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30/10/2023

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10/05/2022

The gastrointestinal tractTrusted Source contains many microorganisms, all of which can impact our digestive health and overall health. For example, our gut flora helps us in the following ways:

Maintaining the body’s immune function
Maintaining a healthy metabolism
Protecting against harmful pathogens
When the gut bacteria changes, it can lead to many health problems, such as developing infections or problems with inflammation.

When the bacteria in the gut become depleted or harmed, one treatment mode is via f***l transplant. F***l transplants are procedures when a doctor inserts f***s from a donor with healthy gut flora into the colon of the person with abnormal gut flora. These transplants can help to regulate and improve gut microorganisms.

However, the uses of f***l transplants might reach farther than researchers currently understand.

Transferring gut bacteria
The study examined the impact of f***l microbiota transfer (FMT) on aging using mice.

The mice were divided into three age groups:

Three months (young)
18 months (old)
24 months (aged)
Researchers first depleted the gut microbiota of the mice who received the f***l transfers by giving them broad-spectrum antibiotics. They gave the young mice f***l transfers from older mice and older mice transfers from young mice. They compared these groups with each other and with control groups that either received a transfer from mice their own age or no f***l transfer.

The researchers then performed behavioral testing to evaluate the mice’s brain functioning. They also conducted tests on brain tissue and used a variety of other methods to observe and study the changes in the mice after having f***l transfers.

They found that younger mice who received f***l transfers from aged mice had increased inflammation in their central nervous system and eyes. They also had increased permeability (leaky gut) in the intestine. These findings didn’t hold when the transfer was from old, rather than aged, mice.

The researchers saw an improvement in these areas when they face older mice f***l transfers from younger mice. However, their results did not indicate improved memory function.

Study author Dr. Aimee Parker explained their findings to Medical News Today:
These results show that gut microbes have an important role in regulating inflammation associated with deteriorating vision and brain function, at least in mice.”

She said the findings suggest that scientists may be “able to manipulate our gut microbes to help maintain good vision and good brain health for longer in old age.”

10/05/2022

To understand why dementia rates may decrease over time in Japan, MNT spoke with Dr. Hideki Hashimoto, DPH, a professor at the Department of Health and Social Behavior at the University of Tokyo, and a co-author of the study.

Dr. Hashimoto said that increasing educational attainment might be an important factor in explaining reduced dementia rates overall. He noted that, by 2035, over 60% of men would be college graduates. Meanwhile, in 2016, just 43% of men ages 55- 64 were college-educated.

He added that an Organization for Economic Co-operation and Development (OECD) Adult Skills Survey published in 2013 found that those with high school diplomas in Japan have more work-relevant skills than college graduates in Europe and the US.

Dr. Hashimoto thus concludes that the ‘unique educational background change’ is likely a major contributor to his model’s results.

Preventing dementia
When asked how these results could inform other countries concerning dementia in an aging population, Dr. Kaiser told MNT that the findings highlight public health planning efforts to address modifiable risk factors across the lifespan.

“Experts believe that something on the order of 1 out of 3 cases of dementia could be prevented through addressing twelve “modifiable risk factors” for dementia (low education, hypertension, hearing impairment, smoking, midlife obesity, depression, physical inactivity, diabetes, social isolation, excessive alcohol consumption, head injury, and air pollution),” he explained.

“Likewise, along with population-level efforts to prevent dementia, a focus on early detection for earlier intervention could significantly mitigate the impact and extend healthy years. One of the greatest myths about Alzheimer’s disease (or other types of dementia) is that there’s “nothing we can do. [But there’s] nothing could be further from the truth,” he said.

“The wide range of modifiable risk factors noted, and even our relationships or levels of loneliness, can be addressed as part of a multimodal strategy in people with early cognitive changes that may delay the onset or severity of dementia symptoms,” he added.

08/05/2022

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27/04/2022

Older adults tend to engage more in helping behaviors and are more satisfied with their lives than younger people.
The brain chemical oxytocin is associated with empathy and helping behaviors, and changes in oxytocin levels could explain these age-related changes.
A new study shows that older people show a larger increase in oxytocin levels in response to situations that evoke an emotional response than younger individuals.
This larger oxytocin response may explain why older individuals are more satisfied with life and engage in more helping behaviors.
A new study published in the journal Frontier in Behavioral Neuroscience shows that older individuals tend to release more oxytocin in response to social situations that arouse empathy. A larger oxytocin response was also associated with greater levels of helping behaviors and increased satisfaction with life.

These findings may explain why older individuals donate more to charity and perform more social work.

“People who released the most oxytocin in the experiment were not only more generous to charity but also performed many other helping behaviors. This is the first time a distinct change in oxytocin has been related to past prosocial behaviors,” said Dr. Paul Zak, the study author and a professor at Claremont Graduate University.

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