04/11/2025
Breast Cancer is one of the most common cancers in the UK, with 1 in 7 women currently being diagnosed ( it also affects a small percentage of men).
Recently, a very large study ( tracking over 2 million women aged 13-49) for two decades has found that it increases the risk of breast cancer by ‼️24%‼️(overall risk - compared to never users).
Both combined pill and progestin only were examined, with women on the mini pill - containing synthetic progesterone called ‘desogestrel’ 21% more likely to develop breast cancer , whilst women on combined - 12% increase in risk.
The study also found the risk increases the longer you use the pill.
The study does not examine mechanisms of how this is possible , but I suspect ( based on my cancer training) is to do with:
- Oestrogen and synthetic progestins (don’t confuse with natural progesterone) stimulate cell proliferation in breast tissue. Other studies have found higher risk when girls under 18 are taking the pill as their breasts are still developing
- Synthetic progestins ( again, not progesterone) can mimic oestrogen at receptor levels. Some studies examining the links between HRT and breast cancer risk are also finding this - it’s the issue with progestins and how they behave
- The pill generally can deplete B vitamins, which are important for methylation and genomic stability
- The pill can affect the liver in multiple ways - and this is an important detox organ
- the pill affects the gut micro biome - altering composition and gut bacteria diversity- and there is a group of gut bacteria called ‘oestrobolome’, which help detox unhealthy oestrogens , plus most of your immune system lives in your gut
Again those are just suspected mechanisms, several of those or others can be at play.
The good news is that even if you have been on the pill for years, there are so many EVIDENCE based prevention strategies you can employ, and this is something I can help with.