23/06/2020
lack of Solar (UVBR) exposure, not just vitamin D deficiency is the culprit in COVID-19 sever symptoms and high mortality rate.
Surprise, Surprise!! 🤫😮
The month of June has provided us with some cheering breakthroughs on our way to find a solid and efficient remedy to the , the most baffling pandemic of the modern history.
So what's this remedy might be? Is it an antiviral drug? Cortisone? Or some other complicated drug?!
Simply NONE of the above!!
There have been many may wrong concepts and mismanagement of the global medical society regrading how and what was transferred to the public.
Vitamin D, the most commonly known metabolite of the UVBR and human skin interaction, there are other more importantly potent metabolites modulating the immune system, is not just a vitamin, but it's a hormone that plays an epigenetic (controls genes' expression) role, deficient serum vitamin D level triggers bad genes expression giving rise for disease development (Autoimmune diseases, Allergies, Cancer, Depression, Cardiovascular diseases, ......). Some will try to convince you that it is just a vitamin and would protect you and increase your immunity against or make you overcome it with mild or moderate symptoms only if you take it within FDA outdated recommendations (800 IU- 100 IU/ day) but not the higher doses, and it is not a remedy; Study 6. Which keeps you away from the real remedy because taken these futile doses by a globally vit.D deficient populations would not help whatsoever to change the weak immune system or modulate it to fight the disease. Only moderate loading doses applied by physicians with good vit.D background can indeed help.
So, the trick here is the correct dosing!!
However, it's not how much to take, it's more importantly WHEN to take the moderate to high doses!
To answer the When question, we must divide treatment period into three possible stages. 1st stage: BEFORE , 2nd Stage: during mild, moderate, and SEVER contagion, and 3rd stag: Post .
I will focus in this post only on the dose of vitamin D3 or more preferably UVBR (3X more potent than the Vit.D3 supplements, from my last clinical trial results, see Dr. Essa's studies link) in SEVER symptoms. that is when the cytokine storm starts and evident by the elevated serum D-Dimer and decreased O2 saturation than normal levels. Cortisone ( Dexamethasone,see study 3, or medrol) here, and only here, is the drug of choice to calm down the immune system and cut down the need for ventilation and mostly consequent mortality. But, in my opinion, it would work much faster if the dose is much higher the study offered (2mg/day for 10 days) to be 1 g/day intravenous infusion for 3-5 days , as it's standardly used dose to treat attacks of most of the autoimmune diseases (e.g. Multiple sclerosis , ). Followed by moderate dose proposed in my previous study (Essa's studies) or the current multicenter RCT, see Study 5 or study 4, or more safely to avoid overdosing in this stage UVBR therapy would be the best choice). BUT, why don't we just use these high vit.D3 doses as our first line of treatment and choose cortisone instead?????
BECAUSE, if we do so we will kill the patient much more faster!!!!!
What most health care professionals do not know is that giving high doses of vit.D3 or UVBR during immune flare will only exacerbate the flare and worsen the case. (see Study 7)
Which is not the case before or after the flare, in contrast, vit.D3 or UVBR therapy are our remedy of choice with no need for any other pharmacological drugs.
Herby, and up on not only observational studies but also big ongoing phase 3 RCTs. vitamin D deficiency is suggested to be the major cause of the fatal immune autoaggression in sever cases. and also the prophylactic factor before the viral contagion and the therapeutic remedy for the (CFS) that ensues , / infection.
Please, see my previous studies regrading and down below.
References:
More evidence that lack of vitamin D is linked to COVID-19 severity
Study 1 Links:
https://www.thejakartapost.com/life/2020/06/20/more-evidence-that-lack-of-vitamin-d-is-linked-to-covid-19-severity.html
https://nutrition.bmj.com/content/early/2020/06/14/bmjnph-2020-000110
The Possible Role of Vitamin D in Suppressing Cytokine Storm and Associated Mortality in COVID-19 Patients
Study 2 Link:
https://www.medrxiv.org/content/10.1101/2020.04.08.20058578v4
Dexamethasone reduces death in hospitalised patients with severe respiratory complications of COVID-19
Study 3 Link: http://www.ox.ac.uk/news/2020-06-16-dexamethasone-reduces-death-hospitalised-patients-severe-respiratory-complications
Vitamin D on Prevention and Treatment of COVID-19 (COVID-19)
Study 4 link: https://www.clinicaltrials.gov/ct2/show/NCT04334005
COvid-19 and Vitamin D Supplementation: a Multicenter Randomized Controlled Trial of High Dose Versus Standard Dose Vitamin D3 in High-risk COVID-19 Patients (CoVitTrial)
Study 5 link: https://clinicaltrials.gov/ct2/show/NCT04344041
Vitamin D and SARS-CoV-2 virus/COVID-19 disease
Study 6 link: https://nutrition.bmj.com/content/early/2020/06/10/bmjnph-2020-000089
Exposure to Ultraviolet Radiation in the Modulation of Human Diseases
Study 7 link:
https://www.annualreviews.org/doi/10.1146/annurev-pathmechdis-012418-012809
Dr. Essa's Studies
https://www.researchgate.net/profile/Shimaa_Essa
