21/10/2025
A study investigated how eucalyptus globulus can protect against renal fibrosis, a major contributor to chronic kidney disease (CKD). Researchers used a preclinical model that mimics kidney injury and tested the effects of the Essential Oil. The Essential Oil was administered orally for 14 days and the essential oil was also evaluated in kidney cells in- vitro to confirm mechanisms. In the preclinical model, there was improved kidney function (reduced creatinine, blood urea nitrogen, urinary protein, and kidney injury molecule-1), suppressed fibrosis (inhibited fibroblast activation and extracellular matrix accumulation, and decreased alpha-SMA—a biomarker of fibrosis), and reduced inflammation (lowered TNF-α, IL-1β, MCP-1) as well as oxidative stress (reduced MDA and restored SOD and GSH). Its molecular mechanisms were determined to be through multiple pathways: TGF-β1/Smad3 Pathway and Tryptophan Metabolism / AhR Pathway, with its primary constituent, 1,8-cineole, displaying strong binding potential to target proteins.
Overall, this research suggests that ingesting eucalyptus EO can protect against renal fibrosis by breaking the cycle of oxidative stress, inflammation, and fibrosis, ultimately providing multi-targeted kidney protection.
Research Reference: https://pubmed.ncbi.nlm.nih.gov/40768808/