27/11/2025
Ever wonder how much of an injection's benefit is the injection and how much is the mind? 🤔 When treating knee OA with intra-articular shots, the placebo effect is HUGE!
📊 A massive new systematic review in EFORT Open Reviews looked at 73 studies to quantify the placebo response to saline injections:
🔹 It's Real: The "fake" shot gave clinically significant relief for pain, function, and QoL at 1, 3, and 6 months. Over 50% of patients were "responders." 🤯
🔹 It Lasts: The effect peaks surprisingly late—between 4 and 8 months!
🔹 Who Responds Best? The placebo response was stronger in women and in newer studies.
👉 his confirms: If your trial doesn't have a placebo arm, your results are likely inflated! Essential reading for anyone managing knee OA! 👇
🔗 Read the full article here: https://bit.ly/EOR102507
🧑🎓Author(s): Davide Previtali, Angelo Boffa, Giorgio Di Laura Frattura, Giulia Merli, and Giuseppe Filardo
🔔 Stay at the forefront of orthopaedic research – subscribe to EOR updates: https://bit.ly/eor_subscribe