25/11/2025
Seasonal allergies affect millions every year, and the conventional approach is straightforward: take antihistamines, maybe add a nasal spray, and wait for the season to pass. But if you're increasingly miserable despite these medications, and this past season has got you wondering what you can do for next year, this post is for you.
Your immune system's reactivity to allergens is significantly influenced by your baseline inflammatory state, and for women in perimenopause/menopause, hormonal shifts to the gut can further impact histamine responses.
When your body is already dealing with chronic low-grade inflammation from poor sleep, stress, gut issues, or processed foods, your threshold for reacting to allergens drops:
👉🏽Emerging research reveals important connections between gut health & allergic responses. Studies show that people with more diverse gut microbiomes and healthy populations of beneficial bacteria tend to have less severe allergic reactions.
👉🏽Gut dysbiosis - often caused by antibiotics, chronic stress, or low fibre intake, is associated with increased allergic sensitivity. The gut bacteria produce metabolites that help regulate immune function throughout your body, including how aggressively you react to environmental triggers.
👉🏽Certain nutritional factors influence mast cell stability; the immune cells that release histamine during allergic reactions.
Constant release of inflammatory mediators disrupts sleep, impairs cognition, and increases fatigue. Poor sleep then makes your immune system more reactive the next day, creating a feedback loop where allergies disrupt sleep, and poor sleep worsens allergies... 🫣
The functional approach considers these interconnected factors:
👉🏽Support gut health through adequate fibre and probiotic foods.
👉🏽Ensure optimal vitamin D (and b vitamins if methylation is a priority) levels through testing.
👉🏽Include anti-inflammatory foods rich in omega-3s.
👉🏽Prioritise sleep and stress management.
When you address underlying drivers of immune hyperreactivity, allergies often become more manageable without increasingly aggressive medication.
PMID: 22266772
PMID: 35233003
PMID: 32971520