16/10/2025
🔬 InPress: Real-World Insights Into Generalized Pustular Psoriasis in Finland
Our new population-based study from , published in Skin Health and Disease, sheds light on characteristics of patients with generalized pustular psoriasis (GPP), a rare chronic and potentially life-threatening inflammatory skin disease. Using national registry data (1996–2021), we evaluated epidemiology, comorbidities, treatments, flare occurrence, risk factors for flares, and overall survival compared to matched population-based controls and controls with psoriasis vulgaris (PV).
🔍 Key findings:
⚫ GPP prevalence and incidence estimates were sensitive to criteria used in identification: prelavence decreased from 9.9 to 4.7 per 100,000, and incidence from 4.2 to 2.1 per 100,000 with stricter case criteria.
⚫ Several comorbidities evaluated were more common in GPP compared not only to population-based control group but also to PV.
⚫ Overall survival was significantly lower in patients with GPP versus controls.
⚫ 43% experienced flares during follow-up, of which one-third (33%) had a flare at the time of first GPP diagnosis.
⚫ Systemic corticosteroid use increased the risk of flares
⚫ Flares were associated with a higher risk of death.
💡 These findings underscore the high disease burden of GPP and shorter survival and highlight the urgent need for standardized guidelines to improve timely diagnosis and management.
📖 Read the full article here: https://doi.org/10.1093/skinhd/vzaf076
📚 Read more of our studies: https://www.medengine.fi/publications/
🤝 This study was a collaboration by researchers from , Boehringer Ingelheim, Tampere University Hospital, Helsinki University Central Hospital and Oulu University Hospital.
