Medicortex Finland Oyj

04/11/2025

Genetic Damage Discovered in Brain Cells of Chronic Traumatic Encephalopathy Patients

Repeated head impacts in contact sports such as American football, ice hockey, and boxing have long been associated with Chronic Traumatic Encephalopathy (CTE), a progressive neurodegenerative disease characterized by changes in mood, memory, behavior, and cognition.

A recent study published in Science¹ has now shown that neurons from individuals with CTE exhibit significant genomic damage, similar to that observed in Alzheimer’s disease. This finding highlights a newly discovered molecular similarity between the two conditions, in addition to the well-known accumulation of tau protein in the brain.

The risk of developing CTE increases with each additional year of exposure to repetitive head impacts, and evidence suggests that both genetic damage and tau buildup may begin years before symptoms appear. Unfortunately, CTE can still only be definitively diagnosed post-mortem; there is currently no blood test or imaging tool capable of detecting the disease in living patients. However, growing evidence shows that cellular and molecular changes occur long before clinical symptoms, underscoring the urgent need for rapid, point-of-injury diagnostics.

Medicortex Finland (www.medicortex.fi) is addressing this challenge by developing a portable, non-invasive diagnostic test capable of detecting concussion biomarkers immediately after a head impact whether on the playing field, in the boxing ring, or on the battlefield. Early detection offers the potential to prevent cumulative brain damage and reduce the risk of long-term neurodegeneration.

Reference

1 D**g et al., Diverse somatic genomic alterations in single neurons in chronic traumatic encephalopathy. Science, 30 October 2025 Vol 390, Issue 6772

16/10/2025

Medicortex is pleased to announce the publication of our mini review article on glymphatic function after mild TBI. This is an important merit supporting the company's initiative to expand its research areas of interest.

Since the discovery of the glymphatic system in 2012, research on this brain-wide fluid exchange pathway has focused on understanding its role in different n...

13/10/2025

Blast-related traumatic brain injuries on the battlefield

Traumatic brain injury (TBI) is a leading cause of morbidity among military personnel. Unlike civilian cases, battlefield TBIs often result from blast exposures. In addition, military personnel face a higher risk of penetrating brain injuries.

While penetrating TBIs are usually identified and treated immediately, mild TBIs (mTBI)—also known as concussions—are frequently overlooked, especially when other serious injuries are present. Early detection of mTBI is essential for effective treatment and better long-term outcomes.

Currently, there are no reliable tools to diagnose mTBI in combat settings. As a result, many soldiers with blast-related mTBIs—sometimes sustained years earlier—remain undiagnosed, with symptoms that persist or worsen over time.

When mTBI goes unnoticed, injured service members may return to duty too soon. This can impair performance and judgment, increasing the risk to themselves and others. Tasks such as driving or handling weapons may be affected, and the chance of sustaining additional TBIs also rises. To reduce these risks, any service member exposed to a blast, fall, or vehicle crash should be evaluated for brain injury, even in the absence of visible head trauma.

Medicortex Finland Plc is developing a rapid point-of-care test to detect mTBI. Designed for use on the battlefield, the test aims to quickly assess whether a soldier is fit to return to duty. Learn more at www.medicortex.fi

08/10/2025

Never Shake Your Baby!

When a baby won’t stop crying, a frustrated parent or caregiver might shake the baby—an action that can be extremely dangerous. Violent shaking can cause shaken baby syndrome (SBS), a serious traumatic brain injury that damages brain cells and cuts off oxygen. SBS is the leading cause of child abuse deaths, with up to 1,400 cases reported annually in the U.S.

Because babies have weak neck muscles and relatively large heads, they cannot yet support their head on their own. When shaken violently, their brains move back and forth inside the skull, causing bleeding, swelling, and bruising. Babies that survive this brain damage may develop neurological complications such as blindness, epilepsy, or developmental delays.

SBS is entirely preventable. Parents under stress should seek help from family, friends, or healthcare providers. Raising awareness and understanding risk factors—such as stress, alcohol use, or a history of abuse—can save lives.

Medicortex Finland Plc is developing a rapid, easy-to-use, diagnostic test for detecting traumatic brain injuries. For more information, please visit www.medicortex.fi.

(This is not intended as medical advice)

19/09/2025

שנה טובה !!!

18/09/2025

Partner Violence Can Cause Traumatic Brain Injury

Intimate partner violence (IPV) refers to violence that happens within a relationship. IPV affects approximately 1 in 3 women and 1 in 10 men, with women more often sustaining serious injuries. Many victims of IPV suffer from blunt force trauma to their face, which can lead to mild traumatic brain injury (TBI).

IPV is an underrecognized public health problem with an economic burden of $3.6 trillion in the USA. It is estimated that 75 % of female IPV survivors may have unrecognized and undiagnosed TBI. Symptoms of IPV-related TBI include memory loss, hearing and vision disturbances, concentration difficulties, and psychiatric problems.

Only about 20 % of women, who report an IPV-related head injury, receive TBI screening or medical care. When left untreated, these head injuries may lead to chronic health problems. Receiving the right treatment on time, increases the chance of recovery and survival from IPV-related injuries. Thus, it is important to raise awareness of IPV and TBI, help victims to navigate local health services, and increase the availability of screening and other diagnostic methods for TBI.

Medicortex Finland Plc is developing a rapid diagnostic test for TBI that can be used at the point-of-care or for self-testing. The test can be done in settings such as shelters or emergency clinics. For more information, please visit www.medicortex.fi

08/09/2025

Will you consider a small investment?

04/09/2025

Invest in concussion detection!

Medicortex Finland Oyj in Turku is developing an easy-to-use test to identify whether a blow to the head has caused a concussion. The rapid strip test detects markers of brain damage in urine or saliva.

Use: At home, sports teams’ and cars’ first aid kits, in ambulances, health centres, etc. A huge market worldwide because similar rapid tests are not yet in use, but the current testing method is CT or MRI imaging of the brain in a hospital.

Limited share issue: until 10.9.2025. Investments starting at 500 euros.
Contact us: +358 400 870 366 | medicortex@medicortex.fi | www.medicortex.fi

Please see more information here:

https://medicortex.fi/investors/

Medicortex has a fundraising campaign until 10th of September 2025. The company’s shares can be subscribed for the price of 1€ per share. The minimum investment is 500€.

29/08/2025

Turun Sanomat published an article about the new Israeli patent granted to Medicortex.

Turkulainen biolääkeyhtiö Medicortex kertoo saaneensa Israelissa patentin kehittämälleen menetelmälle ja laitteelle, joita on määrä käyttää aivovammojen diagnosointiin.

29/08/2025

The Challenge of Detecting TBI in Infants

Traumatic brain injury (TBI) or concussions are usually caused by a hit to the head as a result of a fall, sports injury or vehicle crash. In young children, the most common causes of TBI are falls and assault. TBI is the leading cause of disability and death in children ages 0-4 years. Infants and young children with brain injuries might not be able to communicate their symptoms, making diagnosis of TBI difficult.

Symptoms of TBI can vary depending on the extent and location of injury, but typically include headache, nausea/dizziness, sensory problems, and confusion. If there are no clear signs that the child has TBI, the caregiver should pay attention to changes in behavior such as eating, sleeping, or nursing habits, and unusual or easy irritability. The child may also struggle to pay attention, have a low mood, and they may lose interest in their favorite toys or activities.

It is important to notice these symptoms to get the right treatment for the child. TBI has a more severe impact on children, because their brain is still developing. This means that the functional deficits may not be immediately apparent after the injury, but they can create lifetime challenges for living and learning as the child gets older. Therefore, TBI in children is a chronic disease process rather than a one-time event. Children with TBI suffer particularly from impairments in their abilities to think, learn, and develop socially appropriate behaviors. With early diagnosis, the severity of symptoms may decrease.

Medicortex Finland Plc is developing a rapid, easy-to-use, diagnostic test to detect TBI. For more information, please visit: www.medicortex.fi

(This information is based on scientific literature but is not intended as medical advice)

28/08/2025

Medicortex was granted a patent in Israel for company’s innovative method and device for non-invasive detection of TBI.

Medicortex Finland Plc, a biopharmaceutical company focusing on development of diagnostics and drugs for mild traumatic brain injury (TBI), was granted a patent in Israel for company’s innovative method and device for non-invasive detection of TBI.

22/08/2025

זעזוע מוח הוא חבלת ראש טראומטית בעוצמה קלה עד בינונית, הנגרמת מפגיעה ישירה בראש או מתנועת האצה־האטה חדה (למשל בתאונה) שגורמת לרקמת המוח להכות בדופן הגולגולת.
בארה״ב מדווחים על כ־2.5 מיליון מקרי זעזוע מח בשנה, והמספר האמיתי גבוה הרבה יותר, וזאת בשל קושי באבחון.
גורמים עיקריים: נפילות, תאונות אופניים/קורקינט/אופנוע, ספורט אתגרי, תאונות עבודה, ארועי אלימות ופעילות צבאית.
תסמינים: חלקם מיידיים וחלקם מתפתחים בהמשך.
• מיידיים: אובדן הכרה קצר, בלבול, אובדן זיכרון, סחרחורת, כאבי ראש, בחילות והקאות.
• מאוחרים: שינויים במצב רוח, עייפות, איטיות בדיבור ותגובה, קשיי זיכרון, ירידה בקשב וריכוז, בעיות שינה.
אבחון: הערכה רפואית ראשונית, בדיקת נוירולוג לתפקוד קוגניטיבי ומוטורי, ולעיתים הדמיה (CT/MRI).
טיפול: מנוחה והימנעות מפעילות גופנית; במקרים חמורים – השגחה בבית חולים, ובמקרה של דימום מוחי – ניתוח נוירוכירורגי.
סיכונים: חבלות חוזרות, גם קלות, מגבירות סיכון למחלות נוירודגנרטיביות בגיל מבוגר (למשל אצל מתאגרפים ושחקני פוטבול).
מניעה: שימוש בקסדה בעת רכיבה על כל כלי דו־גלגלי.
חברת מדיקורטקס מפתחת ערכת גילוי על בסיס בדיקת שתן או רוק. ( WWW.MEDICORTEX.FI )

המידע הוא כללי ואינו מהווה ייעוץ רפואי, המידע הוא אישי ומבוסס ספרות בלבד