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Metanalyses, Gateway Circular Quay, Sydney/Office Level 36, Gateway 1 Macquarie Place, North Sydney (2025)

25/12/2025

🅜🅔🅣🅐 Published Today (December 24, 2025) - This meta-analysis evaluates the efficacy and safety of next-generation therapies for patients with advanced solid tumors, focusing on progression-free survival and adverse event profiles. TITLE: EFFICACY AND SAFETY OF NEXT-GENERATION THERAPIES IN ADVANCED SOLID TUMORS: A SYSTEMATIC REVIEW AND META-ANALYSIS

🅼 Link: https://doi.org/10.1038/s43856-025-01296-6

🅼 Key Findings:

• Next-generation targeted therapies demonstrated a statistically significant improvement in progression-free survival across various solid tumor types compared to standard-of-care treatments.

• The analysis revealed a higher objective response rate in patients receiving personalized medicine protocols guided by comprehensive genomic profiling versus conventional chemotherapy.

• Safety profiles remained manageable, though a higher incidence of grade 3/4 skin toxicity was observed in specific cohorts receiving epidermal growth factor receptor inhibitors.

• Subgroup analysis indicated that patients with specific biomarkers showed the most profound clinical benefit, suggesting the importance of early molecular screening in treatment.

• Long-term follow-up data suggested a trend toward improved overall survival, although further longitudinal studies are required to confirm the durability of these outcomes.

🅼 Clinical Relevance

This study underscores the shift toward precision oncology, providing clinicians with evidence-backed strategies for selecting targeted agents. It highlights the necessity of integrating genomic testing into routine practice to optimize patient outcomes and minimize unnecessary toxicity from broad-spectrum treatments, ultimately improving the quality of life for those with advanced cancers.

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24/12/2025

🅜🅔🅣🅐 Published Today (December 23, 2025) - This meta-analysis evaluates the efficacy of tranexamic acid (TXA) in reducing blood loss and transfusion requirements for patients undergoing major abdominal surgeries. TITLE: EFFICACY OF TRANEXAMIC ACID IN REDUCING BLOOD LOSS AND TRANSFUSION REQUIREMENTS IN MAJOR ABDOMINAL SURGERY: A SYSTEMATIC REVIEW AND META-ANALYSIS

🅼 Link: https://doi.org/10.1177/00031348251403589

🅼 Key Findings:

‘’ TXA significantly reduces the volume of intraoperative and postoperative blood loss compared to placebos in major abdominal procedures.

‘’ The administration of TXA is associated with a lower risk of requiring allogeneic blood transfusions, preserving patient blood volume.

‘’ No significant increase in the risk of thromboembolic events, such as deep vein thrombosis or pulmonary embolism, was found with TXA use.

‘’ The meta-analysis suggests that TXA is a safe and cost-effective pharmacological intervention for improving surgical outcomes.

‘’ Results indicate consistent benefits across various abdominal sub-specialties, including hepatobiliary and colorectal surgeries.

‘’ TXA treatment leads to higher postoperative hemoglobin levels, facilitating faster patient recovery and shorter hospital stays.

🅼 Clinical Relevance

TXA serves as a critical tool in blood management protocols for major abdominal surgery. By minimizing blood loss and the need for transfusions without increasing clotting risks, it enhances patient safety, reduces healthcare costs, and mitigates risks associated with blood transfusions. Surgeons should consider routine TXA use to optimize perioperative care and improve surgical recovery.

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23/12/2025

🅜🅔🅣🅐 Published Today December 22, 2025 - This meta-analysis evaluates the efficiency of older adult care in China and Japan, examining how resource allocation and institutional frameworks impact physical, mental, and social health outcomes. TITLE: OLDER ADULT CARE EFFICIENCY AND HEALTH OUTCOMES: A META-ANALYSIS OF THE CHINESE AND JAPANESE EXPERIENCES

🅼 Link: https://doi.org/10.3389/fpubh.2025.1604273

🅼 Key Findings:

• Enhanced efficiency in elderly care systems is a critical determinant of improved multidimensional health outcomes.

• Financial expenditure levels directly correlate with the quality and reach of care services provided to the elderly.

• Workforce size and professional training standards significantly influence the effectiveness of health interventions.

• Infrastructure standards in care facilities play a pivotal role in maintaining the physical safety of older patients.

• Subgroup analyses reveal significant disparities in care efficiency between urban and rural geographic settings.

• Policy initiatives, such as Japan's Long-Term Care Insurance, provide a framework for standardized care delivery.

• The study highlights that integrated care models improve social health by reducing isolation among the elderly.

• Efficient resource allocation is essential for nations facing rapid demographic aging and workforce shortages.

🅼 Clinical Relevance

Care efficiency is not merely an administrative metric but a clinical necessity. By optimizing workforce size and infrastructure, providers can significantly boost physical and mental recovery rates in older patients. Standardized care protocols, as seen in the Japanese model, ensure equitable health outcomes, providing a blueprint for healthcare systems to manage rapidly aging populations effectively.

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22/12/2025

🅜🅔🅣🅐 Published Today (December 21, 2025 in the Philippines; officially released online December 15, 2025) - This meta-analysis evaluates the efficacy of neoadjuvant chemotherapy (NAC) as a strategy for treatment de-escalation in HPV-positive oropharyngeal cancer to reduce long-term morbidity. TITLE: NEOADJUVANT CHEMOTHERAPY FOR OROPHARYNGEAL CANCER TREATMENT DE-ESCALATION: FROM HISTORICAL FAILURES TO CONTEMPORARY HPV-DRIVEN PARADIGMS

🅼 Link: https://doi.org/10.3390/cancers18010023

🅼 Key Findings:

• Analysis of modern HPV-stratified cohorts shows neoadjuvant chemotherapy (NAC) enables successful treatment de-escalation, reducing the need for aggressive radiation and extensive surgery.

• NAC followed by reduced-dose chemoradiotherapy (CRT) achieved high clinical complete response rates with overall survival exceeding 80–90% in favorable HPV-positive patient subgroups.

• De-escalated regimens guided by NAC response significantly lowered long-term feeding-tube dependence and improved swallowing function compared to standard-of-care high-dose treatments.

• Comparative data indicates NAC combined with surgery may decrease the incidence of distant metastases while sparing patients the severe toxicities of primary high-dose chemoradiation.

• Success in de-escalation is highly dependent on patient selection, specifically identifying low-risk HPV-driven profiles that respond robustly to induction systemic therapies.

🅼 Clinical Relevance

Clinicians can utilize NAC response as a biomarker to select candidates for reduced-intensity therapy. This approach mitigates debilitating side effects like dysphagia and xerostomia without compromising survival in HPV-positive oropharyngeal cancer. Integrating NAC into treatment algorithms represents a shift toward personalized, functional-preservation oncological care in the Philippines.

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21/12/2025

🅜🅔🅣🅐 Published Today (December 20, 2025) - This meta-analysis evaluates the efficacy of transcranial alternating current stimulation (tACS) as a non-invasive neuromodulation treatment for adults suffering from chronic insomnia. TITLE: EFFICACY OF TRANSCRANIAL ALTERNATING CURRENT STIMULATION FOR INSOMNIA: A GRADE-ASSESSED SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

🅼 Link: https://doi.org/10.1186/s41606-025-00163-6

🅼 Key Findings:

• tACS treatment led to a significant improvement in subjective sleep quality, with a mean reduction of 2.99 points in Pittsburgh Sleep Quality Index (PSQI) scores compared to sham groups.

• Sensitivity analysis further confirmed the positive impact on sleep quality, showing an even more pronounced mean difference of 3.79 points when outliers were removed from the study pool.

• While initial analysis of the Insomnia Severity Index (ISI) was not significant, sensitivity analysis revealed a substantial improvement in insomnia severity for those receiving tACS.

• There were no statistically significant differences found between tACS and sham stimulation regarding sleep onset latency, meaning it may not help patients fall asleep faster.

• Objective measures such as sleep efficiency and total sleep time did not show significant improvement, suggesting a gap between subjective perception and objective sleep data.

• The study found no significant impact on secondary psychological outcomes, including symptoms of depression or anxiety, as measured by standard clinical rating scales like HAMD.

🅼 Clinical Relevance

The study indicates that while tACS shows potential for improving how patients perceive their sleep quality, it lacks sufficient evidence to support broad clinical recommendations. High heterogeneity and low-certainty evidence mean clinicians should approach tACS as a supplemental rather than primary treatment until more large-scale, high-quality randomized controlled trials are conducted.

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20/12/2025

🅜🅔🅣🅐 Published Today (December 19, 2025) - This study evaluates an AI-driven digital health intervention for managing hypertension, focusing on its effectiveness in reducing blood pressure through personalized, data-backed patient monitoring. TITLE: EFFECTIVENESS OF AN AI-DRIVEN DIGITAL HEALTH INTERVENTION FOR HYPERTENSION MANAGEMENT: A RANDOMIZED CONTROLLED TRIAL

🅼 Link: https://doi.org/10.1038/s41746-025-02223-8

🅼 Key Findings:

• The AI intervention led to a statistically significant reduction in systolic blood pressure compared to standard care over a 6-month period.

• Participants using the digital platform showed higher adherence to prescribed antihypertensive medications and lifestyle modifications.

• Real-time data integration allowed for more precise, personalized adjustments to treatment plans by healthcare providers.

• The system effectively identified high-risk cardiovascular events earlier through continuous physiological monitoring and predictive modeling.

• Patient engagement levels remained high throughout the study, suggesting that AI-driven tools are user-friendly and sustainable for long-term use.

• Subgroup analysis indicated that the technology was equally effective across different age groups and baseline blood pressure levels.

🅼 Clinical Relevance

This research demonstrates that AI-driven digital tools can revolutionize chronic disease management. By providing real-time feedback and improving medication adherence, these interventions offer a scalable solution to reduce the global burden of hypertension and prevent long-term cardiovascular complications through more proactive, data-informed clinical decision-making.

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19/12/2025

🅜🅔🅣🅐 Published Today (December 19, 2025) - This meta-analysis evaluates the diagnostic accuracy and clinical utility of radiomics based on multiparametric MRI for predicting the histological grade of soft tissue sarcomas in patients. TITLE: DIAGNOSTIC PERFORMANCE OF MULTIPARAMETRIC MRI-BASED RADIOMICS IN PREDICTING THE HISTOLOGICAL GRADE OF SOFT TISSUE SARCOMAS: A SYSTEMATIC REVIEW AND META-ANALYSIS

🅼 Link: https://doi.org/10.1007/s10143-025-04000-3

🅼 Key Findings:

• Radiomics models derived from multiparametric MRI show high sensitivity and specificity in distinguishing between low-grade and high-grade soft tissue sarcomas (STS) across various studies.

• The pooled area under the curve (AUC) indicates robust discriminative power, suggesting that quantitative image analysis outperforms qualitative visual assessment by radiologists alone.

• Integration of multiple MRI sequences, such as T1-weighted, T2-weighted, and contrast-enhanced imaging, significantly improves the predictive accuracy of the radiomic signatures.

• Texture analysis and shape-based features are identified as the most reliable predictors of tumor aggressiveness and cellular proliferation in STS cases.

• The study highlights radiomics as a non-invasive "virtual biopsy" tool that can reduce the need for repetitive invasive procedures while providing a global view of tumor heterogeneity.

🅼 Clinical Relevance

Radiomics offers a non-invasive method to accurately grade soft tissue sarcomas, enabling personalized treatment planning. By predicting tumor aggressiveness before surgery, clinicians can better decide between limb-sparing surgery or more radical interventions. This reduces patient risk associated with invasive biopsies and ensures timely, targeted oncological care based on precise imaging data.

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18/12/2025

🅜🅔🅣🅐 Published Today (17 December 2025) - This meta-analysis evaluates the efficacy and safety of high-intensity interval training (HIIT) versus moderate-intensity continuous training (MICT) for patients with heart failure. TITLE: THE EFFECT OF HIGH-INTENSITY INTERVAL TRAINING VS. MODERATE-INTENSITY CONTINUOUS TRAINING IN PATIENTS WITH HEART FAILURE: A SYSTEMATIC REVIEW AND META-ANALYSIS

🅼 Link: https://doi.org/10.1038/s41598-025-31681-z

🅼 Key Findings:

• HIIT significantly improves peak oxygen consumption (VO2peak) compared to MICT, indicating superior cardiovascular fitness gains.

• Exercise duration and intensity are critical factors; HIIT protocols lasting over 12 weeks showed more pronounced improvements in aerobic capacity.

• Both HIIT and MICT are equally effective in improving left ventricular ejection fraction (LVEF), suggesting similar structural cardiac benefits.

• Quality of life scores improved across both groups, but HIIT participants often reported higher levels of physical functioning.

• Adverse events were low in both groups, confirming that HIIT is a safe alternative to traditional MICT for stable heart failure patients.

• Subgroup analysis suggests that HIIT may be particularly beneficial for younger patients or those with higher baseline fitness levels.

🅼 Clinical Relevance

HIIT provides a more time-efficient and effective method for improving aerobic capacity in heart failure patients compared to traditional MICT. Clinicians can safely prescribe HIIT to stable patients to maximize functional recovery and cardiovascular health. This evidence supports integrating varied intensity protocols into cardiac rehabilitation programs to enhance patient outcomes and adherence.

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17/12/2025

🅜🅔🅣🅐 Published Today December 16, 2025 - This meta-analysis evaluates the diagnostic accuracy of the prompt gamma-to-neutron ratio for real-time monitoring of proton beam range during cancer treatments, analyzing various detector systems.

TITLE: DIAGNOSTIC ACCURACY OF PROMPT GAMMA-TO-NEUTRON RATIO FOR PROTON BEAM RANGE VERIFICATION: A SYSTEMATIC REVIEW AND META-ANALYSIS

🅼 Link: https://doi.org/10.1038/s41598-025-28563-9

🅼 Key Findings:

• The study confirms that the prompt gamma-to-neutron ratio (PGNR) is a highly reliable metric for real-time range verification in proton therapy, showing high sensitivity across different studies.

• Meta-analysis results indicate a pooled sensitivity of 0.92 and specificity of 0.89, suggesting robust performance in detecting deviations in the proton beam’s Bragg peak position during delivery.

• The research highlights that secondary radiation—specifically prompt gammas and neutrons—provides a non-invasive signature that can be captured to ensure the beam stops precisely at the tumor.

• Various detector geometries were compared, with liquid scintillators and high-purity germanium detectors showing the most promising results for clinical integration and timing resolution.

• Heterogeneity among studies was noted due to varying phantom materials and beam energies, but the overall diagnostic odds ratio remains high, supporting the clinical potential of PGNR.

🅼 Clinical Relevance

This research is vital for improving the precision of proton therapy. By accurately verifying the beam range in real-time, clinicians can reduce margins around tumors, sparing healthy surrounding tissue and critical organs from unnecessary radiation. This minimizes side effects and improves the therapeutic index for cancer patients undergoing advanced radiotherapy treatments.

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16/12/2025

🅜🅔🅣🅐 Published Today (December 15, 2025) - A systematic review and meta-analysis assessing the impact of pharmacogenomic-guided dosing for fluoropyrimidine chemotherapy on toxicity rates and overall patient survival. TITLE: THE IMPACT OF PHARMACOGENOMIC-GUIDED DOSE ADJUSTMENTS ON FLUOROPYRIMIDINE-RELATED TOXICITY: A SYSTEMATIC REVIEW AND META-ANALYSIS

🅼 Link: 10.1177/10781552251405216

🅼 Key Findings:

• PGx testing significantly reduced the incidence of Grade 3/4 hematological toxicity by 45% (Pooled OR: 0.55; 95% CI, 0.41–0.74) compared to standard body surface area dosing. • Patients receiving PGx-guided lower initial doses demonstrated comparable overall survival rates to the standard dose group, confirming efficacy maintenance. • Preemptive pharmacogenomic screening for DPYD deficiency prevented severe adverse drug reactions (ADRs) in 8 out of 10 at-risk patients identified across the included trials. • The median time to treatment interruption due to toxicity was extended by an average of 14 days in the personalized dosing cohort, improving treatment continuity. • Implementation of PGx protocols showed a favorable pharmacoeconomic profile due to reduced hospitalization days and lower costs associated with toxicity management.

🅼 Clinical Relevance

Oncology pharmacists must champion DPYD pharmacogenomic testing before initiating fluoropyrimidine therapy (5-FU, capecitabine). Integrating PGx data allows for personalized dose reduction in high-risk patients, preventing life-threatening toxicities and supporting uninterrupted treatment schedules. This shift elevates the standard of pharmaceutical care in colorectal and breast cancer treatments.

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15/12/2025

🅜🅔🅣🅐 Published Today (December 14, 2025) - Comparing sleep disorder prevalence and outcomes in patients undergoing dialysis versus those who have received a renal transplant. TITLE: SLEEP DISORDERS IN RENAL PATIENTS: A COMPARATIVE ANALYSIS OF DIALYSIS AND POST-RENAL TRANSPLANT OUTCOMES

🅼 Link: https://doi.org/10.1038/s41598-025-28159-3

🅼 Key Findings:

Renal transplantation patients showed significantly lower odds of experiencing sleep disorders compared to matched patients with End-Stage Renal Disease (ESRD) on dialysis.

The study found significant improvements in Excessive Daytime Sleepiness (EDS) rates, decreasing from 44% in dialysis patients to 4% in the post-transplant group.

Risk of Obstructive Sleep Apnea (OSA) significantly decreased following renal transplantation, as assessed by EDS and specific questionnaires.

The prevalence of Restless Legs Syndrome (RLS) saw a significant reduction post-transplant, which is a common complication often associated with electrolyte imbalance in dialysis.

The overall quality of sleep was significantly improved in the group who had undergone renal transplantation.

Sleep disorders are confirmed to be an ongoing effect of ESRD, and renal transplantation highlights the benefits in improving sleep outcomes.

While improved, the association of OSA in kidney transplant recipients remains considerably high, ranging from 25% to 45%.

🅼 Clinical Relevance

This study offers strong evidence to counsel ESRD patients on the non-renal benefits of transplantation, specifically the significant improvement in sleep quality and a reduction in conditions like OSA, RLS, and EDS, which collectively enhance patient quality of life and potentially improve long-term graft survival.

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14/12/2025

🅜🅔🅣🅐 Published Today (December 13, 2025) - This systematic review assesses how AI-driven smartphone apps and wearables impact patient adherence, clinical outcomes, and data security in chronic disease management. TITLE: ARTIFICIAL INTELLIGENCE INTEGRATION IN MOBILE HEALTH: A SYSTEMATIC REVIEW AND META-ANALYSIS ON PATIENT ENGAGEMENT AND CLINICAL EFFICACY.

🅼 Link: https://doi.org/10.1038/s41523-025-00879-9

🅼 Key Findings:

AI-driven mHealth solutions significantly improve medication adherence (Odds Ratio: 1.75; 95% CI 1.45–2.08) compared to standard care, particularly for Type 2 Diabetes Mellitus.

Personalized feedback algorithms based on real-time physiological data enhance patient self-efficacy and lead to measurable reductions in HbA1c levels (-0.5% average) over a 6-month period.

Interoperability remains a key challenge, with only 35% of reviewed apps demonstrating seamless integration with Electronic Health Records (EHRs), limiting comprehensive data synthesis.

Wearable device data streams showed a high correlation with self-reported health metrics, validating their use as reliable proxy measures for monitoring disease progression outside of clinical settings.

Data privacy and security concerns were noted across 70% of studies, emphasizing the need for robust regulatory frameworks tailored to protect sensitive health data gathered via digital platforms.

The meta-analysis highlights the need for standardized reporting of mHealth intervention studies to allow for better comparison and aggregation of clinical trial results globally.

Engagement rates for mHealth apps drop sharply after 3 months, suggesting gamification and continuous content updates are critical for sustained user adherence and long-term benefit.

🅼 Clinical Relevance

Provides evidence-based guidance for clinicians to integrate vetted AI-mHealth tools into chronic disease management protocols. It underscores the potential to improve outcomes through highly personalized, continuous monitoring and timely intervention, shifting care from reactive to proactive, while also advising on crucial data security considerations for patient trust.

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Metanalyses

25/12/2025

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23/12/2025

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21/12/2025

20/12/2025

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18/12/2025

17/12/2025

16/12/2025

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14/12/2025

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