12/01/2026
What is new in pediatrics ?!
Tonsillectomy for periodic fever with aphthous stomatitis, pharyngitis, and adenitis (January 2026)
Periodic fever with aphthous stomatitis, pharyngitis, and adenitis (PFAPA) is a periodic fever syndrome that is self-limited and has no long-term sequelae, but it can negatively impact quality of life. Thus, choice of therapy is highly dependent upon patient/caregiver preferences and potential adverse effects of each therapy. A meta-analysis of randomized trials and observational studies with 691 children found that tonsillectomy was associated with decreased symptom burden compared with medical treatment. This analysis confirms that tonsillectomy is a reasonable treatment choice, particularly for patients who do not respond to or tolerate medical management or whose episodes are frequent, highly disruptive, and affect quality of life.
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