Skin disease management and cosmetics

Skin disease management and cosmetics cosmetic, any of several preparations (excluding soap) that are applied to the human body for beautifying, preserving, or altering the appearance or for ..

Though the legal definition of cosmetics in most countries is broader, in some Western countries, cosmetics are commonly taken to mean only makeup products, such as lipstick, mascara, eye shadow, foundation, blush, highlighter, bronzer, and several other product types. In the United States, the Food and Drug Administration (FDA), which regulates cosmetics,[4] defines cosmetics as products "intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions". This broad definition includes any material intended for use as an ingredient of a cosmetic product, with the FDA specifically excluding pure soap from this category
Cosmetics designed for skin care can be used to cleanse, exfoliate and protect the skin, as well as replenishing it, through the use of cleansers, toners, serums, moisturizers, and balms. Cosmetics designed for more general personal care, such as shampoo and body wash, can be used to cleanse the body. Cosmetics designed to enhance one's appearance (makeup) can be used to conceal blemishes, enhance one's natural features (such as the eyebrows and eyelashes), add color to a person's face and—in the case of more extreme forms of makeup used for performances, fashion shows and people in costume—can be used to change the appearance of the face entirely to resemble a different person, creature or object. Techniques for changing appearance include contouring, which aims to give shape to an area of the face. Cosmetics can also be designed to add fragrance to the body. Cosmetics have been in use for thousands of years, with ancient Egyptians and Sumerians using them. In the Europe, use of cosmetics continued into the Middle Ages—where the face was whitened and the cheeks rouged—[6] though attitudes towards cosmetics varied throughout time, with the use of cosmetics being openly frowned upon at many points in Western history.[7] Regardless of the changes in social attitudes towards cosmetics, ideals of appearance were occasionally achieved through the use of cosmetics by many. According to one source, early major developments in cosmetics include:[1]

Kohl used by ancient Egyptians
Castor oil also used in ancient Egypt as a protective balm
Skin creams made of beeswax, olive oil, and rose water, described by the Romans
Vaseline and lanolin in the nineteenth century. Historically, the absence of regulation of the manufacture and use of cosmetics, as well as the absence of scientific knowledge regarding the effects of various compounds on the human body for much of this time period, led to a number of negative adverse effects upon those who used cosmetics, including deformities, blindness and in some cases death. Many cosmetic products available at this time were still either chemically dubious or derived from natural resources commonly found in the kitchen, such as food colouring, berries and beetroot. Examples of the prevalent usage of harmful cosmetics include the use of ceruse (white lead) throughout a number of different cultures, such as during the Renaissance in the West, and blindness caused by the mascara Lash Lure during the early 20th century. During the 19th century, there was a high number of incidences of lead poisoning due to the fashion for red and white lead makeup and powder, leading to swelling and inflammation of the eyes, weakened tooth enamel and blackening skin, with heavy use known to lead to death. Usage of white lead was not confined only to the West, with the white Japanese face makeup known as oshiroi also produced using white lead. However, in the second part of the 19th century, scientific advances in the production of makeup lead to the creation of makeup free of hazardous substances such as lead.[citation needed]

Throughout the later 19th century and early 20th century, changes in the prevailing attitudes towards cosmetics led to the wider expansion of the cosmetics industry, with the market developed in the US during the 1910s by figures such as Elizabeth Arden, Helena Rubinstein, and Max Factor. These firms were joined by Revlon just before World War II and Estée Lauder just after. By the middle of the 20th century, cosmetics were in widespread use by women in nearly all industrial societies around the world, with the cosmetics industry becoming a multibillion-dollar enterprise by the beginning of the 21st century.[citation needed] The wider acceptance of the use of cosmetics, however, led some to come to see makeup as a tool utilised in the oppression and subjection of women to unfair societal standards. In 1968 at the feminist Miss America protest, protestors symbolically threw a number of feminine products into a "Freedom Trash Can",[8] with cosmetics among the items the protestors called "instruments of female torture"[9] and accoutrements of what they perceived to be enforced femininity. As of 2016, the world's largest cosmetics company is L'Oréal, founded by Eugène Schueller in 1909 as the French Harmless Hair Colouring Company (now owned by Liliane Bettencourt 26% and Nestlé 28%; the remaining 46% is traded publicly). Although modern makeup has been traditionally used mainly by women, an increasing number of men are using cosmetics usually associated with women to enhance or cover their own facial features such as blemishes and dark circles, as well the use of eyeshadow, mascara and lipstick by some. Cosmetics brands have increasingly also targeted men in the sale of cosmetics, with some products targeted specifically at men.

20/07/2023
30/05/2023

Cosmetics and personal care product

The use of cosmetics can be stated as a double-edged sword. This is because the purpose of using cosmetics is to enable ...
30/05/2023

The use of cosmetics can be stated as a double-edged sword. This is because the purpose of using cosmetics is to enable the skin to function correctly and to support its homeostasis to maintain beautiful, healthy, and glowing skin. However, on the other side, some of the ingredients in these cosmetics are found to be detrimental to the skin and may lead to skin diseases.

19/07/2022

the adverse effects associated with the use of antihistamines. It illustrates the implications of H1 receptor antagonists. Because attention has been focused upon over dosage, there are a number of newer reports about this problem, clearly showing that stimulation of the central nervous system and atropine-like symptoms occur as prominently as sedation. In children, the symptoms of stimulation dominate the clinical picture, in adults the sedation. Drowsiness being the most frequent side effect hampering the daytime use of the antihistamines, there is a continuing search for derivatives with little or no sedative effect. Often, initial clinical reports seem favorable but subsequently it always becomes evident that there is little or no difference on this score between any of the modem group of antihistamines. The chapter highlights the implications of individual products separately.

Cosmeceuticals represent a new category of products placed between cosmetics and pharmaceuticals that are intended for t...
15/07/2022

Cosmeceuticals represent a new category of products placed between cosmetics and pharmaceuticals that are intended for the enhancement of both the health and beauty of skin. Encompassing an ever-increasing part of the skin care industry, cosmeceuticals are formulated from a multitude of ingredients, the main categories of which are discussed in this article. Given the growing interest in these products among patients and the strong claims made by manufacturers, it is important that physicians recognize these agents and understand their benefits, limitations, and potential adverse effects.

Cosmetic chemicals interactiveSELECT THE BEAUTY PRODUCTS YOU USE BELOW AND FIND OUT HOW MANY CHEMICALS THEY CONTAIN!What...
24/06/2022

Cosmetic chemicals interactive
SELECT THE BEAUTY PRODUCTS YOU USE BELOW AND FIND OUT HOW MANY CHEMICALS THEY CONTAIN!
What is a cosmetic?
In Australia, a cosmetic is defined under the Industrial Chemical (Notification and Assessment) Act 1989 as ‘a substance or preparation intended for placement in contact with any external part of the human body' (this includes the mouth and teeth). We use cosmetics to cleanse, perfume, protect and change the appearance of our bodies or to alter its odours. In contrast, products that claim to ‘modify a bodily process or prevent, diagnose, cure or alleviate any disease, ailment or defect’ are called therapeutics. This distinction means that shampoos and deodorants are placed in the cosmetics category, whilst anti-dandruff shampoos and antiperspirants are considered to be therapeutics.
Regulation and safety
In Australia, the importation, manufacture and use of chemicals—including those used in cosmetics—are regulated by the Australian Government’s National Industrial Chemicals Notification and Assessment Scheme (NICNAS). NICNAS works to ensure that chemicals used in consumer products do not cause significant harm to users or to the environment.
In the case of cosmetics, every ingredient contained within the product must be scientifically assessed and approved by NICNAS before being manufactured or imported into Australia and before they can be used in consumer products. Where appropriate, NICNAS sets limits on the level at which a chemical can be used in a product and also conducts reviews on chemicals when new evidence arises.
Cosmetic products that make an additional therapeutic claim (such as moisturisers that also lighten the skin) are regulated by a different organisation—the Therapeutic Goods Administration (TGA).
Cosmetics and other personal care items must also be labelled in accordance with the Trade Practices (Consumer Product Information Standards, Cosmetics) Regulations 1991. This regulation requires that all intentionally added ingredients are listed on the product label, and is enforced by the Australian Competition and Consumer Commission (ACCC).

Various tools are used to apply cosmetics.BrushesA makeup brush is used to apply makeup onto the face. There are two typ...
07/09/2021

Various tools are used to apply cosmetics.

Brushes
A makeup brush is used to apply makeup onto the face. There are two types of makeup brushes: synthetic and natural. Synthetic brushes are best for cream products while natural brushes are ideal for powder products.[20] Using the appropriate brush to apply a certain product allows the product to blend into the skin smoothly and evenly.
A foundation brush is usually a dense brush that distributes the product evenly while smoothing out the face. This brush is best used to achieve full coverage.
A concealer brush has a small, tapered tip that allows for precise spot correction such as blemishes or discoloration.
A stippling brush has soft, synthetic bristles that gives an airbrushed effect. This brush is best used to achieve light to medium coverage.
A blush brush comes in all shapes and sizes and is used to apply blush, allowing the blush to look natural while giving a flush of color.
A powder brush tends to be big and fluffy for quick and easy application of dusting powder all over the face. Powder gives the appearance of a matte effect.
A bronzer blush, which can also serve as a contour brush is an angled brush that gives the face dimensions and illusions, by allowing the makeup to be placed in substitution of bone structure. This brush can also be used to add a shimmering highlight illusion to the cheekbones, nose and chin.
A highlight brush, also known as a fan brush, has bristles that are typically spread out and is used to apply where the sun would naturally hit.
An eyeshadow brush is a dense brush that allows shadow to be packed onto the eyelid.
A blending eyeshadow brush is used to blend out any harsh lines you may have from the eyeshadow and can soften the eyeshadow look.
An eyeliner brush is tapered with an extra fine tip used for gel eyeliners which allows precision to line the eyes.
A spoolie is used to brush out the eyebrows and can also be used as a mascara wand.
A lip brush is small to ensure precision and is used to apply lipstick evenly onto the lips.
An eyebrow brush is tapered and is slanting from the top, which tends to define the eyebrows and fill in the empty spaces between brows, to give them a fuller and denser look.
A Kabuki brush is used to apply any sort of powder makeup on large surfaces of the face (loose powder, foundation, face powder, blush, bronzer). This brush is used to evenly the skin.
Other applicators
In addition to brushes, a makeup sponge is a popular applicator. Makeup sponges can be used to apply foundation, blend concealer, and apply powder or highlighter.

Loofahs, microfiber cloths, natural sponges, or brushes may be used to exfoliate skin, simply by rubbing them over the face in a circular motion. Gels, creams, or lotions may contain an acid to encourage dead skin cells to loosen, and an abrasive such as microbeads, sea salt and sugar, ground nut shells, rice bran, or ground apricot kernels to scrub the dead cells off the skin. Salt and sugar scrubs tend to be the harshest, while scrubs containing beads or rice bran are typically very gentle.

Ingredients
Main article: Ingredients of cosmetics
A variety of organic compounds and inorganic compounds comprise typical cosmetics. Typical organic compounds are modified natural oils and fats as well as a variety of petrochemically derived agents. Inorganic compounds are processed minerals such as iron oxides, talc, and zinc oxide. The oxides of zinc and iron are classified as pigments, i.e. colorants that have no solubility in solvents.

Natural
See also: Organic movement and Maker culture
Handmade and certified organic products are becoming more mainstream, due to the fact that certain chemicals in some skincare products may be harmful if absorbed through the skin. Products claimed to be organic should, in the U.S., be certified "USDA Organic".[21] One of the most popular traditional Chinese medicines is the fungus tremella fuciformis, used as a beauty product by women in China and Japan.[22]

Mineral
The term "mineral makeup" applies to a category of face makeup, including foundation, eye shadow, blush, and bronzer, made with loose, dry mineral powders. These powders are often mixed with oil-water emulsions. Lipsticks, liquid foundations, and other liquid cosmetics, as well as compressed makeups such as eye shadow and blush in compacts, are often called mineral makeup if they have the same primary ingredients as dry mineral makeups. However, liquid makeups must contain preservatives and compressed makeups must contain binders, which dry mineral makeups do not. Mineral makeup usually does not contain synthetic fragrances, preservatives, parabens, mineral oil, and chemical dyes. For this reason, dermatologists may consider mineral makeup to be gentler to the skin than makeup that contains those ingredients.[23] Some minerals are nacreous or pearlescent, giving the skin a shining or sparking appearance. One example is bismuth oxychloride.[1] There are various mineral-based makeup brands, including: Bare Minerals, Tarte, Bobbi Brown, and Stila.

Porous minerals
Porous minerals is a subcategory of mineral makeup ingredients where the porosity of the mineral particles enables extraordinary absorption capacity compared to non-porous mineral materials. This feature improves sebum control, long-lasting mattifying effect or gives a matte texture when used in makeup. Porous minerals can also act as carriers, absorbing a wide range of substances into its porous network.

Advertised benefits of mineral-based makeup
Although some ingredients in cosmetics may cause concerns, some are seen as beneficial. Titanium dioxide, found in sunscreens, and zinc oxide have anti-inflammatory properties.[24] Many mineral based makeup create a barrier between the skin and outside elements, which allows it to provide some protection against the sun and its possible harmful effects.[25]

Mineral makeup is noncomedogenic (as long as it does not contain talc) and offers a mild amount of sun protection (because of the titanium dioxide and zinc oxide).[citation needed]

Cosmetic packaging
Main article: Cosmetic packaging
The term cosmetic packaging is used for primary packaging and secondary packaging of cosmetic products.[citation needed]

Primary packaging, also called cosmetic container, is housing the cosmetic product. It is in direct contact with the cosmetic product. Secondary packaging is the outer wrapping of one or several cosmetic container(s). An important difference between primary and secondary packaging is that any information that is necessary to clarify the safety of the product must appear on the primary package. Otherwise, much of the required information can appear on just the secondary packaging.[26]

Cosmetic packaging is standardized by the ISO 22715, set by the International Organization for Standardization[citation needed][27] and regulated by national or regional regulations such as those issued by the EU or the FDA. Marketers and manufacturers of cosmetic products must be compliant to these regulations to be able to market their cosmetic products in the corresponding areas of jurisdiction.[citation needed]

Industry

Cosmetics at department store Farmers Centre Place in Hamilton, New Zealand
The manufacture of cosmetics is dominated by a small number of multinational corporations that originated in the early 20th century, but the distribution and sales of cosmetics is spread among a wide range of businesses. The world's largest cosmetic companies are L'Oréal, Procter & Gamble, Unilever, Shiseido, and Estée Lauder.[28] In 2005, the market volume of the cosmetics industry in the US, Europe, and Japan was about EUR 70 Billion/a year.[1] In Germany, the cosmetic industry generated €12.6 billion of retail sales in 2008,[29] which makes the German cosmetic industry the third largest in the world, after Japan and the United States. German exports of cosmetics reached €5.8 billion in 2008, whereas imports of cosmetics totaled €3 billion.[29]

The worldwide cosmetics and perfume industry currently generates an estimated annual turnover of US$170 billion (according to Eurostaf – May 2007). Europe is the leading market, representing approximately €63 billion, while sales in France reached €6.5 billion in 2006, according to FIPAR (Fédération des Industries de la Parfumerie – the French federation for the perfume industry).[30][unreliable source?] France is another country in which the cosmetic industry plays an important role, both nationally and internationally. According to data from 2008, the cosmetic industry has grown constantly in France for 40 consecutive years. In 2006, this industrial sector reached a record level of €6.5 billion. Famous cosmetic brands produced in France include Vichy, Yves Saint Laurent, Yves Rocher, and many others.

Cosmetics at Life Pharmacy at Westfield Albany on the North Shore of Auckland, New Zealand
The Italian cosmetic industry is also an important player in the European cosmetic market. Although not as large as in other European countries, the cosmetic industry in Italy was estimated to reach €9 billion in 2007.[citation needed] The Italian cosmetic industry is dominated by hair and body products and not makeup as in many other European countries. In Italy, hair and body products make up approximately 30% of the cosmetic market. Makeup and facial care, however, are the most common cosmetic products exported to the United States.

According to Euromonitor International, the market for cosmetics in China is expected to be $7.4 billion in 2021 up from $4.3 billion in 2016. The increase is due to social media and the changing attitudes of people in the 18-to-30-year age bracket.[31]

Due to the popularity of cosmetics, especially fragrances and perfumes, many designers who are not necessarily involved in the cosmetic industry came up with perfumes carrying their names. Moreover, some actors and singers (such as Celine Dion) have their own perfume line. Designer perfumes are, like any other designer products, the most expensive in the industry as the consumer pays for the product and the brand. Famous Italian fragrances are produced by Giorgio Armani, Dolce & Gabbana, and others.

Procter & Gamble, which sells CoverGirl and Dolce & Gabbana makeup, funded a study[32] concluding that makeup makes women seem more competent.[33] Due to the source of funding, the quality of this Boston University study is questioned.

Cosmetics products may be retailed in beauty stores, department stores and hypermarkets, drugstores, variety stores, grocery stores, beauty supply stores, and many other formats, and in similar types of online stores or the online presence of these types of physical stores.

Controversy
Further information: Environmental impact of pharmaceuticals and personal care products
During the 20th century, the popularity of cosmetics increased rapidly.[34] Cosmetics are used by girls at increasingly young ages, especially in the United States. Because of the fast-decreasing age of makeup users, many companies, from high-street brands like Rimmel to higher-end products like Estee Lauder, cater to this expanding market by introducing flavored lipsticks and glosses, cosmetics packaged in glittery and sparkly packaging, and marketing and advertising using young models.[35] The social consequences of younger and younger cosmetics use has had much attention in the media over the last few years.

Criticism of cosmetics has come from a wide variety of sources including some feminists,[36] religious groups, animal rights activists, authors, and public interest groups. It has also faced criticism from men, some of whom describe it as a form of deception or fakeup.[37]

Safety
In the United States: "Under the law, cosmetic products and ingredients do not need FDA premarket approval."[38] The EU and other regulatory agencies around the world have more stringent regulations.[39] The FDA does not have to approve or review cosmetics, or what goes in them, before they are sold to the consumers. The FDA only regulates against some colors that can be used in the cosmetics and hair dyes. The cosmetic companies do not have to report any injuries from the products; they also only have voluntary recalls of products.[4]

There has been a marketing trend towards the sale of cosmetics lacking controversial ingredients, especially those derived from petroleum, sodium lauryl sulfate (SLS), and parabens.[40] Per- and polyfluoroalkyl substances (PFAS) are a class of about 9,000 synthetic organofluorine compounds that have multiple highly toxic fluorine atoms attached to an alkyl chain. PFAS are used by major cosmetics industry companies in a wide range of cosmetics, including such products as lipstick, eye liner, mascara, foundation, concealer, lip balm, blush, nail polish. A 2021 study tested 231 personal care products and found organic fluorine, a hallmark of PFAS, in more than half of the samples. Substantial levels of fluorine were identified in tested brands of products as follows: 82% of the brands of waterproof mascara, 63% of the brands of foundations, and 62% of liquid lipstick. PFAS compounds are readily absorbed through human skin and through tear ducts, and such products on lips are often unwittingly ingested. Manufacturers often fail to label their products as containing PFAS, which makes it difficult for cosmetics consumers to avoid products containing PFAS.[41]

Formaldehyde is no longer used in cosmetics but has been replaced by formaldehyde releasers. Formaldehyde is dangerous to human health.[42][43] In 2011, the US National Toxicology Program described formaldehyde as "known to be a human carcinogen".[44][45][46]

The danger of formaldehyde is a major reason for the development of formaldehyde releasers which release formaldehyde slowly at lower levels.[47]

Numerous reports have raised concern over the safety of a few surfactants, including 2-butoxyethanol. In some individuals, SLS may cause a number of skin problems, including dermatitis. Additionally, some individuals have had an emergence of vitiliago after using cosmetics containing the ingredient rhododendrol.[48][49][50][51][52][53]

Parabens can cause skin irritation and contact dermatitis in individuals with paraben allergies, a small percentage of the general population.[54] Animal experiments have shown that parabens have a weak estrogenic activity, acting as xenoestrogens.[55]

Patch test
Perfumes are widely used in consumer products. Studies concluded from patch testing show fragrances contain some ingredients which may cause allergic reactions.[56]

Balsam of Peru was the main recommended marker for perfume allergy before 1977, which is still advised. The presence of Balsam of Peru in a cosmetic will be denoted by the INCI term Myroxylon pereirae.[57][58] In some instances, Balsam of Peru is listed on the ingredient label of a product by one of its various names, but it may not be required to be listed by its name by mandatory labeling conventions (in fragrances, for example, it may simply be covered by an ingredient listing of "fragrance").[58][59][60][61]

Some cosmetics companies have made pseudo-scientific claims about their products which are misleading or unsupported by scientific evidence.[62][63]

Animal testing
Ambox current red.svg
This section needs to be updated. Please help update this article to reflect recent events or newly available information. (September 2016)
Main article: Testing cosmetics on animals
As of 2019 an estimated 50-100 million animals are tested on each year in locations such as the United States and China.[64] Such tests have involved general toxicity, eye and skin irritants, phototoxicity (toxicity triggered by ultraviolet light), and mutagenicity.[65][66] Due to the ethical concerns around animal testing, some nations have legislated against animal testing for cosmetics. An updated list can be found on the Humane Societies website.[67] According to the Humane Society of the United States, there are nearly 50 non-animal tests that have been validated for use, with many more in development, that may replace animal testing and are potentially more efficacious.[68] In the United States, mice, rats, rabbits, and cats are the most used animals for testing.[69] In 2018, California banned the sale of animal tested cosmetics.[70]

Cosmetics testing is banned in the Netherlands, India, Norway, Israel, New Zealand, Belgium, and the UK, and in 2002, the European Union agreed to phase in a near-total ban on the sale of animal-tested cosmetics throughout the EU from 2009, and to ban all cosmetics-related animal testing.[71] In December 2009, the European Parliament and Council passed the EC Regulation 1223/2009 on cosmetics, a bill to regulate the cosmetic industry in the EU.[72] EC Regulation 1223/2009 took effect on July 11, 2013.[72] In March 2013, the EU banned the import and sale of cosmetics containing ingredients tested on animals.[73] China required animal testing on cosmetic products until 2014, when they waived animal testing requirements for domestically produced products.[74] In 2019, China approved nine non-animal testing methods, and announced that by 2020 laws making animal testing compulsory would be lifted.[75]

In June 2017, legislation was proposed in Australia to end animal testing in the cosmetics industry.[76] In March 2019, the Australian Senate passed a bill banning the use of data from animal testing in the cosmetic industry after July 1, 2020.[77]

Legislation
Europe
In the European Union, the manufacture, labelling, and supply of cosmetics and personal care products are regulated by Regulation EC 1223/2009.[78] It applies to all the countries of the EU as well as Iceland, Norway, and Switzerland. This regulation applies to single-person companies making or importing just one product as well as to large multinationals. Manufacturers and importers of cosmetic products must comply with the applicable regulations in order to sell their products in the EU. In this industry, it is common fall back on a suitably qualified person, such as an independent third party inspection and testing company, to verify the cosmetics' compliance with the requirements of applicable cosmetic regulations and other relevant legislation, including REACH, GMP, hazardous substances, etc.[79][80]

In the European Union, the circulation of cosmetic products and their safety has been a subject of legislation since 1976. One of the newest improvement of the regulation concerning cosmetic industry is a result of the ban animal testing. Testing cosmetic products on animals has been illegal in the European Union since September 2004, and testing the separate ingredients of such products on animals is also prohibited by law, since March 2009 for some endpoints and full since 2013.[81]

Cosmetic regulations in Europe are often updated to follow the trends of innovations and new technologies while ensuring product safety. For instance, all annexes of the Regulation 1223/2009 were aimed to address potential risks to human health. Under the EU cosmetic regulation, manufacturers, retailers, and importers of cosmetics in Europe will be designated as "Responsible Person".[82] This new status implies that the responsible person has the legal liability to ensure that the cosmetics and brands they manufacture or sell comply with the current cosmetic regulations and norms. The responsible person is also responsible of the documents contained in the Product Information File (PIF), a list of product information including data such as Cosmetic Product Safety Report, product description, GMP statement, or product function.

United States
In 1938, the U.S. passed the Food, Drug, and Cosmetic Act authorizing the Food and Drug Administration (FDA) to oversee safety via legislation in the cosmetic industry and its aspects in the United States.[83][84] The FDA joined with 13 other federal agencies in forming the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) in 1997, which is an attempt to ban animal testing and find other methods to test cosmetic products.[85]

The current law on cosmetics in the USA do not require cosmetic products and ingredients to have FDA approval before going on the market except from color additives.[86] The Cosmetic Safety Enhancement Act was introduced in December 2019 by Representative Frank Pallone.[87]

Brazil
ANVISA (Agência Nacional de Vigilância Sanitária, Brazilian Health Surveillance Agency) is the regulatory body responsible for cosmetic legislation and directives in the country. The rules apply to manufacturers, importers, and retailers of cosmetics in Brazil, and most of them have been harmonized so they can apply to the entire Mercosur.

The current legislation restricts the use of certain substances such as pyrogallol, formaldehyde, or paraformaldehyde and bans the use of others such as lead acetate in cosmetic products. All restricted and forbidden substances and products are listed in the regulation RDC 16/11 and RDC 162, 09/11/01.

More recently, a new cosmetic Technical Regulation (RDC 15/2013) was set up to establish a list of authorized and restricted substances for cosmetic use, used in products such as hair dyes, nail hardeners, or used as product preservatives.

Most Brazilian regulations are optimized, harmonized, or adapted in order to be applicable and extended to the entire Mercosur economic zone.

International
The International Organization for Standardization (ISO) published new guidelines on the safe manufacturing of cosmetic products under a Good Manufacturing Practices (GMP) regime. Regulators in several countries and regions have adopted this standard, ISO 22716:2007, effectively replacing existing guidance and standards. ISO 22716 provides a comprehensive approach for a quality management system for those engaged in the manufacturing, packaging, testing, storage, and transportation of cosmetic end products. The standard deals with all aspects of the supply chain, from the early delivery of raw materials and components until the shipment of the final product to the consumer.

The standard is based on other quality management systems, ensuring smooth integration with such systems as ISO 9001 or the British Retail Consortium (BRC) standard for consumer products. Therefore, it combines the benefits of GMP, linking cosmetic product safety with overall business improvement tools that enable organisations to meet global consumer demand for cosmetic product safety certification.[88]

In July 2012, since microbial contamination is one of the greatest concerns regarding the quality of cosmetic products, the ISO has introduced a new standard for evaluating the antimicrobial protection of a cosmetic product by preservation efficacy testing and microbiological risk assessment.

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