European Thyroid Journal

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European Thyroid Journal

The official journal of the European Thyroid Association, publishing basic, translational and clinical thyroidology.

The European Thyroid Journal publishes papers reporting original research in basic, translational and clinical thyroidology. Original contributions cover all aspects of the field, from molecular and cellular biology to immunology and biochemistry, from physiology to pathology, and from pediatric to adult thyroid diseases with a special focus on thyroid cancer. Readers also benefit from reviews by noted experts, which highlight especially active areas of current research. The journal will further publish formal guidelines in the field, produced and endorsed by the European Thyroid Association.

18/11/2025

🧬Discover the emerging roles of DICER1 and DGCR8 in thyroid tumorigenesis and their impact on miRNA biogenesis and histopathologic diversity.

Our latest open-access review by Lia Rodrigues synthesises the latest evidence on:
- Germline and somatic mutations in DICER1 and DGCR8
- Links to thyroid pathology and oncolytic morphology
- Clinical implications for diagnosis, genetic counselling, and patient management
- Future directions for refining surveillance and therapeutic approaches

📖 Read the full article here: doi.org/10.1530/ETJ-25-0188

11/11/2025

📢 Call for Papers: Paediatric Thyroid Carcinoma – Current Approaches & Challenges

Our latest special collection is led by international experts in the fields of paediatrics and endocrinology with a specialised interest in paediatric thyroid cancer:
- Professor Marek Niedziela
- Professor Hanneke van Santen
- Professor Andy Bauer

This collection will feature a series of review articles on current approaches and ongoing challenges in the evaluation and treatment of thyroid carcinoma. Topics will include the new WHO classification of thyroid tumours and the paediatric Bethesda system for reporting thyroid cytopathology, alongside reviews of imaging, surgical, and non-surgical treatment modalities. We will explore the risks and benefits associated with each aspect of care.

📝 If you specialise in paediatric thyroid carcinoma, this is a valuable opportunity to contribute to a dedicated and expert-led collection. We welcome literature reviews on all aspects of paediatric thyroid carcinoma.

📧 Submit your proposal: etj@bioscientifica.com
💻 https://etj.bioscientifica.com/page/paediatric-thyroid-carcinoma%20/current-approaches-and-challenging-issues-in-paediatric-thyroid-carcinoma

05/11/2025

Thyroid cancer is the most common endocrine malignancy and its tumors show striking genotype-phenotype correlations.

A new review by Giulia Calafato et al. provides a comprehensive, up-to-date summary of the somatic genetic and molecular alterations that drive development and progression of thyroid tumors of follicular cell origin.

Understanding the genetic landscape and related molecular mechanisms is essential to refine clinical management and to identify targeted therapies for aggressive and advanced forms of carcinoma.

Read the full review: doi.org/10.1530/ETJ-25-0104

28/10/2025

🌐 Thyrotoxic periodic paralysis (TPP) is a rare but potentially life-threatening complication of thyrotoxicosis. Due to its rarity, it poses considerable challenges when initiating epidemiological studies.

New research by Gloria Hoi-Yee Li introduces a novel algorithm and electronic medical database from Hong Kong to establish the first large-scale registry of TPP. The data reveal a steady rise in thyrotoxicosis incidence, while TPP remains rare, male-dominant, and clinically stable in terms of hospitalization and length of stay.

This registry offers a new lens for understanding the epidemiology of TPP and enables future studies focused on identifying precipitating factors to improve management strategies for this complication.

📖 Read the research: doi.org/10.1530/ETJ-25-0220

21/10/2025

Could a more systematic search for NUTM1 fusions improve the identification of poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer?

A new case report by Renaud Ciappuccini et al. describes two patients over 65 with PDTC harbouring the NSD3::NUTM1 translocation - a fusion typically seen in younger patients and only rarely reported in primary thyroid cancer.

These findings support the inclusion of NUTM1 fusions in RNA sequencing panels for advanced and refractory thyroid cancers, with potential implications for diagnosis and treatment strategies.

🔗 Read the article: doi.org/10.1530/ETJ-25-0100

16/10/2025

Thyroid cancer with laryngotracheal invasion can lead to life‑threatening airway stenosis, often necessitating urgent and invasive procedures such as tracheostomy, stenting or extensive surgery.

New research by Hiroshi Katoh et al. investigates lenvatinib (LEN) as an initial and bridging therapy, showing its potential to rapidly relieve airway obstruction and to serve as a valuable option during the genetic testing period in anaplastic thyroid cancer (ATC).

✨ These findings position LEN as a promising non‑invasive alternative to emergency interventions and an important therapeutic bridge for patients with ATC.

📖 Read the full study: doi.org/10.1530/ETJ-25-0212

15/10/2025

Exciting news! Our publisher, Bioscientifica, is partnering with Silverchair to deliver an enhanced online experience for our readers, authors and the wider scientific community.

This strategic partnership will bring our entire publishing portfolio, including European Thyroid Journal, to the Silverchair Platform - offering an improved user experience, increased discoverability and business intelligence to support our mission and future growth.

🔗 Read more about the partnership: www.silverchair.com/news/silverchair-partners-with-bioscientifica/

30/09/2025

📌 The recommended gold standard treatment for medullary thyroid cancer (MTC) is surgery - specifically, total thyroidectomy and central neck dissection. This approach is commonly adopted regardless of tumour size, number of foci, patient age, or other demographic and clinicopathological parameters.

📌 Our latest research article by Virginia Cappagli et al. analyses 389 MTC cases (311 sporadic and 78 hereditary) to assess the prevalence of multifocality and provide proof of concept that lobectomy can be safely performed in selected cases. Their findings support a more conservative surgical option for carefully selected patients with sporadic MTC.

📖 Read the full article: doi.org/10.1530/ETJ-25-0074

24/09/2025

In patients with low-risk differentiated thyroid cancer (DTC), hemithyroidectomy is often preferred to preserve thyroid function. Yet, in clinical practice, postoperative thyroid function tends to be lower than anticipated, potentially due to ATA guidelines recommending that postoperative TSH levels remain below 2 mIU/L.

Interestingly, the Danish National Thyroid Cancer Guidelines permit TSH levels to rise up to 4 mIU/L before initiating levothyroxine therapy.

📊 A new study by Tina Toft Kristensen et al. sheds light on outcomes for Danish patients managed under these more lenient TSH thresholds. Their findings offer valuable insights into optimizing postoperative TSH targets to improve outcomes for hemithyroidectomized DTC patients.

Read the full study: doi.org/10.1530/ETJ-24-0282

17/09/2025

🔬 Due to the rarity of medullary thyroid carcinoma (MTC), conducting large controlled trials is challenging, as patient numbers are limited.

Trailblazing research by Eline C Jager et al. introduces a patient-derived organoid model for MTC, offering a promising in vitro platform for physiological studies, drug discovery, tracer testing and drug screening.

📖 Check out this groundbreaking research : doi.org/10.1530/ETJ-24-0405

12/09/2025

Thyroid carcinoma in children and adolescents may be associated with predisposing risk factors and may present across a broad spectrum of clinical behaviour. A stratified approach to the diagnostic evaluation, therapeutic and follow-up plan is necessary to optimise outcome and reduce the risk for complications.

This timely collection will explore the new WHO classification and Bethesda system, alongside current approaches and ongoing challenges in the evaluation and treatment of thyroid carcinoma.

📝 Alongside invited reviews, we welcome literature reviews on paediatric thyroid carcinoma.

Interested in contributing? Submit your proposal to etj@bioscientifica.com

🔗Find out more by visiting: https://etj.bioscientifica.com/page/paediatric-thyroid-carcinoma%20/current-approaches-and-challenging-issues-in-paediatric-thyroid-carcinoma

12/08/2025

💊 Levothyroxine monotherapy is the standard treatment choice for hypothyroidism, yet many patients fail to reach therapeutic goals.
New ETA guidelines from an expert task force offer recommendations to optimise LT4 monotherapy.
Read the guidelines: https://doi.org/10.1530/ETJ-25-0123

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