Coastal Care Pharmacy

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Coastal Care Pharmacy

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03/30/2022

Injectable magnesium can be obtained as:

Magnesium chloride hexahydrate 20% solution AKA magnesium chloride,Magnesium sulfate heptahydrate 50% solution AKA magnesium sulfate.

Common question among our doctors is: what is the difference?

Although most clinical research has been done with magnesium sulfate, some experts prefer magnesium Chloride for IV use because of its greater retention in the body.

Whereas magnesium chloride almost exclusively was used for IV therapy, more concentrated magnesium sulfate can be used for IM administration.

🔹Be aware:

For those using magnesium sulfate, it should be noted that 1 g (2 mL of a 50-
percent solution) is equivalent to 0.8 g (4 mL of a 20-percent solution) of magnesium chloride

If 50-percent magnesium sulfate is given IV instead of 20-percent magnesium chloride, it should be diluted appropriately with common diluent.

For doctors: Follow the link in BIO to open the account

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03/28/2022

Magnesium is the fourth most abundant essential mineral in the body.
It is distributed approximately one half in the bone and one half in the muscle and other soft tissues; less than one percent is in the blood.

Possible therapeutic use:

🔹Magnesium is effective for treating eclampsia and preeclampsia.

🔹Intravenous magnesium is effective for treating torsade de pointes and managing rapid atrial fibrillation.

🔹In severe acute asthma, Parenteral magnesium supplementation improves severe acute asthma symptoms

🔹Oral and parenteral magnesium is possibly effective in improving symptoms of migraine.

🔹Magnesium is a widely accepted and effective approach to treat dyspepsia.

For doctors, follow the link in BIO to open the account

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03/25/2022

Facts:

🔹Most cases in adults are probably due to viral infection, but children are more likely to develop bacterial conjunctivitis than viral forms.

🔹A bacterial cause is more likely if there is gluing of the eyelids and no itch.

🔹Contact lens wearers may be more likely to develop gram-negative infections.

🔹Conjunctivitis resolves spontaneously within 2 to 5 days in more than half of people without treatment, but infectious complications can occur.

🔹Topical antibiotic treatment should be considered if symptoms do not resolve or get worse after 2 days.

If you are a pharmacy, contact us today for a stock transfer.

If you are an ophthalmologist or optometrist, we will be happy to work with you on many specialty compounded products that require sterility.

03/23/2022

About one-sixth of glaucoma cases eventually result in blindness.

Eye drops aim to decrease intraocular pressure and are the first-line treatment for patients with glaucoma.

Proper eye drop technique involves multiple steps to instill the medication into the eye for maximum effectiveness without contaminating the bottle.

The literature shows that many glaucoma patients have difficulty with at least one key step in eye drop instillation technique, such as:

🔹Avoiding contamination of the bottle,

🔹Instilling exactly one drop,

🔹Getting the drop accurately into the eye.

Older patients, patients with more severe visual field defect, less educated patients, and patients with comorbidities such as arthritis may be particularly at risk for poor technique.

As providers often do not have time to educate their patients about technique during the medical visit, interventions that can be delivered outside the clinic visit, such as in dispensing pharmacies shown to be particularly helpful and increase the therapeutic success rate.

If you are a pharmacy, contact us today for a stock transfer.

If you are an ophthalmologist or optometrist, we will be happy to work with you on many specialty compounded products that require sterility.

03/21/2022

1. Wash hands to keep the bottle clean when touching it

2. Mix the medication by turning the bottle over several times. Shaking the bottle introduces unwanted air bubbles, but turning the bottle over mixes the medication without creating air bubbles

3.Squeeze the bottle firmly for just long enough to squeeze out one drop, not several drops or a stream of drops. The eye can only hold one drop, so squeezing out multiple drops, even if they are aimed accurately, tends to cause liquid to spill out of the eye and down the face

4. Hold open the lower eyelid with a finger of the nondominant hand to expose the conjunctival sac and get the drop in

5. Avoid touching the eye or face with the bottle tip at any time because of risk of contaminating the bottle with facial microbes

6. Close the eye after instillation for at least 1 min without squeezing it shut

7. Alternatively, perform punctal occlusion by placing a finger over the tear duct and exerting gentle pressure to prevent the medication from traveling through the tear duct into the nose

8. Remove excess fluid from the face with a tissue to avoid localized side-effects on the skin

If you are a pharmacy, contact us today for a stock transfer.

If you are an ophthalmologist or optometrist, we will be happy to work with you on many specialty compounded products that require sterility.

03/18/2022

Ocular drug delivery has always been a challenge for ophthalmologists due to:

Different ocular barriers not only exclude the entry of medications but also discourage the active absorption of therapeutic agents.

Short retention times in the eye caused by rapid tear turnover can contribute to the difficulty of drug diffusion and low bioavailability.

Some of the obstacles may be as simple as blinking reflex or drainage through the nose.

There are many methods that could be utilized to improve eye drop formulation including the addition of:

🔹Viscosity enhancers,
🔹Permeability enhancers,
🔹Muco-adhesives,
🔹Vasoconstrictors

If you are a pharmacy, contact us today for a stock transfer.

If you are an ophthalmologist or optometrist, we will be happy to work with you on many specialty compounded products that require sterility.

03/16/2022

What are the aspects we would need to consider in compounding eye drops:

🔹API quantification – provided by third party testing including potency over time.

🔹Visual inspection: Transparency, color, and presence or absence of visible particles or haziness are verified.

🔹PH measurement: verified with each product compounded using proper equipment.

🔹Sterility: testing provided by third party laboratory

🔹Endotoxin level: testing provided by third party laboratory

If you are a pharmacy, contact us today for a stock transfer.

If you are an ophthalmologist or optometrist, we will be happy to work with you on many specialty compounded products that require sterility.

03/14/2022

Atropine eye drops are indicated for:

🔹Juvenile myopia progression
🔹Cycloplegia
🔹Amblyopia
🔹Strabismus

Although commercially available products are on the market, to avoid systemic adverse effects in pediatric patients, it is necessary to compound the product with particular, prescribed strength.

As it is a long-term treatment, a longer shelf life is necessary to improve patient care.

Whereas the label claim: “Discard 28 days after opening” comes from a parenteral guideline, outlining sterility data and potential contamination after this grace period, stability data are extremely important in order to provide stable supply for patients.

At Coastal Care Pharmacy we test our products for stability and potency over time.

This data gives us documented information based on which we can guarantee BUD- beyond use date.

If you are a pharmacy, contact us today for a stock transfer.

If you are an ophthalmologist or optometrist, we will be happy to work with you on many specialty compounded products that require sterility.

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03/11/2022

🔷Formulas: Consistency of the compounded product is important. Formulas are developed with stepwise methodology:
🔹Method used
🔹Ingredients added
🔹Equipment used
🔹Order of steps documented
🔹Accountability assured

This process provides consistency, accountability and accurate reviewing to determine improvements in the next revisions, if needed.

🔷Chemicals and Supplies: We make sure to use chemicals from various reliable commercial sources that comply with regulations in Canada.

Coastal Care Pharmacy is NAPRA compliant. We make sure to be available to our patients and clients building long lasting relationships.

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03/09/2022

🔷 Th equipment needed will be determined by the type and extent of the services one chooses to provide. While there is some basic equipment necessary to perform the compounding, other, more sophisticated technology is necessary to provide high quality products.

In addition, a policy for the segregation of specific equipment for certain product types must be in place.

Ongoing investment into equipment is prudent, considering that all equipment should be calibrated and validated to demonstrate satisfactory performance.

🔷Environment: A separate area for traditional compounding is a must have. The compounding pharmacist needs a clean, neat, well-lit and quiet working area.

If sterile compounding is performed, in a clean air environment the actual facility has to be compliant with many standards, inspected regularly and it’s performance validated with a third party.

Coastal Care Pharmacy does not give anything to chance. We invest in modern equipment and compounding rooms to make sure it is accurate and high performance by third party validation.

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03/07/2022

One key factor in compounding prescriptions is stability. There are several types of stability to consider:

🔷Chemical

🔷Physical

🔷Microbiological

Whereas commercially manufactured products are required to possess an expiration date, compounded products are assigned a beyond-use date, AKA BUD.

There are numerous sources of information that can be used for determining an appropriate beyond-use date and they are consider as relevant reference to the claim.

Pharmacist expertise in this area is necessary in order to be able to evaluate risk assessment and accurately determinate BUD.

It is essential that the active ingredient does not interact with any excipients used in formulation. Interactions with other ingredients can result in physical instability of the product, such as precipitation of the active drug or phase separation (‘cracking’) of a cream, affecting drug solubility, absorption and bioavailability.

At Coastal Care Pharmacy we don't rely on literature data only, we test our products for:

🔷Stability

🔷Potency over time

🔷Sterility

🔷Endotoxin levels

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03/04/2022

The studies have reported a significant association between serum vitamin D levels and reproductive function.

It has been reported that vitamin D receptors are found in different reproductive tissues including:

🔷Ovary (particularly granulosa cells),

🔷Uterus,

🔷Placenta

🔷Testis

Patients with PCOS exhibit metabolic abnormalities, including insulin resistance and abnormal lipid profile that may affect egg quality.

Moreover, vitamin D deficiency is correlated with poor ovarian stimulation in PCOS but not unexplained infertility.

Vitamin D supplementation is recommended as a potential therapeutic adjunct for the ovulatory dysfunction and metabolic disorders observed in women with PCOS.

If you are a doctor follow the link in BIO to open the account. We have progesterone and estrogen injections available on prescription.

If you are a patient, speak with your doctor about proper supplementation.

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Address

Unit 101/10183 152A Street
Surrey, BC
V3R4H6

Website

http://www.coastalcarepharmacy.ca/

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