14/11/2025
[AI generated]
🧬 What is Marburg Virus Disease (MVD)?
• Definition: A highly virulent disease in humans, formerly called Marburg hemorrhagic fever.
• Cause: Caused by two viruses in the Marburgvirus genus — Marburg virus (MARV) and Ravn virus (RAVV).
• Natural reservoir: The Egyptian fruit bat (Rousettus aegyptiacus) is considered the natural host.
⚠️ Symptoms
• Incubation period: 2–21 days after exposure.
• Early signs: Sudden fever, chills, headache, muscle aches, and weakness.
• Progression: Severe diarrhea, abdominal pain, nausea, and vomiting.
• Advanced stage: Hemorrhaging (internal and external bleeding), shock, multi-organ failure.
• Fatality rate: Historically ranges from 24% to 88%, with an average around 50%.
🔄 Transmission
• Animal-to-human: Initial spillover from fruit bats.
• Human-to-human: Direct contact with blood, secretions, or other bodily fluids of infected individuals.
• Healthcare risk: Nosocomial transmission is common without strict infection control.
🏥 Treatment & Prevention
• No approved vaccine or antiviral treatment yet.
• Supportive care: Rehydration, maintaining oxygen status, and treating specific symptoms improve survival.
• Experimental options: Several vaccines and therapies are under development.
• Prevention:• Avoid exposure to fruit bats and infected individuals.
• Strict infection control in healthcare settings.
• Community engagement is critical for outbreak containment.
🌍 Outbreaks
• First identified in 1967 in Germany and Yugoslavia among lab workers exposed to African green monkeys.
• Sporadic outbreaks have occurred in Africa (Uganda, Angola, Democratic Republic of Congo, Kenya, Tanzania).
• Recent outbreaks (2025) have drawn global attention, with WHO and CDC monitoring closely.
🔑 Key Takeaways
• Marburg virus disease is extremely dangerous and requires rapid public health response.
• Fatality rates are high, but supportive care can improve survival.
• No vaccine yet, but research is ongoing.
• Similar to Ebola, but caused by a different virus family.
Disclaimer: This is AI generated content.