alexis_ortega_md

04/11/2025

Deleterious effects of TOO MUCH CORTISOL ACTIVATION 🔥

• It inhibits p53, the guardian that suppresses tumour development. ❌
• It blocks muscle and bone synthesis, accelerating frailty.❌
• It reduces insulin sensitivity, paving the way to diabetes.❌
• It suppresses SIRT1, a longevity deacetylase tied to cellular repair. ‼️
• It dysregulates FOXO3a & mTOR/REDD1 axis, impairing autophagy and protein synthesis. 🧨
• It shortens telomeres over time, accelerating cellular aging. ⏳

No supplement replaces stress management, enough restful sleep, meditation, taking days off and rethinking your life to avoid permanent high blood cortisol.

Regardless, here are some which have proven to help counteract cortisol & its metabolites:

• Magnesium (only organic salts such as malate, orotate, taurate, glycinate, & threonate). 200-400 mg/d.
• Phosphatidylserine 200-400 mg/d
• DHEA. (under strict medical supervision) 5-50 mg/d.
• Ashwagandha. 600 mg/d taking days off.
• Rhodiola. 200-400 mg/d taking days off.
• Ginseng 200-400 mg/d
• Taurine. 1-3 g/d
• Phelodendron + Magnolia 250 mg x3/d
• L-Theanine 500 mg/d.

🇪🇦 Efectos perjudiciales de una ACTIVACIÓN EXCESIVA del CORTISOL 🔥

• Inhibe p53, el “guardián” que suprime el desarrollo tumoral. ❌
• Bloquea la síntesis de músculo y hueso, acelerando la fragilidad. ❌
• Reduce la sensibilidad a la insulina, allanando el camino hacia la diabetes. ❌
• Suprime SIRT1, desacetilasa de longevidad clave en la reparación celular. ‼️
• Disregula FOXO3a y el eje mTOR/REDD1, perjudicando la autofagia y la síntesis proteica. 🧨
• Acorta los telómeros con el tiempo, acelerando el envejecimiento celular. ⏳

Ningún suplemento sustituye la gestión del estrés, el sueño reparador, la meditación, los días de descanso y replantear tu estilo de vida para evitar un cortisol crónicamente elevado.

Suplementos que pueden ayudar:

• Magnesio (malato, orotato, taurato, glicinato, treonato): 200–400 mg/d
• Fosfatidilserina (PS): 200–400 mg/d
• DHEA (solo con supervisión médica estricta): 5–50 mg/d
• Ashwagandha: 600 mg/día, con días de descanso.
• Rhodiola: 200–400 mg/día, con días de descanso.
• Ginseng (Panax) 200-400 mg/d
• Taurina 1-3g/d, L-teanina 500/d

02/10/2025

🚫🦷 Did you know your toothbrush might be feeding you microplastics every single day?

Recent studies show that we swallow and inhale tens of thousands of microplastic particles per year — and they’ve already been found in human blood, lungs, and even the placenta (PMID: 35361530, 35748804).

Microplastics trigger oxidative stress, chronic inflammation, and may disrupt hormones, accelerating the same biological aging processes we fight against in longevity medicine (PMID: 34484171, 34899313).

As a longevity doctor, I always tell my patients: what we avoid is just as important as what we add.
👉 Switch your regular plastic brush for bamboo charcoal microfibre heads — gentle on gums, effective on plaque, and ZERO microplastics.

Small swaps today → massive health impact tomorrow.
🧬 Longevity is in the details."

✨ Save this hack & share it with someone who still uses plastic toothbrushes!

25/09/2025

🇪🇦 Otro resultado de mi trabajo rejuveneciendo la piel con mi protocolo, que combina fórmulas magistrales de uso en casa con tratamientos en la clínica (peelings, láser, bioestimuladores). En el escáner multiespectral se objetiva la reducción del número y profundidad de arrugas, reducción de la inflamación/sensibilidad cutánea y del daño actínico/solar. ✨

🇬🇧 Another result of my work rejuvenating skin with my personal protocol of at-home formulas, plus in-office treatments (peels, lasers, biostimulators). The multispectral scanner shows reduced number and depth of wrinkles, red areas and sun damage. ✨

19/09/2025

🇪🇦 | CASO #1: Rejuvenecimiento de piel SOLO con nuestras Fórmulas Magistrales

Desliza ⬅️ para el antes/después.

Aquí tratamos exclusivamente con las fórmulas propietarias de , diseñadas para reparar la barrera, calmar la rojez y remodelar la dermis:

Nuestro set propietario:

👉🏻Crema de noche con ácido retinoico, péptidos bioactivos y probióticos

👉🏻Sérums de día con multivitaminas, proteoglicanos e hidratantes

👉🏻 Fotoprotección asesorada a medida.

Resultados de nuestro Escáner Multiespectral:

Arrugas: ~68% → ~58%

Sensibilidad/Eritema (mapa de hemoglobina): ~92% → ~34%

Poros: ~92% → ~84%

Edad de piel estimada: 55 → 53

✨ Los resultados son aún más increíbles cuando combinamos con polinucleótidos (PN/PDRN), tecnología láser y factores de crecimiento. Pregunta por nuestros tratamientos combinados.

📍 Ad Astra Clinic | Barcelona
📩 (Whatsapp) 655879040

🇬🇧 | Skin Rejuvenation using ONLY our Compounded Formulas

Swipe ⬅️ for before/after.

In this case we used only proprietary compounded formulas, tailored to repair the barrier, calm redness and remodel dermis:

Our proprietary set

👉🏻Night cream with retinoic acid, bioactive peptides and probiotics

👉🏻Day serums with multivitamins, proteoglycans and moisturisers.

👉🏻Targeted sunscreens.

Multispectral Scan results:

Wrinkles: ~68% → ~58%

Redness/Sensitivity (hemoglobin map): ~92% → ~34%

Pores: ~92% → ~84%

Skin age estimate: 55 → 53

✨ Results get even better when we combine with polynucleotides (PN/PDRN), laser technology and growth factors. Ask about our combo plans.

📍 Ad Astra Clinic | Barcelona
📩 WhatsApp +34 655879040 for info on our treatments.

Individualized medical prescription. Results vary with adherence and baseline skin.

17/09/2025

‼️Did you know too much blue light damages your mitochondria?‼️

Every time you stare at your phone, laptop, or LED lights, artificial blue light (415–455 nm) penetrates your cells and hits the mitochondria – the tiny powerhouses that produce your energy.🔋

🔬 Science is clear:

👉🏻Blue light triggers reactive oxygen species (ROS), creating oxidative stress inside mitochondria (PMID: 15191057, 29459695).

👉🏻It damages mitochondrial DNA and lowers ATP production – the energy currency of your cells (PMID: 15797866, 28315451).

👉🏻Long-term exposure impairs mitochondrial dynamics, leading to cell death and accelerating aging (PMID: 36724628).

👁️ These effects are seen in the skin, retina, and even brain cells. Over time, they may contribute to:

Photoaging (wrinkles, pigmentation)

Retinal degeneration

Faster biological aging

✨ How to protect your mitochondria:

Limit screen time at night

Use blue light filters or glasses

Support mitochondrial resilience with targeted nutrients like CoQ10, PQQ, NAD⁺ precursors

Your mitochondria don’t just fuel your day — they fuel your longevity. ⚡

12/09/2025

Just giving away knowledge, experience and protocols I wish I had years ago—at no cost. Remember: this is not medical advice.

04/09/2025

Chakai (茶会): my sacred pause

Between consults, micro-adjustments, and high-stakes decisions, many days I’m in “OR mode”—alert, precise, demanding. I’ll admit it: because I’m obsessed with giving 100% to my work and my patients, I often neglect my own stress management. That’s exactly why chakai has become my favorite moment of the day.

Chakai—a simple tea gathering—reminds me of four pillars that sustain my practice in aesthetic, regenerative, and longevity medicine:

Radical presence. Preparing and drinking matcha slowly anchors me to the now: one breath, one intention, one sip.

Calm focus. Matcha’s L-theanine balances caffeine, giving smooth alertness for clearer thinking and better decisions.

Ritual & meaning. Ichigo-ichie: this moment won’t return. That awareness softens my energy before I step back into the clinic—making me a better physician and a better human.

Wabi-sabi. The humble bowl, the light, the silence—embracing simplicity and imperfection invites the parasympathetic “brake.”

It’s not just tea; it’s nervous-system hygiene—a daily micro-training to sustain excellence without burning out.
If you work under pressure, create your own ritual of presence. Your mind, your body, and your patients will notice. 🍵🍃

29/08/2025

22/07/2025

TÉ MATCHA 🍵✅ Por estas razones lo tomo cada día / MATCHA TEA 🍵✅For these reasons I have one every day ⬇️⬇️⬇️⬇️⬇️⬇️

🇬🇧 Benefits of matcha green tea 🍵:

• Protects mitochondria & DNA. 🛡️
• Reduces ROS.🔥
• Reduces AGEs.🚫
• Activates AMPK, FOXO & SIRT1 the stress-resistant proteins. 💪🏻
• Decreases TNF-α, IL-6 y CRP, biomarkers of chronic inflammation 💥
• Reduces LDL-C, fasting blood sugar & aids in wight loss.
• Helps the liver clear out toxins thanks to its high chlorophyl content.
• Reduces B-amyloid aggregation, a marker related to AD.

📖 PMID: 16582024; PMID: 19625741; PMID: 17655876; PMID: 15640470; PMID: 16469999.

🇪🇸 Beneficios del té verde matcha 🍵:

• Protege mitocondrias y ADN. 🛡️
• Reduce especies reactivas de oxígeno (ROS). 🔥
• Disminuye los productos de glicación avanzada (AGEs). 🚫
• Activa AMPK, FOXO y SIRT1, proteínas asociadas a la resistencia celular. 💪🏻
• Disminuye TNF-α, IL-6 y PCR, marcadores de inflamación crónica. 💥
• Reduce el colesterol LDL, la glucemia en ayunas y favorece la pérdida de peso.
• Ayuda al hígado a eliminar toxinas gracias a su alto contenido en clorofila.
• Disminuye la agregación de beta-amiloide, relacionada con el Alzheimer.

📖 PMID: 16582024; PMID: 19625741; PMID: 17655876; PMID: 15640470; PMID: 16469999.