Center for Surgical Science

Center for Surgical Science We aim to change the future for surgical patients, focusing our research on personalised medicine ⚕

I går var Center for Surgical Sciences leder, professor Ismail Gogenur i Go' morgen Danmark studiet sammen med en af vor...
22/10/2025

I går var Center for Surgical Sciences leder, professor Ismail Gogenur i Go' morgen Danmark studiet sammen med en af vores tidligere patienter for at tale om præhabilitering og resultaterne fra arbejdet med vores AI-model som beslutningsstøtte.

Vi er stolte af at vi når bredt ud til befolkningen og at danskerne i går, til morgenkaffen, kunne lære mere om hvordan AI er ved at forandre patientbehandlingen på kræftområdet.

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“Patienterne har utroligt meget at vinde” ❤️

Christian Iermiin fik konstateret tarmkræft tidligere i år. I stedet for at få en operationsdato hurtigst muligt, fik han besked på at påbegynde at træningsbeløb.

“Jeg måtte jo regne med, at de vidste, hvad de gjorde — eller at de var på ferie,” siger han med et smil.

Overlæge og professor Ismail Gögenur fortæller, at patienter på bare fire til seks uger kan løfte lunge- og hjertefunktion så meget, at kroppen bedre kan modstå stress og komplikationer ved en operation — særligt hos ældre patienter.

“Man kommer sig hurtigere, og risikoen for tilbagefald er mindre,” fortæller Ismail.

Samtidig får lægevidenskaben nu hjælp fra kunstig intelligens. Med 3,68 mio. kroner fra Knæk Cancer 2022 undersøger forskere, hvordan AI kan vurdere kræftpatienters behov for træning inden operation — baseret på data fra 76.000 patientforløb.

Det gør det muligt at forudsige, hvilken behandling der passer bedst til den enkelte patient.

“Det er ikke fordi, vi ikke er dygtige — men vi bliver endnu dygtigere, når vi kan tage erfaringer fra titusindvis af patienter med ind i konsultationsrummet,” lyder det fra overlægen.

📣New article alert: AI-supported perioperative care and surgery for colorectal cancer! We are happy to announce that our...
19/09/2025

📣New article alert: AI-supported perioperative care and surgery for colorectal cancer!

We are happy to announce that our experiences at Center For Surgical Science and Kirurgisk Afdeling Sjællands Universitetshospital Køge on implementing personalized perioperative care supported by AI, are now available online, and grateful that Nature Medicine have chosen to publish it as an a-z article for developing, testing and implementing a digital solution for clinical use.

The article tells a story from identifying a clinical need, building a digital solution, implementing the tool with bundle-care clinically, and evaluating the health economic outcomes.

The story starts with how researchers at Center for Surgical Science (CSS), together with the colorectal surgical team needed to identify high risk patients, how they co-designed, -developed, and validated a decision support tool based on Danish Registry data, using the OHDSI tool stack, validation on the tool on patients from the clinic, and how the relative incidence of adverse postoperative events changed after implementing the tool together with care-bundles - And finally how changing healthcare utilization might be changed by a new treatment paradigm of using AI based tools to personalize perioperative care.

A few highlights from the article:

⭐ The registry-based model performed well and generalized to the real-world setting

🏥 34-48% relative fewer adverse postoperative outcomes were observed after implementation of personalized preoperative care

💰 Expected reduced healthcare utilization valued at ~2800 USD per patient due to less postoperative morbidity

We are very excited about the project's findings as they already help clinicians improve care for patients with colorectal cancer, but we also hope our study can serve as a road map between researchers and clinicians within other disease and treatment areas to guide the development and deployment of new tools.

The study is a true team effort between all our colleagues and collaborators at the Surgical Department, PROgrez, Department of Anesthesiology, geriatric department, DaCHE - Dansk Center for Sundhedsøkonomi / Danish Centre for Health Economics and CSS, guided by the leadership of Ismail Gogenur 🤗

The main authors are our two amazing doctors Ilze Ose and Andreas Weinberger Rosen, but we would also like to say thank you for the contribution to our own Mikail, Philip, Rasmus V & Rasmus B.

Thanks to the clinicians at the Surgical Department and of all the guidance from Trine Kjær, Søren Thorgaard Skou, Lars Peter and a special thanks to the editors, technical team and reviewers at Nature Medicine.

Thanks to Aage and Johanne Louis-Hansen Fonden, Novo Nordisk Foundation, Danish Agency for Digital Government and InteregØKS, for the invaluable support.

Read the full paper here: https://www.nature.com/articles/s41591-025-03942-x

🩺 Meet our PhD student, Dr. Michael Chieng!We are very excited to have this talented researcher as a part of our team – ...
12/09/2025

🩺 Meet our PhD student, Dr. Michael Chieng!

We are very excited to have this talented researcher as a part of our team – Our PhD fellow who travelled all the way from New Zealand 🌏

Michael is both a skilled doctor and a true people person – the perfect combination!

Earlier this year he moved to Denmark with his Danish wife, and he quickly embraced the lifestyle of the danes. He loves the biking culture, and he is taking language classes in the evening (to impress his “svigermor” but his colleagues are impressed as well 😉…)

Michael’s research revolves around how microbiota and biofilms influence colorectal cancer development and treatment, combining microbiology, oncology, and clinical innovation.

With his ambition and curiosity, it’s only natural that Michael is already deeply involved in three projects:

🔬 Project 1: Characteristics of mucosa-adherent microbiota and biofilms in patients with pre-cancerous polyp lesions: A multi-omic diagnostic study investigating bacterial communities in polyps and surrounding tissue, an area that remains underexplored compared to cancer research.

💡 Project 2: Bacterial traits that predict outcomes in neoadjuvant immunotherapy for deficient mismatch repair colon cancer: Leveraging samples from the RESET-C study to identify bacterial features that may predict responses to immune checkpoint inhibitors.

🌐 Project 3: ENABLE RCT: An international, multi-centre phase II randomized controlled trial testing the effect of endoscopically applied topical antibiotics against biofilm-forming bacteria to prevent metachronous colonic lesions. Recruitment will span Denmark, Japan, and the UAE.

We are very excited to see his contributions in the years ahead.

And a fun fact: Michael once competed internationally as a gymnast and still shows off some moves on the trampoline! But it will probably be his research results that he will be presenting to the public from now on… ☺️

Forskning holder ikke (helt) sommerferie ☀️🔬 Der er mere stille end normalt i Center for Surgical Science (CSS) i disse ...
25/07/2025

Forskning holder ikke (helt) sommerferie ☀️🔬

Der er mere stille end normalt i Center for Surgical Science (CSS) i disse juli-uger, men helt fri holder vi ikke! 💪

I laboratoriet er Randi Melohn i dag i fuld gang med at oprense Paxgene rør på C-og D patienter til vores vores nationale prehab studie, som omhandler præhabilitering. De skal sendes til Novogene Europe i Tyskland, hvor de skal sekventeres.

Derudover indkapsler hun også biopsi-væv fra patienter i paraffin, så det kan gemmes og bruges til relevant forskning i fremtiden 🏥

God sommer fra os, uanset om du holder fri eller er på arbejde!

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Researching ways to reduce stress in surgical procedures

The Center for Surgical Science was founded in 2015 to research the physiological changes caused by a surgical procedure.

It is generally acknowledged that even small surgical procedures can affect the patients’ sickness and mortality rates after an operation. A lot of focus has been put in recent years on finding ways to reduce physiological stress in relation to surgery, so that patients experience pain, fatigue, heart problems, sleep disturbances, depressive symptoms and impaired immune response to a minimum degree.

One of our major research areas at CSS is the characterization of surgical stress associated with surgery. We investigate which genetic inflammatory, oxidative and immunological changes can follow a cancer surgery. This knowledge will later be the basis for a “proof-of-concept” study about short-term preoperative treatment with immunosuppressive or anti-flammatory medication.

We also have studies on benign surgery, where we research the different treatments in patients with hernia and the complications after hernia surgery.