PEPperPRINT GmbH

11/08/2022

Learn how PEPperCHIP® Custom Peptide Microarrays can be used for biomarker discovery of potentially diagnostic peptides against Hepatitis E viral infections. By performing in depth-analyses of immune profiles of infected and non-infected patients, we identified immunodominant epitopes that could later on be transferred to a diagnostic platform. Download our application note: https://buff.ly/32OZChX

09/08/2022

Working in vaccine development or antibody-based therapeutics? Analyze and monitor humoral immune responses with PEPperMAP® Immnune Monitoring. Identify antigenic targets and distinguish between strongly and weakly immunogenic epitopes by comparing pre- and post-treatment antibody response profiles. Learn how it works:

Immune Monitoring enables fingerprint analysis of antibody responses upon immunization, vaccination or administration of biopharmaceutical drug.

03/08/2022

Analyzing vaccine-induced immune responses is important to determine the immunogenicity of a given vaccine. Learn how we analyzed pre- and post- COVD-19 vaccination sera of healthy volunteers to identify and validate vaccination-induced responses using a combination of peptide microarrays and bead-based multiplex immunoassays in this free application note: https://buff.ly/3HLVaPX

28/07/2022

Publication feature: A recent study by Fahnoe and colleagues report on a novel bifunctional fusion protein designed as a tissue-targeted anti-complement therapy. The fusion protein consists of an anti-C3d monoclonal antibody linked to a negative regulator protein for binding to C3/C5 convertases, which have shown effective localized complement inactivation in vitro and in vivo. Linear epitope mapping validated binding specificity of the mAb portion to C3d. Read the paper here:

Sustained complement activation is an underlying pathologic driver in many inflammatory and autoimmune diseases. Currently approved anti-complement therapies are directed at the systemic blockade of complement. Consequently, these therapies provide widespread inhibition of complement pathway activit...

26/07/2022

Get the most information out of your antibodies and take epitope identification one step further with PEPperMAP® Epitope Substitution Scan. Find conserved and variable amino acid positions, discover epitope variants, or optimize sequences for binding. Find out how:

Epitope substitution scans allow determination of conserved and variable amino acids, cover stepwise substitution of amino acid positions.

19/07/2022

Did you know that PEPperCHIP® Custom Peptide Microarrays can be fully tailored to your scientific objectives? Whether you are looking to analyze antibodies, sera, or even proteins, we can create a unique peptide microarray for your project. From having single antigens to whole virus proteomes, each chip can be made with either linear or cyclic constrained peptides, as well as adapted to multiple chip formats to accommodate different experimental designs. Analyze several samples at once or screen against different antigens in one assay. Learn more: https://buff.ly/31IJezg

23/06/2022

Publication feature: A 2022 study by Parsons and colleagues report on 11 broadly neutralizing human monoclonal antibodies against cytomegalovirus developed from mice immunized with gH/gL cDNA. Conformational mapping by peptide microarrays revealed conserved gH region epitopes. Read the paper here: https://buff.ly/3xCOxMA

16/06/2022

We're excited to be at the congress next week! If you're attending, drop by our booth and chat with our team to learn more about how we can support your cancer research with our PEPperCHIP® Peptide Microarray Technology. See you in Seville!

15/06/2022

In this application note created in cooperation with Rockland Immunochemicals Inc., we tested and compared different blocking reagents for performing immunoassays with PEPperCHIP® Peptide Microarrays by evaluating their signal-to-noise ratios. Read and download the application note here: https://buff.ly/3xOsfsG

09/06/2022

PEPperPRINT is excited to share our results from a long-term study aimed at identifying novel biomarkers for early detection of rheumatoid arthritis. The findings will be presented during a talk at the 13th International Congress on Autoimmunity to take place in Athens, Greece, from June 10-13th. Read the press release: https://www.b3cnewswire.com/202206092363/pepperprint-gmbh-introduces-novel-biomarker-set-for-rheumatoid-arthritis-diagnosis-at-the-13th-international-congress-on-autoimmunity.html

24/05/2022

Identify epitope-level antibody responses against 27 human cytokines in one assay with the new PEPperCHIP® Human Cytokine Microarray. The microarray can be used to monitor autimmune responses, identify susceptibility to infectious diseases, or characterize anti-human cytokine responses for IVD or therapeutic antibody development. Download the data sheet to learn more: https://buff.ly/3MKY6PS

10/05/2022

Profile antibody responses against 15 AAV capsid proteins with the PEPperCHIP® Pan-AAV Capsid Protein Microarray. Available with linear or cyclic constrained peptides for linear or conformational epitope mapping, the PEPperCHIP® Pan-AAV Capsid Protein Microarray can be used to analyze patient and animal sera as well as research and diagnostic anti-AAV antibodies on the epitope level. Learn more:

For research use only: Profile antibody responses against the most important wild type and chimeric AAV capsid proteins with the PEPperCHIP® Pan-AAV Capsid Protein Microarray. The chip contains the sequences of 23 different capsid proteins converted into more than 4,000 overlapping peptides for hig...