15/04/2026
ADHD isn’t just behavioural.
It’s neurochemical.
If you’ve been diagnosed with ADHD - or suspect you have it - one enzyme matters more than most:
COMT
COMT controls how quickly your brain breaks down dopamine, especially in the prefrontal cortex - the area responsible for:
• focus
• motivation
• planning
• impulse control
• emotional regulation
Here’s where it gets interesting 👇
Too little dopamine → poor focus, low drive
Too much dopamine → anxiety, overthinking, irritability
COMT determines how fast dopamine is cleared.
And your genetics influence this directly.
Some people clear dopamine too quickly.
Others hold onto it longer.
Neither is “good” or “bad”.
But it changes how your brain functions under stress, pressure and stimulation.
This is why ADHD treatment isn’t one-size-fits-all.
Different people respond very differently to the same strategies or medications.
The shift is this:
Stop asking
“Why can’t I focus?”
Start asking
“How does my brain regulate dopamine?”
Because once you understand that, you can start to personalise your approach.