Intensive Care Medicine

Intensive Care Medicine The official page for ICM, Intensive Care Medicine.

ICM is an international peer-reviewed medical journal intended for all those who are involved in intensive care medicine. ''Intensive Care Medicine'' is the publication platform for the communication and exchange of current work and ideas in intensive care medicine. The journal publishes original research papers, reviews, as well as discussions on technology, methods, new apparatus and modifications of standard techniques and correspondence concerning matters of topical interest or relating to published material. Official journal of The European Society of Intensive Care Medicine and The European Society of Paediatric and Neonatal Intensive Care.
12 issues per year.

https://zurl.co/JNmB5 Driving pressure is plateau pressure minus total PEEP and equals tidal volume divided by respirato...
10/02/2026

https://zurl.co/JNmB5 Driving pressure is plateau pressure minus total PEEP and equals tidal volume divided by respiratory system compliance. Values above 14 cmH2O are associated with increased ARDS mortality and support tidal volume reduction if gas exchange remains acceptable. Transpulmonary pressure is airway pressure minus oesophageal pressure, and end-expiratory targets of 0–10 cmH2O improved oxygenation with a mortality trend not confirmed in EPVent-2.

https://zurl.co/UkcP7 Bundle-based sepsis protocols improve early recognition, antibiotics, fluids and vasopressors, yet...
10/02/2026

https://zurl.co/UkcP7 Bundle-based sepsis protocols improve early recognition, antibiotics, fluids and vasopressors, yet mortality gains have plateaued in many well-resourced settings. Biological heterogeneity spans immune suppression, endothelial injury and metabolic signatures, making trajectories such as mHLA-DR recovery clinically relevant. Bedside perfusion monitoring and biomarker-guided, shorter antibiotic courses support more individualised decisions.

https://zurl.co/7EXEF -Quizz In severe hemoptysis, intravenous terlipressin stabilised an elderly patient but induced...
09/02/2026

https://zurl.co/7EXEF -Quizz In severe hemoptysis, intravenous terlipressin stabilised an elderly patient but induced vasospasm that obscured culprit vessels, delaying bronchial artery embolisation and leading to rebleeding 48 hours later from previously unseen branches of the thyrocervical and internal mammary arteries. Chest CT showed no arterial involvement at 1 hour but marked hypervascularisation at 16 hours, supporting delayed imaging and extended ICU monitoring.

-Quizz An 83-year-old with atrial fibrillation and massive haemoptysis received inhaled tranexamic acid, intravenous ...
09/02/2026

-Quizz An 83-year-old with atrial fibrillation and massive haemoptysis received inhaled tranexamic acid, intravenous terlipressin, anticoagulation reversal and first bronchial artery embolisation of the right bronchial artery and intercostobronchial trunk. Chest CT angiography 16 hours apart (Panels A and B) shows an interval change at the red arrows. Considering the treatment sequence and timing, what happened between the two CT scans?

https://zurl.co/jiYzJ Nearly 40% of ICU survivors reported delusional memories three months after discharge. These memor...
08/02/2026

https://zurl.co/jiYzJ Nearly 40% of ICU survivors reported delusional memories three months after discharge. These memories were independently linked to a 3.5–5-fold rise in persistent PTSD symptoms at 12 months. Deep sedation was associated with more amnesia, but delusional memories had a higher long-term symptom burden.

https://zurl.co/rntIl Haemoglobin does not reflect tissue oxygenation or anaemia tolerance in non-bleeding critically il...
08/02/2026

https://zurl.co/rntIl Haemoglobin does not reflect tissue oxygenation or anaemia tolerance in non-bleeding critically ill patients. Central venous oxygen saturation and oxygen extraction ratio are bedside measures that show significant changes after transfusion when abnormal. A multimodal approach including comorbidities, clinical signs, ECG changes, biochemical markers and microcirculatory assessment may optimise timing, but routine integration needs more evidence.

https://zurl.co/4721U Vitamin C provided no benefit across sepsis subtypes, and hydrocortisone showed no survival benefi...
07/02/2026

https://zurl.co/4721U Vitamin C provided no benefit across sepsis subtypes, and hydrocortisone showed no survival benefit in severe community-acquired pneumonia. ICU rapid PCR improved antibiotic stewardship at 24 h but lowered day-14 clinical cure, while biomarker guidance modestly reduced antibiotic duration. Seven days of therapy was noninferior to 14 days for bloodstream infection mortality, and octenidine bathing reduced ICU-acquired primary bacteraemia.

https://zurl.co/u5wBS Locally siloed ICU data limit sepsis research and education, and practice varies widely across h...
07/02/2026

https://zurl.co/u5wBS Locally siloed ICU data limit sepsis research and education, and practice varies widely across hospitals. Sepsis affects nearly 49 million people annually and contributes to one in five deaths, with hospital treatment averaging about €16,000 in France and exceeding €27,000 in Greece. Federated analyses stay within hospitals and return anonymised aggregates, and synthetic data support simulation but not full clinical complexity.

https://zurl.co/yJgAT Early biomarker detection in acute kidney injury is limited by attempts to fit markers of function...
06/02/2026

https://zurl.co/yJgAT Early biomarker detection in acute kidney injury is limited by attempts to fit markers of functional change, structural injury or cell-cycle arrest into the traditional acute kidney injury construct. BigpAK and BigpAK-2 reported biomarker-guided prevention after major surgery. An AKIKI-2 ancillary analysis found novel and conventional biomarkers could not predict renal replacement therapy within 72 h of severe acute kidney injury diagnosis.

https://zurl.co/lMFJj Among 463 Canadian RECOVER participants, 45 of 278 males and 20 of 185 females died in ICU. Male I...
06/02/2026

https://zurl.co/lMFJj Among 463 Canadian RECOVER participants, 45 of 278 males and 20 of 185 females died in ICU. Male ICU survivors had higher median FIM scores at 3 months (117 vs 106), 6 months (119 vs 111.5) and 12 months (121 vs 115). Female survivors had higher BDI-II scores, more moderate and severe depression, and more rheumatology and nephrology visits, while males had more cardiology, endocrinology, surgical and rehabilitation visits.

https://zurl.co/t1XGr Comparable neurological patients can die on stroke units or in emergency departments without donat...
05/02/2026

https://zurl.co/t1XGr Comparable neurological patients can die on stroke units or in emergency departments without donation because mechanical ventilation is not used. ICU transfer for controlled DCD can require intubation and additional central and arterial lines, raising proportionality and resource concerns. A collaborative pathway with emergency, neurology, and neurosurgery teams links donation discussions to agreed goals of care, symptom control, and family support.

https://zurl.co/LzEey Peripheral ECMO cannula-site infection was defined by isolation of a pathogen from local samplin...
05/02/2026

https://zurl.co/LzEey Peripheral ECMO cannula-site infection was defined by isolation of a pathogen from local sampling with purulent discharge or local inflammatory signs. When suspected, local sampling and peripheral blood cultures were recommended, with swabs or aspiration of purulent drainage preferred. Chlorhexidine-impregnated or transparent semipermeable polyurethane dressings were kept until day 7 unless soiled, and routine antibiotic prophylaxis was discouraged.

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