every child gets these common viruses. Your participation helped us discover that it's not about catching the virus—it's about how each child's immune system responds to it that matters.

What this could lead to: ✨ Earlier ways to identify children at risk ✨ New approaches to ✨ Better understanding of why boys and girls have different chances of developing ✨ A completely new way of thinking about and autoimmunity.

Thank you, ENDIA families. Every sample, every visit, every bit of data you've shared over the years made this discovery possible. You're helping change how we understand type 1 diabetes.

🔗 Read the paper online: https://doi.org/10.2337/db25-0805

09/03/2026

Hello! My name is Addison. I am an ENDIAN. I am in the ENDIA Study because my mum has .

We want to see a world where type one becomes type none.

My mum helps me send all my p**p, wee, and other samples and information to ENDIA regional nurse, Sarah.

I live on the coast of . It’s very pretty.

Thanks for saying hello!

06/03/2026

The ENDIA Study team would like to acknowledge a remarkable career dedicated to improving the lives of people living with and at risk of type 1 diabetes — Professor Peter Colman. 🙏💙

Peter graduated with a degree in medicine from Monash University and trained in Diabetes and Endocrinology at the Royal Melbourne Hospital, going on to complete his MD studies in the autoimmunity of . What followed was a that has shaped the field in and around the world.

Since 1988, Peter has led the Endocrinology Laboratory, and since 1991 has served as Director of the Department of Diabetes and Endocrinology at the Royal Melbourne Hospital — more than three decades of extraordinary leadership.

His major research interests have centred on the prediction and prevention of , including his involvement with an international nasal vaccine trial and his co-leadership of the Australian and New Zealand TrialNet, Type1Screen and the ENDIA Study. He has been a driving force behind research into early-stage type 1 diabetes, giving families across Australia access to early risk detection and .

To the patients whose lives are better because of his care, to the researchers he mentored, and to the families who found hope through his work — this legacy is yours too.

Thank you, Peter. Enjoy every moment of a very well-earned . 🥂

Type 1 Diabetes TrialNet ANZ

03/03/2026

Evidence has shown 50% of pregnant women with type 1 diabetes experience glucose-related complications. Could automated insulin help?

Here we report on a study of 91 pregnant women with type 1 diabetes who used either:
- Closed-loop system (automated insulin delivery; AID), OR
- Standard care (pump/injections) + continuous glucose monitoring ( )

The results: Those using an AID experienced 65% time in range (TIR) compared to those using standard care of 50% TIR. That's a 15% improvement which has a flow on effect for mum and baby!

Reassuringly, serious "hypo" or "hyper" events were rare in both groups.

Why it matters:
Tight glucose control in is very important, but can be very hard to achieve. Closed-loop systems could help more women manage their diabetes without the constant mental load.

This is the largest study of its kind, and results strongly support closed-loop use in pregnancy with T1D 🌟

Read more online at: https://doi.org/10.1001/jama.2025.19578 (JAMA)

26/02/2026

🌎 New WHO Guidelines: Diabetes in Pregnancy 🌟

Reassuring news for mums-to-be living with type 1 diabetes! The new WHO guidelines are the first global roadmap to help women and babies thrive during .

What’s new?
✅ Care is built around the woman’s needs, values, and resources, aiming for a positive pregnancy experience
✅ Multidisciplinary specialist teams, like endocrinologists & maternal health experts, are now recommended for care
✅ Use of continuous glucose monitoring ( ) is advised for better blood glucose management, when available
✅ Early & serial ultrasounds, plus regular eye and kidney checks, are now part of routine diabetes pregnancy care
✅ Education is stepped up, with practical info about diet, activity, weight gain, and glycemic management tailored for pregnancy

How is this different?
🏥 Past guidelines focused mainly on gestational diabetes or general prenatal care. Now type 1, and other types of diabetes, has its own evidence-based, detailed global protocol
⚡ More personalised goals and monitoring, including CGM and regular specialist follow-up, improve both maternal and baby outcomes
👩‍⚕️ Ongoing review for long-term risks is stressed, not just insulin management

Why it matters? Accessible, specialist, and smarter care means safer pregnancies and healthier futures for mums and babies around the world.

Access the evidence-based guidelines at: https://www.who.int/publications/i/item/9789240117044

Address

Women's And Children's Hospital
Adelaide, SA
5006

Website

http://www.endia.org.au/

Alerts

Be the first to know and let us send you an email when ENDIA posts news and promotions. Your email address will not be used for any other purpose, and you can unsubscribe at any time.

Contact The Practice

Send a message to ENDIA:

Shortcuts

Want your practice to be the top-listed Clinic in Adelaide?