When Weight Matters

23/01/2026

23/01/2026

A new study published in Science sheds light on a long-standing question: how obesity leads to chronic, uncontrolled inflammation - a key driver of conditions like type 2 diabetes and fatty liver disease.

Researchers found that in people living with obesity, immune cells show overactivation of an inflammatory pathway (called NLRP3). This appears to be triggered by damage inside the cell’s mitochondria - not infection, but a biological cascade involving disrupted DNA processing.

Why this matters:
This research reinforces what many have long known:
➡️ Obesity is not a matter of willpower or personal failure.
➡️ It is a complex, biological condition with underlying molecular mechanisms.
➡️ Understanding these pathways opens the door to more targeted, compassionate, evidence-based treatments.

As science continues to uncover the biology of obesity, it strengthens the case for moving beyond blame, and toward care.

https://ow.ly/REPN50Y1iP5

22/01/2026

20/01/2026

https://conscienhealth.org/2026/01/19/the-incomprehensibility-of-a-chronic-disease/

The incomprehensibility of chronic disease often gets in the way of dealing with obesity. It lead us to fall back on simplistic narratives.

13/01/2026

Dr. Sean Wharton, internal medicine specialist and obesity medicine researcher, reminds us that weight regain isn’t a personal failure - it’s biology.

After weight loss, the hormones that regulate hunger and body weight become stronger. When treatment stops, those signals return. That’s not weakness. That’s the body doing what it’s designed to do.

Comparing people who pursue lifestyle changes alone with those who seek medical support misses the point - these are often different journeys, especially for people who have already tried everything else.

But perhaps the most powerful message wasn’t scientific. It was human.

✨ You are not defined by a number.
✨ Your worth is not measured by your weight.
✨ Caring for your health is about protecting your future - not fitting into a dress.

“Be kind to yourself.”
It may be the most important prescription of all.

10/01/2026

https://conscienhealth.org/2026/01/09/the-onslaught-of-telehealth-weight-loss-and-obesity-care/

Have you noticed the onslaught of advertising for telehealth weight loss and obesity care? Here are some thoughts on how to sort it out.

05/01/2026

In Obesity Science & Practice, James Kite et al make it clear that researchers and clinicians in cannot be neutral about and . They can either perpetuate it or challenge it.
https://conscienhealth.org/2026/01/05/making-a-choice-perpetuate-or-challenge-obesity-stigma/

16/12/2025

Criminals are moving in on the opportunity for bogus . Why? Health systems conspire to deny access to safe and effective medicines for the sake of their own bottom lines. Money talks and patients suffer all around.
HT: The Times and The Sunday Times
https://conscienhealth.org/2025/12/profiteering-and-the-criminal-trade-in-bogus-obesity-medicines/

11/12/2025

Our friend Ximena Ramos Salas has a guest post on ConscienHealth today that you must not miss. All about the need for clarity about the bright line between and . https://conscienhealth.org/2025/12/a-bright-line-between-health-promotion-and-obesity-prevention/

11/12/2025

This is well worth reading :

Eating More Calories Increases Weight (In Some People – Sometimes – Maybe) Friday, February 18, 2011 Simple but Completely Wrong Depiction of Energy Balance According to the laws of physics when [calories in] exceed [calories out] people gain weight. Unfortunately, when you actually deal with pe...