05/04/2026
What REALLY causes Adolescent Idiopathic Scoliosis (AIS)? 🤔
This is a topic I've been intensely interested in since my son was diagnosed. I’ve looked at many theories over the years, but my quest really kicked into high gear when I found a video describing the biomechanics of scoliosis unlike anything I had ever seen before. It featured Dr. Moyo Kruyt from the Netherlands giving a brilliant lecture on bipedalism, disc shearing forces, vertebral instability, and desynchronized growth. (Check out my interview with him from 5 years ago in the link below!)
Through that research, I was introduced to Dr. Rene Castelein. If you haven't seen my interview with him from 4 years ago, I highly recommend checking it out! We recently met up at IMAST 2026 in Toronto to discuss his latest insights on disc growth from childhood to adulthood, and how rotational disc instability can drive scoliosis.
Here is a breakdown of his eye-opening presentation at the IMAST Scoliosis Research Society Breakfast Workshop:
💡 Scoliosis is a Symptom, Not a Disease: Dr. Castelein argues that scoliosis is the result of a biomechanical imbalance. Compared to any other species, our upright posture loads the human spine in ways evolution never fully solved, making it rotationally challenged. He notes that this fragility shows up in three windows: the growing spine (where connective tissue and discs mature unevenly), the aging spine (where degenerated discs create instability), and in various genetic tissue diseases.
🦴 It Starts in the Disc: In idiopathic scoliosis, the deformity actually begins in the disc before the bony changes occur. The ring apophysis—the stage where the vertebral endplate matures and anchors the disc—is measurably delayed in AIS patients. This means a mature mechanical load meets an immature attachment, causing the disc to deform first and the bone to follow.
🏃 The Osgood-Schlatter Analogy: Dr. Castelein flips the script, viewing scoliosis not as a uniform pathology, but as a "stability failure." The closest analogy is Osgood-Schlatter disease: a growing skeleton subjected to forces it cannot yet carry. The body tries to adapt—sometimes well, sometimes not.
🛡️ A New Treatment Rationale: For decades, the field has asked why scoliosis occurs. Dr. Castelein asks a more useful question: What prevents it from occurring? What conditions allow the spine to stay stable through every developmental window? While the data is suggestive and still needs conclusive proof, there is a shift underway. Treating scoliosis as a stability failure to prevent—perhaps by temporarily stabilizing discs in adolescents—opens up a completely different, proactive clinical conversation focusing on earlier, less invasive, mechanism-driven treatments.
I am so excited to be interviewing him again soon to dive deeper into this preventive strategy! :)
Feel free to invite other parents navigating scoliosis to join our private group: https://www.facebook.com/groups/1198200727630801
Dr. Moyo Kruyt https://youtu.be/d4uMy1SuRxU
Dr. Rene Castelein https://youtu.be/XPVlCmM2-6I