17/02/2026
I’ll bet my favourite kitty that you’ve never had leptin tested 👀
It’s rarely included in routine pathology panels, even in many fertility investigations, yet it plays a central role in whether the brain initiates ovulation at all.
When a high-functioning woman comes to see me for cycle changes or fertility support, I’m often thinking about energy signalling upstream. Not just ovarian hormones.
Leptin is produced by fat cells and travels to the hypothalamus, where it helps inform the brain whether there’s enough overall stability to proceed with reproduction. And that stability isn’t just about food intake. It reflects nervous system load, sleep patterns, circadian rhythm, and sustained output.
If someone is running on go-go energy, sleeping inconsistently, managing constant cognitive demand, and living in a low-grade stress state, leptin signalling can shift, even when standard hormone panels look kind of normal.
Ovulation is a brain decision.
Leptin is part of that conversation.
It’s not routinely tested. But in the right clinical context, it can change how the whole picture is interpreted ❤️🔥