01/22/2026
X post from Dr Urato:
https://x.com/i/status/2014310634721063245
"There is general scientific agreement that in utero SSRI exposure impacts fetal brain development.
Common sense, basic science, and animal & human studies all show this.
Twelve (yes 12) consecutive human MRI studies support this.
The studies are listed below:
#1 Zanni, G, et al (2025). Perinatal SSRI exposure impacts innate fear circuit activation and behavior in mice and humans. Nature Communications, 16(1), 4002.
https://www.nature.com/articles/s41467-025-58785-4
#2 Koc, D., et al (2023). Prenatal antidepressant exposure and offspring brain morphologic trajectory. JAMA Psychiatry, 80(12), 1208–1217.
https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2808722
#3 Moreau, A. L., et al (2023). Biological Psychiatry: Global Open Science, 3(2), 243–254.
https://www.sciencedirect.com/science/article/pii/S2667174322000209
#4 Campbell, K. S. J., et al (2021a). Prenatal antidepressant exposure and s*x differences in neonatal corpus callosum microstructure. Developmental Psychobiology, 63(6), e22125.
https://onlinelibrary.wiley.com/doi/10.1002/dev.22125
#5 Salzwedel, A., et al (2020). Functional dissection of prenatal drug effects on baby brain and behavioral development. Human Brain Mapping, 41(15), 4123–4135.
https://onlinelibrary.wiley.com/doi/10.1002/hbm.25158
#6 Rotem-Kohavi, N., et al (2019a). Hub distribution of the brain functional networks of newborns prenatally exposed to maternal depression and SSRI antidepressants. Depression and Anxiety, 36(8), 753–765.
https://onlinelibrary.wiley.com/doi/10.1002/da.22906
#7 Rotem-Kohavi, N., et al (2019b). Alterations in resting-state networks following in utero selective serotonin reuptake inhibitor exposure in the neonatal brain. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 4(1), 49-49
https://www.sciencedirect.com/science/article/abs/pii/S245190221830209X
#8 Lugo-Candelas, C., et al (2018). Associations between brain structure and connectivity in infants and exposure to selective serotonin reuptake inhibitors during pregnancy. JAMA Pediatrics, 172(6), 525–533.
https://jamanetwork.com/journals/jamapediatrics/fullarticle/2676821
#9 Podrebarac, S. K., et al (2017). Antenatal exposure to antidepressants is associated with altered brain development in very preterm-born neonates. Neuroscience, 342, 252–262.
https://www.ibroneuroscience.org/article/S0306-4522(16)30646-7/abstract
#10 Jha, S. C., et al (2016). Antenatal depression, treatment with selective serotonin reuptake inhibitors, and neonatal brain structure: A propensity-matched cohort study. Psychiatry Research: Neuroimaging, 253, 43–53.
https://www.sciencedirect.com/science/article/abs/pii/S0925492716301585
#11 Salzwedel, A. P., et al (2016). Thalamocortical functional connectivity and behavioral disruptions in neonates with prenatal co***ne exposure. Neurotoxicology and Teratology, 56, 16–25.
https://www.sciencedirect.com/science/article/abs/pii/S089203621630054X
#12 Knickmeyer, R. C., et al (2014). Rate of Chiari I malformation in children of mothers with depression with and without prenatal SSRI exposure. Neuropsychopharmacology, 39(11), 2611–2621.
https://www.nature.com/articles/npp2014114"