21/11/2022
A blood genotype indicates the genetic makeup of an individual’s blood in its entirety.
Typically, there are five (5) distinct types of blood genotype. They are AA, AS, AC, SS, and SC. While the first 2 pairs (AA & AS) are normal, AC is rare and the latter two (SS, SC) are irregular and anomalous, commonly causing sickle cell disease. Sickle cell disease occurs when an individual’s blood cells are shaped in a deformed and abnormal manner, potentially blocking blood flow, causing pain and damage to vital organs.
The AS genotype is best compatible with the AA. A genotypic pairing of AS with AS or AS with AC poses an increased chance of sickle-celled offspring. Similarly, a pairing between AS and SS or the AC and SS is equally as risky and ill-advised, while a pairing of two sickle-celled individuals will almost certainly result in sickle-celled offspring.
AA + AA = AA, AA, AA, AA (Excellent)
AA + AS = AA, AS, AA, AS, (Good)
AA + SS = AS, AS, AS, AS, (Fair)
AA + AC = AA, AA, AA, AC. (Good)
AS + AS = AA, AS, AS, SS, (Very Bad)
AS + SS = AS, SS, SS, SS, (Very Bad)
AS + AC = AA, AC, AS,SS. (Bad; Advice needed)
SS + SS = SS, SS, SS, SS, (Very Bad)
AC + SS = AS, AS, SS, SS, (Very Bad)
AC + AC = AA, AC, AC, SS. ( Bad; Advice needed)