02/12/2025
What is the Endocannabinoid system (ECS) in humans?
Cannabinoids both endogenous and exogenous interact with receptors already present in the human body. The receptors are CB1 (brain and nervous system)and CB2 (immune system and peripheral tissues).
Body made or endogenous cannabinoids include Anandamide and 2-AG (2-arachidonolglycerol). Plant cannabinoids mimic or modulate these natural signaling molecules. CB1 receptors are concentrated in the hippocampus (memory), basal ganglia (movement), cortex (thinking), cerebellum (co-ordination), amygdala (emotion and fear).
The cannabis genus and its main species, indica and sativa have a rich mix of natural compounds, mainly cannabinoids, terpenes, flavonoids which are produced in the plant’s resin glands called trichomes.
The cannabinoids include
THC (tetrahydrocannabinol) the main psychoactive compound, binds strongly to CB1 receptors in the brain, responsible for euphoria, altered perception, appetite stimulation
CBD (cannabidiol) non-psychoactive, modulates CB1/CB2 receptors indirectly, can reduce inflammation, anxiety and counteract some THC effects,
Also contains CBN, CBG, CBC
Terpenes are the aromatic molecules that contribute to scent, taste and effects. These include myrcene, limonene, pinene, linalool and caryophyllene.
Flavonoids such as cannaflavins can be anti-inflammatory and MAST cell stabilisers.
Human use of cannabis goes back thousands of years. Its popularity has never waned and now we see in many countries around the world the decriminalisation and legalisation as a medicine in many different forms. Talk to allopathic medical practitioner is to see if it could be helpful for you. At this stage in Australia professional herbalists are unable to prescribe any cannabis product. H**p products are not the same as medicinal cannabis.