06/02/2026
Louisa Nicola on Early Brain Health, Alzheimer’s Prevention and Lifestyle Factors | The Diary Of A CEO Podcast
This deeply informative episode features neurophysiologist Louisa Nicola discussing how cognitive decline begins silently decades before symptoms appear, why lifestyle matters for brain health, and what science-backed strategies can help protect cognition over the long term.
🧠 Silent Early Onset – Nicola explains that neurodegenerative processes associated with Alzheimer’s begin as early as your 30s or 40s, long before memory problems appear later in life.
🏃 Exercise and Brain Resilience – Physical activity, including both resistance training and cardiovascular exercise, stimulates growth factors like BDNF and myokines, supporting healthy brain structure and reducing risk factors for cognitive decline.
🥗 Lifestyle Factors Matter – Sleep quality, diet, movement and metabolic health influence how the brain ages. Poor sleep and sedentary behaviour worsen risk, whereas intentional habits help protect cognitive function.
⚖️ Women’s Risk and Hormonal Shifts – Nicola highlights that women are disproportionately affected by Alzheimer’s and that midlife hormonal changes can impact brain energy and susceptibility.
🧬 Prevention Over Inevitability – The episode reframes cognitive decline as largely preventable through lifestyle, challenging the assumption that Alzheimer’s is an unavoidable part of ageing.
“Brain health doesn’t begin in old age, it begins decades earlier, and what we choose today shapes who we remain tomorrow.”
Why this matters
For anyone curious about ageing well, protecting cognitive function, or understanding how lifestyle impacts long-term brain health, this episode offers practical science-based insights and actionable habits that go beyond surface-level advice.
🎧 Watch or listen to the full episode here: https://www.youtube.com/watch?v=0t_DD5568RA