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Metanalyses, Gateway Circular Quay, Sydney/Office Level 36, Gateway 1 Macquarie Place, North Sydney (2025)

11/11/2025

⏱️ Finish Your Medical Research Hours in Just 48 Hours

Are you a busy doctor struggling to complete your research or CME requirements?

With Metanalyses, you don’t need weeks — we deliver high-quality, publication-ready meta-analyses and systematic reviews in as fast as 48 hours.

Our team of MDs and PhD researchers handle the heavy lifting — literature search, data extraction, analysis, and writing — so you can focus on your patients while earning your research hours quickly and credibly.

📚 Evidence-based.
⚡ Fast turnaround.
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Ready to complete your hours?
👉 Message us today or visit metanalyses.com to get started.

10/11/2025

Tirzepatide advantage!

Recent studies from The New England Journal of Medicine confirm that tirzepatide—the key compound in BH Slim Shots—drives sustained, clinically significant weight loss while lowering the risk of type 2 diabetes.
This isn’t a shortcut.

It’s evidence-based care: a therapy grounded in years of research, helping the body regulate both weight and blood sugar more efficiently.

For many, that means renewed energy, improved confidence, and measurable protection against long-term complications.
Check the published study here https://www.nejm.org/doi/full/10.1056/NEJMoa2410819... or at https://doi.org/10.1016/j.smrv.2025.102169

💡 Science works best when it’s paired with lifestyle integrity. Consult your physician to determine if this breakthrough fits your personal care plan.

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09/11/2025

🅜🅔🅣🅐 Published Today (November 3, 2025) - This meta-analysis of 83 studies investigates the link between post-discharge outpatient follow-up and 30-day hospital readmissions, identifying which patient groups benefit most. TITLE: OUTPATIENT FOLLOW-UP AND 30-DAY READMISSIONS: A SYSTEMATIC REVIEW AND META-ANALYSIS

🅼 Link: https://doi.org/10.1001/jamanetworkopen.2025.41272

🅼 Key Findings:

‘ This meta-analysis, including 76 studies in the final analysis, found that outpatient follow-up within 30 days was associated with a significant reduction in the risk of 30-day all-cause readmission (Relative Risk Ratio [RRR], 0.68).

‘ When analysis was restricted to studies with a low to moderate risk of bias, the association was less strong but remained significant (RRR, 0.78), indicating a 22% reduction in risk.

‘ The benefits were not universal and varied significantly by patient age and disease. The association was strongest in patients aged 65 years or older.

‘ For patients aged 65+, strong reductions in readmission risk were seen for those with heart failure (HF) (RRR, 0.65) and acute myocardial infarction (AMI) (RRR, 0.56).

‘ Patients aged 65+ with other conditions like stroke and chronic obstructive pulmonary disease (COPD) also showed a significant benefit from 30-day follow-up (RRR, 0.73).

‘ Early follow-up (within 7 or 14 days) also showed a significant reduction in readmissions, but this benefit was primarily seen in the 65+ age group with HF or AMI.

🅼 Clinical Relevance

These findings suggest that a targeted approach to post-discharge follow-up is more effective than a universal one. Healthcare systems should prioritize scheduling timely (within 30 days) follow-up for high-risk patients, particularly those aged 65 or older with diagnoses like heart failure, heart attack, stroke, and COPD, to optimize resources and reduce readmissions.

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09/11/2025

🅜🅔🅣🅐 Published Today (November 4, 2025) - A meta-analysis of 25 RCTs (40,731 participants) assessing if antiobesity medications (AOMs) and the weight loss they cause reduce the risk of obesity-associated cancers. TITLE: WEIGHT LOSS, OBESITY MEDICATION, AND RISK OF OBESITY-ASSOCIATED CANCER: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

🅼 Link: https://doi.org/10.1002/oby.70054

🅼 Key Findings:

This meta-analysis synthesized data from 25 randomized controlled trials (RCTs), including 40,731 participants, to evaluate the link between antiobesity medications (AOMs) and obesity-associated cancer risk.

When analyzing AOMs as a broad class, the study found no significant association with a reduced risk of overall obesity-related cancer compared to placebo (RR = 1.03, 95% CI: 0.78 to 1.37).

Similarly, the amount of weight lost did not correlate with risk reduction when all AOMs were grouped; every 5 kg of weight loss mediated by AOMs was not associated with a lower risk of overall obesity-related cancer (RR = 0.97).

A critical subgroup analysis, however, revealed that coagonists (e.g., tirzepatide, cotadutide, and cagrilintide) significantly reduced the risk of overall obesity-associated cancer (RR = 0.43, 95% CI: 0.19 to 0.97).

In this coagonist subgroup, every 5 kg of weight reduction was also marginally associated with a reduced cancer risk (RR = 0.79, 95% CI: 0.62 to 1.00), suggesting a protective effect specific to this class of medication.

🅼 Clinical Relevance

This analysis suggests that the cancer-protective benefits of weight loss medication may not apply to all AOMs equally. While a general link wasn't found, the positive signal from coagonists (like tirzepatide) is significant. It highlights the need for further research to differentiate between drug classes and to confirm if these specific medications can be used as a strategy for cancer prevention in patients with obesity.

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09/11/2025

🅜🅔🅣🅐 Published Today (November 6, 2025) - This meta-analysis validates using albuminuria (protein in urine) as a reliable predictor (surrogate endpoint) for kidney failure, which can speed up clinical trials for new CKD treatments. TITLE: A META-ANALYSIS OF ALBUMINURIA AS A SURROGATE ENDPOINT FOR KIDNEY FAILURE

🅼 Link: https://doi.org/10.1038/s41591-025-04057-z

🅼 Key Findings:

• Changes in urinary albumin-to-creatinine ratio (UACR) are strongly linked to the risk of kidney failure (end-stage kidney disease).

• Treatments that effectively lower albuminuria levels also significantly reduce the long-term risk of kidney failure progression.

• The meta-analysis confirms that the reduction in albuminuria is a consistent and reliable indicator of treatment benefit across various types of chronic kidney disease (CKD).

• Using albuminuria as a surrogate endpoint in clinical trials can lead to faster approval of new therapies by shortening trial duration and reducing sample size needs.

• The findings support the use of routine albuminuria monitoring in clinical practice to assess patient risk and guide therapeutic interventions more effectively.

🅼 Clinical Relevance

This study validates monitoring albuminuria as a key tool for clinicians. It allows for earlier assessment of treatment effectiveness and patient prognosis. For research, it confirms that trials for new CKD drugs can confidently use changes in albuminuria as a primary outcome, accelerating the development and approval of vital new therapies.

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05/11/2025

📣 🅜🅔🅣🅐 Published Today (November 5, 2025 — Philippines) - A meta-analysis evaluating whether adjunctive aspirin lowers stroke or death in tubercular meningitis patients by pooling randomized trials and exploring effects by aspirin dose. (200 chars)

TITLE: EFFECTS OF ASPIRIN ON STROKE AND MORTALITY IN TUBERCULAR MENINGITIS: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

🅼 Link: https://doi.org/10.3389/fmed.2025.1682144

🅼 Key Findings:

🔬 Adjunctive aspirin significantly reduced the risk of stroke in TB meningitis (pooled RR 0.56; 95% CI 0.33–0.95).
🔬 Low-dose aspirin showed superior protective effect versus high-dose in network meta-analysis.
🔬 Aspirin did not reduce all-cause mortality (RR 1.00; 95% CI 0.65–1.55).
🔬 No significant increase in bleeding events was observed with adjunctive aspirin.
🔬 Evidence was drawn from 5 RCTs (n=580); sensitivity analyses showed limited robustness for stroke outcome.
🔬 Overall GRADE certainty ranged from low to very low; heterogeneity and small trial sizes limit confidence.

🅼 Clinical Relevance

Adjunctive low-dose aspirin may lower stroke risk in tubercular meningitis without raising bleeding, but does not clearly reduce mortality; given low-quality evidence, clinicians should weigh potential stroke benefit vs uncertainty and await larger trials.

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05/11/2025

📣 🅜🅔🅣🅐 Published Today (November 5, 2025 — Philippines) - A systematic review/meta-analysis examining how AI tools predict and monitor psychosocial functioning in people with psychosis, summarizing model types, targets and performance.

TITLE: APPLICATION OF ARTIFICIAL INTELLIGENCE AND PSYCHOSOCIAL FUNCTIONING IN PSYCHOSIS: A SYSTEMATIC REVIEW AND META-ANALYSIS

🅼 Link: https://doi.org/10.3389/fpsyt.2025.1692177

🅼 Key Findings:

🔬 AI applied to psychosocial domains in psychosis (social, occupational, social cognition, QoL); 14 studies included showing varied targets and methods.

🔬 Supervised ML dominated; ensemble methods + feature selection common; NLP and DL less frequent.

🔬 Pooled discriminative performance moderate — AUC 0.70 (95% CI 0.63–0.76).

🔬 Prediction error pooled RMSE 8.15 (95% CI 7.32–8.98); clinical symptom predictors gave lower RMSE (≈7.1).

🔬 Social cognition predictions performed better (AUC ≈0.77) than broader psychosocial outcomes.

🔬 Considerable heterogeneity driven by small samples, variable outcome measures, and inconsistent reporting.

🔬 Ethical, data-quality, and implementation concerns limit clinical readiness; AI best seen as adjunct to clinicians.

🅼 Clinical Relevance

AI shows promise for early detection, continuous monitoring, and tailoring psychosocial interventions in psychosis by identifying patients at risk of functional decline and tracking recovery trajectories; however, methodological variability and ethical concerns mean clinical deployment should be cautious and complementary to clinician judgment.

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28/10/2025

📣 🅜🅔🅣🅐 Published Today (October 28, 2025 — A systematic review/meta-analysis assessing best Tai Chi course & frequency for knee osteoarthritis patients; summarizes 13 RCTs and pooled effects on pain, stiffness, function.)
TITLE: THE OPTIMAL COURSE AND FREQUENCY OF TAI CHI FOR KNEE OSTEOARTHRITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

🅼 Link: https://doi.org/10.3389/fpubh.2025.1661674

🅼 Key Findings:
🔬 Tai Chi reduced pain (WOMAC pain SMD = -0.41; VAS pain SMD = -0.33), showing small-to-moderate clinically meaningful effects across pooled trials.
Frontiers

🔬 Tai Chi reduced stiffness (WOMAC stiffness SMD = -0.27) and improved physical function (WOMAC function SMD = -0.52) in pooled analyses.
Frontiers

🔬 Tai Chi improved overall physical health measured by SF-36 PCS (SMD = 0.47); mental health effects (SF-36 MCS) were reported but less consistent.
Frontiers

🔬 The review included 13 RCTs totaling 701 participants; interventions and frequencies varied, so explicit “one best dose” remains tentative.
Frontiers

🔬 Methods: comprehensive search to Aug 30, 2025; outcomes pooled as SMDs with GRADE assessment for certainty reported.
Frontiers

🅼 Clinical Relevance

Tai Chi is a safe, nonpharmacologic option that moderately reduces pain and stiffness and improves function in knee OA patients; it can be recommended as part of multimodal conservative care while tailoring frequency/duration to patient ability and preference.
Frontiers

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28/10/2025

📣 🅜🅔🅣🅐 Published Today (October 28, 2025, Philippines) - A meta-analysis of randomized trials examining whether acupuncture changes autonomic nervous system markers (HRV parameters) and whether it is safe for patients.
TITLE: CLINICAL EFFICACY AND SAFETY OF ACUPUNCTURE IN MODULATING AUTONOMIC NERVOUS FUNCTION: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

🅼 Link: https://doi.org/10.3389/fnins.2025.1694110

🅼 Key Findings:

🔬 Acupuncture showed a significant improvement in SDNN (an overall HRV measure) across pooled trials, suggesting modest enhancement of autonomic balance.
🔬 LF and HF measures hinted at changes in sympathetic and parasympathetic tone, but effect estimates were uncertain and inconsistent.
🔬 Ten RCTs with 744 patients were included — sample sizes were small to moderate, limiting precision.
🔬 Heterogeneity existed across trials (methods, acupoints, stimulation parameters), reducing confidence in pooled estimates.
🔬 Risk of bias and methodological limitations (blinding, allocation reporting) were present in several studies.
🔬 Adverse events were uncommon and generally mild; no serious safety signals were reported.
🔬 Authors conclude acupuncture may modestly improve ANS function (notably SDNN) but stronger, higher-quality trials are needed.

🅼 Clinical Relevance

Acupuncture may offer a safe, adjunctive approach to mildly improve autonomic balance (e.g., SDNN increase) in select patients; however, heterogeneity and study quality limit strong clinical recommendations. Larger, standardized RCTs are needed to confirm patient-level benefits.

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28/10/2025

📣 🅜🅔🅣🅐 Published Today (October 28, 2025) - This meta-analysis evaluates GPT models’ diagnostic accuracy in radiology, comparing versions, input types, and impact of clinical context on outcomes.
TITLE: A SYSTEMATIC REVIEW AND META-ANALYSIS OF GPT-BASED DIFFERENTIAL DIAGNOSTIC ACCURACY IN RADIOLOGICAL CASES: 2023–2025

🅼 Link: https://doi.org/10.3389/fradi.2025.1670517

🅼 Key Findings:
🔬 GPT-4T showed highest differential diagnostic accuracy (72%, median 82.32%), outperforming GPT-4, GPT-4o, and GPT-3.5.
🔬 Textual inputs had higher accuracy (GPT-4: 56.46%, median 58.23%) compared to visual inputs (GPT-4V: 42.32%, median 41.41%).
🔬 Inclusion of clinical history improved accuracy (OR = 1.27, p = .001) in adjusted models.
🔬 Private datasets achieved significantly higher accuracy (86.51%, median 94.00%) than public datasets (47.62%, median 46.45%).
🔬 Accuracy improved in newer GPT models over time; GPT-3.5 showed declining performance.
🔬 Study analyzed 8,852 radiology cases across multiple subspecialties, confirming consistent trends in differential diagnosis capability.
🔬 Generalized linear mixed-effects model identified predictors influencing model performance including model version, input type, and dataset source.

🅼 Clinical Relevance
GPT-4T and newer GPT models can enhance radiological diagnostic workflows, particularly when combined with textual input and private datasets, improving efficiency and accuracy in clinical decision-making.

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28/10/2025

📣 🅜🅔🅣🅐 Published Today (October 28, 2025) - This meta-analysis evaluates baloxavir vs oseltamivir in children, assessing effectiveness and safety for influenza treatment.
TITLE: COMPARISON OF THE EFFICACY AND SAFETY OF BALOXAVIR VERSUS OSELTAMIVIR IN PEDIATRIC PATIENTS WITH INFLUENZA: A META-ANALYSIS

🅼 Link: https://doi.org/10.3389/fmicb.2025.1672925

🅼 Key Findings:
🔬 Baloxavir significantly reduced the time to symptom alleviation compared with oseltamivir.
🔬 Both drugs were similarly effective in viral load reduction in pediatric patients.
🔬 Adverse event rates were lower for baloxavir, indicating a favorable safety profile.
🔬 Baloxavir showed better compliance due to single-dose administration.
🔬 Oseltamivir required multiple daily doses, potentially impacting adherence.
🔬 No significant differences were observed in hospitalization rates.
🔬 Baloxavir was well-tolerated across different influenza strains, including A and B.
🔬 Subgroup analyses suggested faster recovery in children under 12 years with baloxavir.
🔬 Overall, baloxavir demonstrated slightly superior efficacy in reducing fever duration.

🅼 Clinical Relevance
Baloxavir offers a convenient single-dose alternative to oseltamivir, providing effective symptom relief, improved adherence, and a safer side-effect profile in children with influenza.

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28/10/2025

📣 🅜🅔🅣🅐 Published Today (October 28, 2025, Philippines) - This network meta-analysis evaluates oral commercial Chinese polyherbal preparations combined with standard anti-TB drugs, assessing efficacy and immune outcomes across randomized trials. (200 chars)

TITLE: ORAL COMMERCIAL CHINESE POLYHERBAL PREPARATIONS COMBINED WITH CONVENTIONAL BIOMEDICINE FOR PULMONARY TUBERCULOSIS: NETWORK META-ANALYSIS

🅼 Link: https://doi.org/10.3389/fphar.2025.1588586

🅼 Key Findings:

🔬 A network meta-analysis of 100 RCTs (12,747 participants) compared 12 oral commercial Chinese polyherbal preparations (CCPP) as adjuncts to standard anti-TB therapy.

🔬 Overall, CCPP + biomedicine outperformed biomedicine alone across multiple endpoints including clinical response, sputum negative conversion, lesion absorption, cavity absorption, and T-cell improvements.

🔬 FeiJieHe Pill + standard therapy ranked highest for clinical response (OR 8.43; 95% CI 1.79–39.69) and cavity absorption (OR 5.11; 95% CI 2.04–12.85).

🔬 KangLao Pill + standard therapy gave the largest benefit for sputum negative conversion (OR 11.55; 95% CI 3.04–43.93).

🔬 Bu Jin Tablet + standard therapy showed strongest lesion absorption (OR 7.46; 95% CI 3.32–16.75).

🔬 JieHe Pill combined therapy produced the greatest improvements in CD3+ and CD4+ T-lymphocyte recovery.

🔬 Safety signals were reported variably; many trials were single-center and of heterogeneous quality, so effect estimates should be interpreted with caution.

🔬 Authors call for multicenter, large-sample, high-quality RCTs to confirm optimal CCPP choices and long-term safety.

🅼 Clinical Relevance

Adjunctive oral CCPP may enhance standard anti-TB outcomes (faster sputum conversion, better radiologic lesion and cavity resolution, and immune recovery). Findings suggest potential value in integrated care but require confirmation by rigorous, multicenter trials before routine adoption into global TB guidelines. (≈ 370 chars)

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