02/03/2026
One of the greatest challenges in keloid treatment is recurrence.
Surgical removal alone is associated with very high recurrence rates, with studies reporting re-formation in up to 100% of cases, in some instances, regrowth that exceeds the size of the original scar.
This high recurrence rate makes combination and vigorous adjuvant approaches essential.
When radiotherapy is used immediately following surgical excision, recurrence rates can be significantly reduced in appropriately selected patients, particularly when delivered within a defined postoperative window.
Radiotherapy acts by modulating fibroblast activity and collagen production, targeting the biological processes that drive keloid formation, interrupting the cycle that leads to scar reformation.
Contemporary radiotherapy techniques allow for precise delivery of radiation to the surgical site, limiting exposure to surrounding healthy tissue.
Treatment is typically administered shortly after surgical removal, during a biologically active phase of wound healing. Exact timing and dosing are tailored to the individual case.
Radiotherapy is not a first-line treatment for all keloids and is generally reserved for specific situations, such as recurrent keloids, large or aggressive lesions requiring surgical removal, or cases where other adjuvant therapies have been insufficient.
Importantly, radiotherapy is usually considered as part of a broader, multimodal management plan, alongside other adjuvant strategies aimed at reducing recurrence and supporting long-term scar stability.
Understanding the role of radiotherapy within comprehensive keloid management allows patients and clinicians to make informed, individualised decisions, balancing potential benefits with risks and considering alternative or complementary adjuvant options as part of an overall treatment strategy.