20/04/2026
📰 NEWS: First targeted oral treatment approved by NICE for patients with Grade 2 glioma in the UK
Thanks to the contribution of patients and researchers at The Royal Marsden NHS Foundation Trust, patients in the UK with Grade 2 glioma, a slow-growing but progressive brain tumour, could benefit from a newly approved targeted therapy.
The drug received approval from the National Institute for Health and Care Excellence (NICE) on March 31 and is now available to patients on the NHS in England.
Declan (pictured), 28, a glioma patient at The Royal Marsden, started taking vorasidenib last year and his tumour has remained stable since being on the treatment.
He said: “Last year, while on holiday in Kenya with my girlfriend, I suddenly had a seizure. It was a huge shock as until that moment, I’d felt completely fine. Back in the UK, I had surgery, but they discovered my tumour had likely been there for a number of years. Because of this, my brain had adapted around it and removing more than five per cent of the tumour would affect my ability to speak. The surgery was done while I was awake and I struggled to speak for three or four months afterwards, needing intensive speech therapy.
“Following the surgery, I started taking vorasidenib and my tumour has remained stable since being on the treatment. I try to stay positive. The care I’ve received at The Royal Marsden has been exceptional.”
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Thanks to the contribution of patients and researchers at The Royal Marsden NHS Foundation Trust, patients in the UK with Grade 2 glioma, a slow-growing but progressive brain tumour, could benefit from a newly approved targeted therapy.