19/11/2025
The role of selenium for patients to complement, used alongside the treatment for mild Graves' Disease, particularly to improve quality of life and reduce eye problems in patients with mild Thyroid Eye Disease:
The inflammatory process is characterized by:
📍an imbalance of the antioxidant-oxidant mechanism
📍increased production of radical oxygen species (ROS) and cytokines, which sustain the autoimmune process and perpetuate the disease.
Selenium, a powerful antioxidant, has been applied in patients with mild Graves' Disease and Thyroid Eye Disease:
📍to slow the progression of the disease
📍to decrease the clinical activity score
📍to improve the quality of life of patients
Selenium, as selenocysteine, is incorporated into selenoproteins, such as glutathione peroxidase, which catalyzes the degradation of hydrogen peroxide and lipid hydroperoxide that are increasingly produced in hyperthyroidism.
Selenium:
📍may decrease the formation of proinflammatory cytokines,
📍may contribute, in synergy with antithyroid drugs, to the stabilization of the autoimmune process in Graves' Disease and alleviation of Thyroid Eye Disease.
While selenium may be used as a complementary used alongside current treatment options for Thyroid Eye Disease, significant research and clinical trials are underway to develop more effective management strategies for Thyroid Eye Disease.
