23/06/2016
Abstract
AIM: To performed remains a subject of debate and is
the principal aim of the study.
METHODS: This retrospective analysis included 73
patients with emphysema (2000-2012). The outcomes
of patients undergoing single-lung transplantation (SL)
(n = 40) or double-lung transplant (DL) (n = 33) were
compared in a Cox multivariate analysis to study the
impact of the technique, postoperative complications
and acute and chronic rejection on survival rates.
Patients were selected for inclusion in the waiting list
according to the International Society of Heart Lung
Transplantation
criteria. Pre and postoperative rehabilitation
and prophylaxis, surgical technique and immunosuppressive
treatment were similar in every patients.
Lung transplantation waiting list information on a national
level and retrospective data on emphysema patient
survival transplanted in Spain during the study period,
was obtained from the lung transplantation registry
managed by the National Transplant Organization
(ONT).
RESULTS: Both groups were comparable in terms of
gender and clinical characteristics. We found significant
differences in the mean age between the groups, the DL
patients being younger as expected from the inclusion
criteria. Perioperative complications occurred in 27.6%
SL vs 54% DL (P = 0.032). Excluding perioperative
mortality, median survival was 65.3 mo for SL and 59.4
mo for DL (P = 0.96). Bronchiolitis obliterans and overall
5-year survival were similar in both groups. Bacterial
WJT|www.wjgnet.com June 24, 2016|Volume 6|Issue 2|
World J Transplant 2016 June 24; 6(2): 000-000
ISSN 2220-3230 (online)
© 2016 Baishideng Publishing Group Inc. All rights reserved.
Submit a Manuscript: http://www.wjgnet.com/esps/
Help Desk: http://www.wjgnet.com/esps/helpdesk.aspx
DOI: 10.5500/wjt.v6.i2.000
World Journal of
W J T Transplantation
Single-lung transplantation in emphysema: Retrospective
study analyzing survival and waiting list mortality
Retrospective Cohort Study
