29/08/2022
Les bienfaits de l'activité physique sur l'organisme. Il est toujours bon de le rappeler.
Take your Exerkines! 💊💊💊💊 🏋♂🚴♂🏋🏃♂
https://www.nature.com/articles/s41574-022-00641-2
👉 The health benefits of exercise are well-recognized and are observed across multiple organ systems. These beneficial effects enhance overall resilience, health span and longevity.
👉 The molecular mechanisms that underlie the beneficial effects of exercise, however, remain poorly understood. Since the discovery in 2000 that muscle contraction releases IL-6 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2270169/), the number of exercise-associated signalling molecules that have been identified has multiplied.
👉 Exerkines are defined as signalling moieties released in response to acute and/or chronic exercise, which exert their effects through endocrine, paracrine and/or autocrine pathways.
👉 A multitude of organs, cells and tissues release these factors, including skeletal muscle (myokines), the heart (cardiokines), liver (hepatokines), white adipose tissue (adipokines), brown adipose tissue (baptokines) and neurons (neurokines) with local autocrine effects (affecting the cell of origin) and paracrine effects (affecting adjacent cells) . (s. Figure a)
👉 Exerkines have potential roles in improving cardiovascular, metabolic, immune and neurological health. As such, exerkines have potential for the treatment of cardio-vascular disease, type 2 diabetes mellitus and obesity, and possibly in the facilitation of healthy ageing. (Figure b)
🖼 Figure: The systemic effects of exercise. a | Organs and tissues that can serve as source of exerkines and that are directly affected by exercise. b | Exercise results in profound health benefits, including reductions in the presence or severity of certain diseases, as well as increases in healthspan, longevity and resilience. T2DM, type 2 diabetes mellitus.