Center for Molecular Cardiology

02/09/2022

Early risk stratification is key to guide the management of patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS). F Wenzl et al. developed the improved machine learning-based GRACE 3.0 score which provides increased predictive performance and accounts for s*x differences in disease characteristics. Check out the full study (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)01483-0/fulltext) led by the CMC and published in The Lancet (https://www.thelancet.com).

Summary Video (https://twitter.com/UZH_en/status/1564884215983915008)
Presentation at the ESC Congress 2022 (https://esc365.escardio.org/session/37132)
Communication by the University of Zurich (https://www.news.uzh.ch/en/articles/media/2022/Heart-Attack-Treatment.html)
Paper (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)01483-0/fulltext)
Editorial Comment (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)01607-5/fulltext

Florian Wenzl Simon Kraler European Society of Cardiology The Lancet UCL

24/03/2022

A soluble form of the endothelial scavenger receptor LOX-1 is increased during acute coronary syndromes, and predicts both mortality & plaque progression in a large, multicentre prospective study, now online ahead of print in the European Society of Cardiology . Check out the full manuscript:
https://academic.oup.com/eurheartj/advance-article-abstract/doi/10.1093/eurheartj/ehac143/6553339 Alexander Akhmedov Universität Zürich Unispital Zürich European Atherosclerosis Society (EAS) & Congress Luca Liberale Florian Wenzl

07/12/2021

Ever thought about medical therapies for instead of having AVR/TAVI? Most promising therapeutic targets and the main mechanisms involved, now comprehensively reviewed in the : https://doi.org/10.1093/eurheartj/ehab757
Harvard Medical SchoolUniversität Zürich Zurich Heart House European Society of Cardiology Interventional Cardiology Cardiology Cases Theheart.org/Medscape

Abstract. Calcific aortic valve disease (CAVD) is a highly prevalent condition that comprises a disease continuum, ranging from microscopic changes to profound

26/10/2021

Inflammatory pathways are pivotally implicated in the pathogenesis of metabolic cardiomyopathy - a condition that commonly precedes heart failure with preserved ejection fraction (HFpEF). Check out this review article by Florian Wenzl and colleagues from University of Zurich Center for Molecular Cardiology European Society of Cardiology Medical Journal Club - Graz Simon Kraler

https://doi.org/10.3389/fcvm.2021.742178

13/07/2021

What protects the mammary artery from atherosclerosis? Check out this review article by Simon Kraler and Peter Libby about possible mechanisms and possible future implications. Now up ATVB! University of Zurich Harvard Medical School Brigham and Women's Hospital American Heart Association European Society of Cardiology Zurich Heart House

The mammary artery resists atherogenesis 2/2 anti-inflammatory flow and unique biology.

http://ow.ly/qSzQ50FuiHx

29/05/2021

30/04/2021

Statins have failed to halt calcific aortic valve disease progression. Can multi-comics approaches pave the way for successful drug discovery? Check out our review article by M Bl**er et al in
Circulation Research: https://doi.org/10.1161/CIRCRESAHA.120.317979

23/02/2021

Targeting protein misfolding in cardiovascular diseases: a long and winding road? Check out this comprehensive article summarizing recent advances of protein misfolding and altered protein quality control by Thamonwan Diteepeng et al. published recently in the EJCI https://onlinelibrary.wiley.com/doi/10.1111/eci.13504

11/11/2020

The role of modified and its endothelial scavenger receptor LOX-1 in and beyond: check out our recent review authored by Alexander Akhmedov et al. which has been published in the recently https://doi.org/10.1093/eurheartj/ehaa770
Science UZH Alumni - Universität Zürich - University of Zurich Zurich Heart House European heart journal Oxford Academic (Oxford University Press) European Society of Cardiology

07/11/2020

Do you have a competitive CV? Interested to pursue a PhD or postdoc in an internationally renowned research group? Apply now!

23/10/2020

A gout drug to fight ischemic heart disease? Check out the editorial by Simon Kraler and Florian Wenzl about the LoDoCo2 trial which has been published in The New England Journal of Medicine. Now available online at https://onlinelibrary.wiley.com/doi/abs/10.1111/eci.13424 Wiley Microbiology The Medical Journal Club - Graz Universität Zürich Universitätsspital Zürich European Society of Cardiology

16/10/2020

Luca Liberale and colleagues identified a novel role for Sirtuin 5 in arterial thrombosis: https://academic.oup.com/cardiovascres/advance-article/doi/10.1093/cvr/cvaa268/5906027