06/11/2025
Post-operative delirium (POD) in older individuals is an acute, fluctuating disturbance in attention and cognition that often develops shortly after surgery and anesthesia. It's characterized by problems with focus, awareness, and thinking, which can range from hypoactive (quiet and withdrawn) to hyperactive (agitated and confused) states, significantly increasing morbidity and mortality in this population. POD is quite common, affecting an estimated 10% to 50% of older adults following major surgery, depending on the patient's health status, the complexity of the procedure, and the specific assessment methods used.
A randomized controlled clinical trial evaluated the effects of inhaling peppermint EO on POD in older adults after surgery. The peppermint group inhaled one drop from a cotton pad soaked with 2 mL of 2% peppermint EO that was placed near his or her nose for 10 minutes the night before the surgery, prior to receiving anesthesia, and while in the post-anesthesia care unit. The control group inhaled saline from a cotton pad in the same manner. The peppermint EO group experienced significantly lower POD incidence within the three days following surgery. The peppermint group also reported reduced pain and anxiety scores as a side benefit. These findings suggest peppermint EO inhalation is an effective way to reduce POD and improve surgical outcomes in older adults.
https://www.sciencedirect.com/science/article/pii/S1550830725001636