13/11/2025
🦷 Cavities may soon be reversible — scientists just developed a gel that regrows enamel!
In a breakthrough that could transform dentistry, researchers at the University of Nottingham have developed a protein-based gel that can regrow tooth enamel — something once thought impossible.
Tooth enamel, the body’s hardest tissue, doesn’t naturally regenerate, making cavities and enamel erosion permanent problems. But this new gel mimics the body’s early-life enamel formation process. When applied to a tooth’s surface, it extracts calcium and phosphate ions from saliva to grow mineral crystals that merge seamlessly with existing enamel, effectively rebuilding the tooth.
Lab tests on extracted human molars showed that a protective enamel-like layer began to form within just one week. The regenerated surface held up under simulations of daily wear, including brushing, chewing, and acidic food exposure. Though the gel hasn’t yet been tested in live human mouths, early results are promising enough to launch a startup, Mintech-Bio, and schedule clinical trials for early next year. If successful, the technology could provide a single-step, non-invasive solution for millions suffering from tooth erosion and decay — a true game-changer in oral health care.
Source: “Protein-based gel promotes biomimetic mineralization of enamel-like tissues.” Nature Communications, 2025