Labo Pineyro

09/09/2021

Comprehensive Signaling Profiles Reveal Unsuspected Functional Selectivity of δ-Opioid Receptor Agonists and Allow the Identification of Ligands with the Greatest Potential for Inducing Cyclase Superactivation.

Prolonged exposure to opioid receptor agonists triggers adaptations in the adenylyl cyclase (AC) pathway that lead to enhanced production of cyclic adenosine monophosphate (cAMP) upon withdrawal. This cellular phenomenon contributes to withdrawal symptoms, hyperalgesia and analgesic tolerance that i...

05/17/2021

We're keeping research funds for research. Find thousands of job offers like this one at jobRxiv!

12/09/2019

The project led by Michel Bouvier and Domain Therapeutics with the support of CQDM is awarded the RSRI Recognition Award at the ADRIQ Innovation Prize Gala Montreal, November 22, 2019 – CQDM is proud to announce that the project led by Michel Bouvier from the Institute for Research in Immunology a...

12/05/2019

El desarrollo de nuevos medicamentos es un proceso largo, complejo y caro. Además, con frecuencia los ensayos funcionan bien en laboratorio pero cuando los nuevos fármacos llegan a los pacientes, los efectos indeseables pueden ser muy fuertes y a veces, hasta contraproducentes. Por eso, encontra

12/05/2019

An international research team has developed a new strategy that can predict the potential clinical implications of new therapeutic compounds based on simple cellular responses. This discovery was partly led by scientists affiliated with Université de Montréal (UdeM), and represents a major step f...

09/11/2019

https://www.nature.com/articles/s41467-019-11875-6?fbclid=IwAR17v6GIzPk5w0Ma0Bcg7U3c-ol5cdRYJIwnHTPTX1eKYGGU9NktVOkKpto

Identifying ligands which activate the specific effectors driving particular in vivo drug effects remains challenging. Here, the authors apply unsupervised clustering of pharmacodynamic parameters to classify GPCR ligands into different categories with similar signaling profiles and shared frequency...

06/08/2018

G protein-coupled receptors (GPCRs) are valuable targets for drug discovery. They exist in interconverting states differentially stabilized by diverse…

02/28/2018

Technology provides access to new generation of sensitive biosensors to enhance drug discovery.

02/02/2018

Les Instituts de recherche en santé du Canada (IRSC) ont annoncé des subventions de plus de 9 millions de dollars à vingt-quatre chercheurs du Centre de recherche du CHU Sainte-Justine.

01/02/2018

Immune-like cells in the central nervous system are now recognized as key participants in the creation and maintenance of persistent pain.

01/02/2018

Soon after internalization delta opioid receptors (DOPrs) are committed to the degradation path by G protein-coupled receptor (GPCR)-associated binding protein. Here we provide evidence that this clas

10/25/2017

We were invited to present our research at this year's Great Lakes GPCR Retreat in Ottawa. Great meeting with some great research going on in the field being presented. Here's to next year's meeting in Michigan.