21/11/2025
New paper out today!
I often forget I’m not just a pretend scientist, so I’m actually proud that our new study using UK Biobank data looking at women over 40 with PCOS has been published today.
PCOS is often framed as a “reproductive” condition, but the reality is far more complex. Our analysis shows clear differences in metabolic, hormonal and activity profiles — even when comparing women with PCOS to those matched for age and BMI. In short: it’s not “just weight.” There’s something deeper going on physiologically, and it deserves proper attention.
A few highlights:
- Women with PCOS had less favourable markers like HDL, triglycerides, HbA1c and SHBG, even when BMI was matched.
- They spent more time sedentary and did less vigorous-intensity activity — but total activity levels weren’t dramatically different.
- PCOS was associated with higher rates of chronic conditions like type 2 diabetes, hypertension and obesity.
- Across everyone, those who moved more and sat less had markedly better health profiles. (Shocking, I know.)
- Oh, and women with PCOS were more likely to rate their own health as “poor,” which tells its own story.
What this really shows is that:
PCOS is a serious metabolic condition. It’s underdiagnosed, under-researched, and often underplayed. And lifestyle differences alone don’t explain the poorer health outcomes — there’s a biological load here that needs better recognition and support.
Huge thanks to the team, especially Chris Kite as lead author, what an outstanding scientist (which is amazing considering he did his PhD with me)
If you’re into PCOS, women’s health, exercise science, or you just enjoy charts more than is socially acceptable, full citation (open access) below 📖
Kite C, Kyrou I, Randeva HS, Lahart IM, Brown JEP.
Metabolic, androgenic, and physical activity profiles in women aged over 40 years with polycystic o***y syndrome: A comparative analysis using UK Biobank data. Women’s Health. 2025;21:1–15. doi: 10.1177/17455057251385800