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NeuroScience News Bahia

Esta página dispoe informações sobre tema e idéias importantes para o seu conhecimento e bem estar, focando no melhor desempenho via de regra. Ciência é saúde!

Postagens sobre os mais avançados tratamentos e medicamentos na área da saude mental e física.

08/12/2025

(tradução)
2025 Westlake - Simpósio Online Conjunto Científico

Simpósio #10: Instabilidade genômica no envelhecimento e no câncer

A instabilidade do genoma, a acumulação progressiva de danos no ADN e de erros cromossómicos, é um dos mecanismos biológicos fundamentais que impulsionam os dois desafios de saúde mais profundos da humanidade: o envelhecimento e o cancro. Este simpósio destaca vários avanços fundamentais nesta interface crítica para explorar a interface dinâmica entre integridade genômica e doença. Os participantes obterão insights sobre estratégias emergentes para melhorar o reparo do DNA e retardar o envelhecimento celular, examinar a dependência pouco explorada dos cânceres em anormalidades cromossômicas específicas e descobrir como a instabilidade genômica persistente pode reprogramar o microambiente tumoral para permitir a evasão imunológica e a metástase. Junte-se a nós para um diálogo prospectivo sobre como a decodificação dos princípios da estabilidade do genoma pode ser pioneira em novos caminhos terapêuticos para ampliar a expectativa de saúde e enfrentar o câncer.

Data/Hora
20h às 22h, segunda-feira, 15 de dezembro de 2025 (Leste dos EUA)
9h às 11h, terça-feira, 16 de dezembro de 2025 (China)

Anfitriões
Bryan Ray, Ciência/AAAS
Hongtao Yu, Universidade Westlake/Laboratório Westlake
(Original)
2025 Westlake - Science Joint Online Symposium

Symposium #10: Genomic Instability in Aging and Cancer

Genome instability, the progressive accumulation of DNA damage and chromosomal errors, is one of the fundamental biological mechanisms driving humanity’s two most profound health challenges: aging and cancer. This symposium highlights several pivotal advances at this critical interface to explore the dynamic interface between genomic integrity and disease. Attendees will gain insights into emerging strategies to enhance DNA repair and delay cellular aging, examine the underexplored dependency of cancers on specific chromosomal abnormalities, and discover how persistent genomic instability can reprogram the tumor microenvironment to enable immune evasion and metastasis. Join us for a forward-looking dialogue on how decoding the principles of genome stability can pioneer new therapeutic pathways for extending healthspan and confronting cancer.

Date/Time
8-10 pm, Monday, December 15, 2025 (Eastern US)
9-11 am, Tuesday, December 16, 2025 (China)

Hosts
Bryan Ray, Science/AAAS
Hongtao Yu, Westlake University/ Westlake Laboratory
Speskers / Oradores

*Jun Li

Ph.D.·Westlake Laboratory/Westlake University

*Jason Sheltzer

Ph.D.·Stanford University

*Jessica Tyler

Ph.D.·Weill Cornell Medicine

Genome instability—the progressive accumulation of mutations and chromosomal errors—is a fundamental biological mechanism driving two of humanity’s most profound health challenges: aging and cancer. This online symposium will explore the dynamic interface between genomic integrity and disease,...

21/11/2025

B cells targeting parasites capture spatially linked antigens to secure T cell help
Xin Gao
https://orcid.org/0000-0002-5927-2241, Hayley A. McNamara https://orcid.org/0000-0001-6347-6215, [...] , and Ian A. Cockburn
https://orcid.org/0000-0001-8220-9294+17 authors Authors Info & Affiliations
🌱🙂‍↕️
Science Immunology
🦠🧫
7 Nov 2025

Antigen location orchestrates T cell–B cell collaboration in response to large pathogens.

20/11/2025

CareersWorking Life

How I recovered from a collaboration gone wrong
6 Nov 20252:00 PM ETBy Sorin M. S. Krammer

After learning “how quickly ‘we’ can turn wicked,” this researcher reshaped his approach

20/11/2025

As an international scholar, my academic dreams belong to my family, too..
☝️🧐📈

When this scientist’s father fell ill far away, he had to reconsider how best to honor his family’s sacrifice

20/11/2025

Targeting the origins of multiple myeloma along hematopoietic stem cell lymphoid lineage differentiation

Jiaojiao Guo
https://orcid.org/0009-0008-5908-492X, Yaru Li
https://orcid.org/0000-0001-5711-6416, [...] , and Wen Zhou
https://orcid.org/0000-0003-0834-9306+25 authors Authors Info & Affiliations

Science Translational Medicine
19 Nov 2025
Vol 17, Issue 825

DOI: 10.1126/scitranslmed.adu0114

Multiple myeloma cells with chromosome 1q amplification originate from CD24−FCRL5+ B cells and initiate malignant transformation.

14/11/2025

Cosmic dust reveals dynamic shifts in central Arctic sea-ice coverage over the past 30,000 years

Frank J. Pavia https://orcid.org/0000-0003-3627-0179, Jesse R. Farmer https://orcid.org/0000-0001-5200-6429, [...] , and Kenneth A. Farley https://orcid.org/0000-0002-7846-7546+3 authors Authors Info & Affiliations

Science
6 Nov 2025
Vol 390, Issue 6773
pp. 628-632

DOI: 10.1126/science.adv5767

Arctic sea-ice loss affects biological productivity, sustenance in coastal communities, and geopolitics. Forecasting these impacts requires mechanistic understanding of how Arctic sea ice responds to climate change, but this is limited by scarce long-...

14/11/2025

Mechanical power generation using Earth’s ambient radiation

Tristan J. Deppe https://orcid.org/0000-0002-2234-6112 and Jeremy N. Munday https://orcid.org/0000-0002-0881-9876Authors Info & Affiliations

Science Advances

12 Nov 2025

Vol 11, Issue 46

DOI: 10.1126/sciadv.adw6833

Earth's radiation is harvested to power a Stirling engine for air circulation, mechanical work, and electricity.

13/11/2025

Single-nucleus profiling highlights the all-brain echinoderm nervous system
🤯🤯🤯
Periklis Paganos https://orcid.org/0000-0001-9525-4625, Jack Ullrich-Lüter https://orcid.org/0000-0002-2535-2577, [...] , and
🧠🧠🧠
Maria Ina Arnone https://orcid.org/0000-0002-9012-7624+14 authors Authors Info & Affiliations
Science Advances
5 Nov 2025
Vol 11, Issue 45

DOI: 10.1126/sciadv.adx7

A sea urchin is a head with a brain-like organization and a vertebrate-type retinal signature.

07/11/2025

aran sulfate glycocalyx that regulates recruitment during psoriasis-like skin inflammation
Megan J. Priestley
https://orcid.org/0000-0001-7805-2503, Anna K. Hains https://orcid.org/0009-0009-3475-6555, [...] , and Douglas P. Dyer https://orcid.org/0000-0001-5567-6241+10 authors Authors Info & Affiliations

Science Signaling
4 Nov 2025
Vol 18, Issue 911

DOI: 10.1126/scisignal.adr0011

Leukocytes accumulate in the skin during psoriatic-like inflammation upon cleavage of surface heparan sulfate.

06/11/2025

Stem-like tissue-resident memory T cells control functional heterogeneity and reactivation of T cell memory in the intestine

Kevin Man https://orcid.org/0000-0002-6585-9532, Vinicius A. Duarte da Silva https://orcid.org/0000-0002-2865-3375, [...] , and Axel Kallies https://orcid.org/0000-0002-6312-6968+10 authors Authors Info & Affiliations

Science Immunology
31 Oct 2025
Vol 10, Issue 112

DOI: 10.1126/sciimmunol.adw1992

Tissue-resident memory T cells that express TCF1 or ID3 exhibit stem-like properties and regulate memory heterogeneity and recall.

27/10/2025

Science Immunology
24 Oct 2025

Mitochondrial and lysosomal signaling directs Treg cell metabolism

Jordy Saravia Nicole M. Chapman et al.

Mitochondrial and lysosomal signaling orchestrates

Treg cell metabolic states and functional fitness.

Mitochondrial and lysosomal signaling orchestrates Treg cell metabolic states and functional fitness.

24/10/2025

Leucine-rich α-2-glycoprotein 1 initiates the onset of diabetic retinopathy in mice

LRG1-driven microvascular dysfunction triggers early diabetic retinopathy, highlighting a potential therapeutic target.

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