10/10/2025
Obesity isn’t simply a matter of willpower or lifestyle — it’s a complex biological condition shaped by genetics, hormones, environment, and behaviour.
Emerging research shows that epigenetic mechanisms — changes in how our genes are expressed without altering our DNA, play a powerful role in how obesity develops, progresses, and even passes between generations.
These changes, including DNA methylation, histone modification, and chromatin accessibility, can influence:
•How our bodies store and burn fat
•Our risk for insulin resistance, type 2 diabetes, and metabolic syndrome
•Why some individuals remain metabolically healthy while others develop complications
The good news? Epigenetic changes are dynamic and reversible, opening doors to precision treatments and early detection through epigenetic biomarkers in blood.
As science advances, understanding the link between metabolism and epigenetics will be key to developing compassionate, evidence-based obesity care that looks beyond the scale.