25/11/2025
MTHFR gets a LOT of attention in the fertility space and this information just scratches the surface of the basics. There’s so much more to consider, including your homocysteine levels, overall methylation capacity, nutrient status and your unique fertility picture.
So what is MTHFR?
The MTHFR gene provides instructions for making an enzyme that activates folate into its usable form (5-MTHF).
Some people carry natural variations, often called polymorphisms or mutations, that make this enzyme work a little (or a lot) slower.
This can influence how well the body methylates, processes folate, regulates hormones, supports egg & foetal development and prepares for early pregnancy.
The two most common MTHFR gene variants are:
• C677T
• A1298C
Many women carry one or both of these and for some, they can influence how effectively the body activates folate.
Here’s what we do know:
👉 MTHFR variants are common
👉 Not everyone with a variant experiences issues
👉 But reduced MTHFR activity can influence folate activation, hormone balance, implantation and early foetal development
And this is why the type of folate you take matters.
Women with MTHFR variants often respond better to active folate forms like 5-MTHF or folinic acid, not folic acid which relies heavily on MTHFR for activation. But it's important to know which type is best for your individual needs.
Testing isn’t essential for everyone, but it can be helpful if you’ve experienced:
• Early losses
• Unexplained fertility struggles
• Elevated homocysteine
• Fatigue or low mood
• A family history of MTHFR SNPs or neural tube defects
✨ If you want clarity on your own folate needs, fertility or MTHFR status, my 1:1 care helps you understand exactly what your body needs without the overwhelm. Book your FREE discovery call to ask me how my services can support you ✨